Correlation Between Birth Defects and Dietary Nutrition Status in a High Incidence Area of China

Zhang, Baoyuan; Zhang, Ting; Liangming, Lin; Wang, Fang; Xin, Ruo-Lei; Gu, Xue; He, Yao; Yu, Dongmei; Pei-zhen, LI; Zhang, Qingshan; Zhao, Jin; Qin, Yu-Fu; Yang, Xiufeng; Chen, Gong; Liu, Ju-Fen; Song, Xiaomin; Zheng, Xiaoying

doi:10.1016/s0895-3988(08)60005-7

Cited by 40 publications

(35 citation statements)

References 24 publications

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“…Compromised nutrient intakes during the 'critical windows' of preconception and conception can adversely influence pregnancy outcome, increase risk for birth defects, alter the nutrient composition of breast milk, condition infants and children to altered growth trajectories and predispose them to chronic diseases in later life (2)(3)(4)(5)(6) . Carmichael and co-workers showed that adequate periconception intakes of folate, vitamin B 12 , vitamin B 6 and riboflavin were associated with decreased risk of neural tube defects among Californian women (7) .…”

mentioning

confidence: 99%

“…Carmichael and co-workers showed that adequate periconception intakes of folate, vitamin B 12 , vitamin B 6 and riboflavin were associated with decreased risk of neural tube defects among Californian women (7) . Zhang's group showed that Chinese women of childbearing age with inadequate micronutrient status had a higher risk of birth defects (3) , and Yin and colleagues showed that maternal intake of Mg during the third trimester of pregnancy was predictive of bone mineral density at age 16 years (8) . Moreover, in populations where Fe deficiency is prevalent, children born to women receiving micronutrient supplementation score better in tests of intellectual function, e.g.…”

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confidence: 99%

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Nutritional status as assessed by nutrient intakes and biomarkers among women of childbearing age – is the burden of nutrient inadequacies growing in America?

Rai¹,

Bird²,

McBurney³

et al. 2014

Public Health Nutr.

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Objective: Understanding nutrient intakes among women of childbearing age within the USA is important given the accumulating evidence that maternal body weight gain and nutrient intakes prior to pregnancy may influence the health and well-being of the offspring. The objective of the present study was to evaluate nutritional status in women of childbearing age and to ascertain the influence of ethnicity and income on nutrient intakes. Design: Nutritional status was assessed using data on nutrient intakes through foods and supplements from the National Health and Nutrition Examination Survey. Biomarker data from the Centers for Disease Control and Prevention were used to assess nutritional status for selected nutrients. Poverty-income ratio was used to assess family income. Subjects: White (n 1560), African-American (n 889) and Mexican-American (n 761) women aged 19-30 and 31-50 years were included. Setting: A nationally representative sample of non-pregnant women of childbearing age resident in the USA. Results: African-American women had the lowest intakes of fibre, folate, riboflavin, P, K, Ca and Mg. Women (31-50 years) with a poverty-income ratio of ≤1·85 had significantly lower intakes of almost all nutrients analysed. Irrespective of ethnicity and income, a significant percentage of women were not consuming the estimated recommended amounts (Estimated Average Requirement) of several key nutrients: vitamin A (~80 %), vitamin D (~78 %) and fibre (~92 %). Nutrient biomarker data were generally reflective of nutrient intake patterns among the different ethnic groups. Conclusions: Women of childbearing age in the USA are not meeting nutrient intake guidelines, with differences between ethnic groups and socio-economic strata. These factors should be considered when establishing nutrition science advocacy and policy.

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confidence: 99%

mentioning

confidence: 99%

Nutritional status as assessed by nutrient intakes and biomarkers among women of childbearing age – is the burden of nutrient inadequacies growing in America?

Rai¹,

Bird²,

McBurney³

et al. 2014

Public Health Nutr.

