Correlation between Bereitschaftspotential and reaction time measurements in patients with Parkinson's disease measuring the impaired supplementary motor area function?

Filipović, Saša R.; Covickovic-Sternic, Nadezda; Radovic, Vladan; Dragašević, Nataša; Stojanović-Svetel, Marina; Kostić, Vladimir

doi:10.1016/s0022-510x(96)05344-0

Cited by 16 publications

(9 citation statements)

References 25 publications

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“…Previous research with MRCPs on pre-frontal lobe patients (Singh and Knight, 1990) and PD patients (Dick et al, 1989;Filipovic et al, 1997) demonstrated reduced BP amplitudes, indicating diminished preparatory activity in the SMA. As stated above, this structure determines the earliest amplitude of the MRCP (Toma et al, 2002), an origin confirmed by the present study.…”

Section: Discussionmentioning

confidence: 84%

Abnormal Motor Preparation in Severe Traumatic Brain Injury with Good Recovery

Russo

Incoccia

Formisano

et al. 2005

Journal of Neurotrauma

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Movement-related cortical potentials (MRCPs) were examined in seven patients with severe traumatic brain injury (TBI) and 12 matched control subjects. All patients had clinically established good recovery by the time of testing. Flexion movements of the index finger of the left or right hand were recorded in two (alternating and repetitive) self-paced conditions and in one externally triggered condition. In control subjects, the bereitschaftspotential (BP) component of MRCP was detected approximately 2000 msec prior to movement onset in the self-paced conditions and was larger and earlier in the alternating compared to the repetitive condition. The BP component was absent in the externally triggered condition. In TBI patients, the BP was greatly reduced and no difference between the alternating-repetitive conditions was detected; in contrast, only small differences were present in the controls for the negative slope (NS) and MP components and no difference for the reafferent positivity (RAP) component. A dipole analysis indicated the supplementary motor area and the premotor area as the likely generators of BP and NS components, respectively. Gradientrecalled echo magnetic resonance imaging allowed the detection of a number of small hypointense lesions primarily located in the frontal lobes, as in diffuse axonal injury. This pattern of results indicates a selective deficit in motor preparation and a relatively spared pattern of activation during and following movement in these patients. Imaging data appear generally consistent with the pattern of MRCPs observed in the patient group. Implications of these results for the problem of slowness in TBI patients are discussed.

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Section: Discussionmentioning

confidence: 84%

Abnormal Motor Preparation in Severe Traumatic Brain Injury with Good Recovery

Russo

Incoccia

Formisano

et al. 2005

Journal of Neurotrauma

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“…Goodrich et al (1989) have also shown that performance of an attention-de- inson's disease is due to impairment of the attention-demanding process of volitional preprogramming. Filipovic et al (1997) found that the difference between choice and simple RT was significantly and negatively associated with the amplitude of the early and peak BP components in Parkinson's disease. This confirms that the failure to preprogramme in simple RT is associated with less motor preparation as indexed by lower amplitude of the early BP component.…”

Section: Response Preparation the Results Of Rt Studiesmentioning

confidence: 90%

Willed Action and Its Impairments

Jahanshahi¹

1998

Cognitive Neuropsychology

210

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Actions are goal-directed behaviours that usually involve movem ent. There is evidence that intentional self-generated actions (willed actions) are controlled differently from routine, stereotyped actions that are externally triggered by environmental stimuli. We review evidence from investigations using positron emission tomography (PET), recordings of movement-related cortical potentials (MRCPs) or transcranial magnetic stimulation (TMS), and conclude that willed actions are controlled by a network of frontal cortical (dorsolateral prefrontal cortex, supplementary motor area, anterior cingulate) and subcortical (thalamus and basal ganglia) areas. We also consider evidence suggesting that some of the cognitive and motor deficits of patients with frontal lesions, Parkinson's disease, or schizophrenia as well as apathy and abulia and rarer phenomena such as primary obsessional slowness can be considered as reflecting im pairment of willed actions. We propose that the concept of a willed action system based on the frontostriatal circuits provides a useful framework for integrating the cognitive, motor, and motivational deficits found in these disorders. Problems remaining to be resolved include: identification of the component processes of willed actions; the specific and differential role played by each of the frontal cortical and subcortical areas in the control of willed actions; the specific mechanisms of impairm ent of willed actions in Parkinson's disease, schizophrenia, and frontal damage; and the precise role of the neurotransmitter dopamine in the willed action system.

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“…The Bereitschaftspotential was recorded according to methodology already established in our laboratory 32. The Ag/AgCl electrodes were attached to three scalp locations: vertex, and contralateral and ipsilateral sensory‐motor area (electrode locations Cz, C3, and C4, respectively, according to the 10–20 International System), while linked electrodes on the earlobes were used as a reference.…”

Section: Methodsmentioning

confidence: 99%

“…The mean slopes of the traces for the two segments were calculated, and the amplitudes at the breaking point (referred as NS1 ) as well as the maximal BP amplitude ( N1 ) immediately before the MO were also measured. To compensate for the superimposed EEG activity interference, the N0, NS1, and N1 amplitudes were actually measured as mean amplitudes in the interval ± 50 ms around the defined points 32. The baseline for amplitude measurements was defined as mean amplitude in the interval 1,500–2,000 ms before the MO.…”

Section: Methodsmentioning

confidence: 99%

Bereitschaftspotential in depressed and non‐depressed patients with Parkinson's disease

et al. 2001

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Impaired initiation and slowed execution of movements are two of the principal characteristics of Parkinson's disease (PD). A similar pattern of movement impairments (psychomotor retardation) can be seen frequently in patients with idiopathic depression. In addition, affective disorders have been frequently reported in patients with different basal ganglia disorders. The aim of this study was to determine whether there are some particularities in the cerebral electrical activity during the preparation and execution of voluntary internally paced movements (i.e., Bereitschaftspotential, BP) in depressed PD patients, which can distinguish them from non-depressed PD patients, as well as from healthy controls. The BPs were recorded in 16 patients with idiopathic PD, eight of whom were depressed (PD-D), and eight of whom were not (PD-ND). Additional recordings were taken from a group of eight age- and sex-matched healthy subjects. Depression was classified using the Research Diagnostic Criteria and the two PD groups were matched for age, disease severity, and disease duration. The amplitudes and slopes of the BPs from PD patients were generally smaller than in controls, but there was no specific pattern of BP changes that distinguished depressed from non-depressed PD patients. In addition, there was no particular association between measures of depression severity and BP parameters. The data suggest that presence of depression in PD might not have any additional deteriorating influence on already impaired preparation for self-paced spontaneous movements.

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Correlation between Bereitschaftspotential and reaction time measurements in patients with Parkinson's disease measuring the impaired supplementary motor area function?

Cited by 16 publications

References 25 publications

Abnormal Motor Preparation in Severe Traumatic Brain Injury with Good Recovery

Abnormal Motor Preparation in Severe Traumatic Brain Injury with Good Recovery

Willed Action and Its Impairments

Bereitschaftspotential in depressed and non‐depressed patients with Parkinson's disease

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