Correlation Between Bioelectrical Impedance Analysis and Chest CT-Measured Erector Spinae Muscle Area: A Cross-Sectional Study

Abstract

BackgroundSkeletal muscle mass (SMM) plays an important part in diverse health and disease states. Bioelectrical impedance analysis (BIA) and computed tomography (CT) are available for its assessment. However, muscle mass assessed by BIA may be influenced by multiple factors. The erector spinae muscle area (ESA) on chest CT is recently presumed to be representative of SMM. This study aimed to derive BIA from the ESA and evaluate the magnitude of association (between ESA measured from chest CT) and BIA.MethodsSubjects hospitalized for health checkups between December 2020 and December 2021, having undergone both BIA (50 kHz, 0.8 mA) and chest CT, were included. ESA was quantified at the level of the 12th thoracic vertebra (T12-ESA) by a standardized semi-automated segmentation algorithm. Low SMM was defined using the Asian Working Group for Sarcopenia criteria. The association between T12-ESA and BIA was then evaluated. Stratified analyses by sex and BMI were also performed.ResultsAmong 606 included subjects (59.7 ± 16.6 years, 63.5% male), 110 (18.2%) had low SMM. BMI in low and normal SMM groups was 20.1 and 24.7 kg/m2, respectively. Current smoking, drinking, chronic obstructive pulmonary disease, and chronic renal dysfunction were more frequently seen in the low SMM group than in the normal SMM group. The final regression model included T12-ESA, weight, BMI, and age, and had an adjusted R2 of 0.806 with BIA. In the validation group, the correlation between T12-ESA-derived BIA and BIA remained high (Pearson correlation = 0.899). Stratified analysis disclosed a stronger correlation between T12-ESA and BIA in male subjects than in female subjects (adjusted R2 = 0.790 vs. adjusted R2 = 0.711, p < 0.05), and a better correlation was observed in obese (BMI ≥ 30 kg/m2) compared with underweight (BMI < 18.5 kg/m2) subjects (adjusted R2 = 0.852 vs. adjusted R2 = 0.723, p < 0.05). Additional analysis revealed a significant correlation between T12-ESA and skeletal muscle cross-sectional area at the 3rd lumbar vertebra (L3-CSA) (adjusted R2 = 0.935, p < 0.001).ConclusionsCT-based assessment of ESA at the T12 level is feasible and correlated well with BIA, especially in male subjects and obese subjects.

Unveiling the Knowledge Frontier: A Scientometric Analysis of COPD with Sarcopenia

“…61 A cross-sectional study demonstrated the feasibility of CT scans to assess erector spinae muscle (ESA) size, particularly in male and obese individuals undergoing health checkups, showing a strong correlation with BIA. 62 Additionally, quantitative measurement of thoracic skeletal muscle area on chest CT scans, including CSA of PM, latissimus dorsi (LAT), and erector spinae muscle (ESM), is associated with lung function, radiologic signs of emphysema, and clinical outcomes in COPD, indicating the value of…”

Association between different obesity indices and carotid intima-media thickness in patients with type 2 diabetes assessed by a decision tree model and logistic regression: A cross-sectional study

“…The results showed that VFA and VAI in the young group and CAVI in the middle-aged group were found to be associated with CIMT thickening. Imaging approaches such as CT or MRI are the gold standards for diagnosing visceral obesity, but studies have shown a good correlation between visceral fat area measured by bioelectrical impedance analysis and CT, and is a viable alternative to CT [28,29] . VAI is used to assess visceral adiposity, which is a strong independent risk factor associated with the development of CVD in T2DM patients [30] .…”

Predictors of poor clinical outcomes including in-hospital death and low ability to perform activities of daily living at discharge in hospitalized patients with chronic obstructive pulmonary disease exacerbation

“…[19][20][21]26,42 A recent report showed that the ESM CSA was closely correlated with total body muscle mass. 43 Tanimura et al 26 demonstrated that the ESM CSA was correlated with severe airflow limitations, respiratory symptoms, and emphysema severity, and was a strong risk factor for mortality in patients with stable COPD. Another study showed that, in the acute setting, a smaller ESM CSA on chest CT performed TherapeuTic advances in respiratory disease at admission was significantly associated with poor recovery of the ability to perform ADL in hospitalized patients with pneumonia.…”

“…19–21,26,42 A recent report showed that the ESM CSA was closely correlated with total body muscle mass. 43 Tanimura et al . 26 demonstrated that the ESM CSA was correlated with severe airflow limitations, respiratory symptoms, and emphysema severity, and was a strong risk factor for mortality in patients with stable COPD.…”