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“…Previous studies found that women of childbearing age in this region had a remarkably insufficient intake of some nutrients, especially folic acid (Zhang et al 2008a).…”

Section: Subjectsmentioning

confidence: 90%

“…Periconceptional folic acid supplementation has been reported to prevent 50-70 % of NTDs (Czeizel and Dudas 1992;De Wals et al 2007). We previously demonstrated that nutrient deficiency is an important independent risk factor for birth defects (Zhang et al 2008a), and lower plasma concentrations of folate and vitamin B12 are related to an increased risk of NTDs in high-risk populations (Zhang et al 2009). Many polymorphisms in folate pathway genes have been investigated and shown to be associated with NTD risk (Zhu et al 2003;van der Linden et al 2006;Boyles et al 2006).…”

Section: Introductionmentioning

confidence: 99%

PCMT1 gene polymorphisms, maternal folate metabolism, and neural tube defects: a case–control study in a population with relatively low folate intake

Wang

Guo

et al. 2013

Genes Nutr

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The PCMT1 gene encodes the protein repair enzyme protein-L-isoaspartate (D-aspartate) O-methyltransferase, which is known to protect certain neural cells against Bax-induced apoptosis. Previous studies have produced inconsistent results regarding the effects of PCMT1 (rs4816 and rs4552) polymorphisms on neural tube defects (NTDs). Reduced maternal plasma folate levels and/or elevated homocysteine (Hcy) levels are considered to be risk factors for NTDs. In order to clarify the key factors contributing to the apparent discrepancy and investigate gene-environment interaction, we conducted a case-control study including 121 cases and 146 matched controls to investigate the association between the two PCMT1 polymorphisms in fetuses and the risk of NTDs in the Chinese population of Lvliang, which has low folate intake. Maternal plasma folate and Hcy levels were also measured, and the interaction between fetal PCMT1 gene status and maternal folate metabolites was assessed. Maternal plasma folate concentrations in the NTD group were lower than in controls (10.23 vs. 13.08 nmol/L, adjusted P = 0.059), and Hcy concentrations were significantly higher (14.46 vs. 11.65 lmol/L, adjusted P = 0.026). Fetuses carrying the rs4816 AG ? GG genotype, combined with higher maternal plasma Hcy, had a 6.46-fold (95 % CI 1.15-36.46) increased risk of anencephaly. The results of this study imply that the fetal PCMT1 rs4816 polymorphism may play only a weak role in NTD formation and that gene-environment interactions might be more significant.

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“…Only two studies reported the folate deficiency rate in Chinese regions, spread across the country (Hao et al, 2003;Zhao et al, 2009). Other folate status and intake assessment studies in China focused on specific regions, characterized by a low NTD prevalence rate, such as in Shanghai (Shrubsole et al, 2001), Jiangsu (Li et al, 1996;Ren et al, 2007) and Anqing (Ronnenberg et al, 2000), or a high prevalence of NTDs, for instance in Shanxi (Li et al, 1996;Zhang et al, 2006;Ren et al, 2007;Zhang et al, 2008) and Beijng (Gao et al, 2003). The target group in most of these studies was limited to Chinese women of childbearing age, premarital women or pregnant women, due to their potential risk of having a baby with an NTD caused by folate deficiency.…”

Section: Folate Deficiency In Chinamentioning

confidence: 99%

Market Potential of Folate Biofortified Rice in China

Steur

Gellynck

Blancquaert

et al. 2013

Handbook of Food Fortification and Health

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Correlation Between Birth Defects and Dietary Nutrition Status in a High Incidence Area of China

Cited by 40 publications

References 24 publications

Nutritional status as assessed by nutrient intakes and biomarkers among women of childbearing age – is the burden of nutrient inadequacies growing in America?

Nutritional status as assessed by nutrient intakes and biomarkers among women of childbearing age – is the burden of nutrient inadequacies growing in America?

PCMT1 gene polymorphisms, maternal folate metabolism, and neural tube defects: a case–control study in a population with relatively low folate intake

Market Potential of Folate Biofortified Rice in China

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