Correlation between Bleeding Times and Platelet Counts in Women with Preeclampsia Undergoing Cesarean Section

Ramanathan, Jaya; Sibai, Baha M.; Vu, Tammy; Chauhan, Dinesh

doi:10.1097/00000542-198908000-00003

Cited by 62 publications

(18 citation statements)

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“…However, bleeding time is not significantly prolonged in mild preeclampsia patients but prolonged significantly in patients with severe preeclampsia and eclampsia. The result of the present study is well correlated with the results of Ramanathan J (1989) 13 , Antony et al (1998) 9 and Burrows et al (1987) 14 . The increase observed was may be due to generalized vasoconstriction.…”

Section: Discussionsupporting

confidence: 92%

Comparison of Cogulation Profile in Pre Eclamptic and Eclamptic Patients With Normotensive Pregnant Patients

Chauhan¹,

Rawat²,

Bisht³

et al. 2014

jemds

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AIM: To compare the coagulation parameters in patients with preeclampsia and eclampsia with normotensive pregnant patients in Nainital district of Uttarakhand state. MATERIAL AND METHODS: From January 2012 to June 2013, coagulation indices including platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), bleeding time (BT) and clotting time (CT) were measured in 100 patients with preeclampsia and eclampsia and compared with 100 normotensive pregnant women. The patients with coagulopathies were excluded. RESULT: In preeclampsia and eclampsia, decrease in platelet count (157.18±56.66 lacs/cumm) was highly significant (p<0.001). PT, aPTT and CT were normal but BT (322.46±171.39 sec) was significantly prolonged (p<0.001) in pre eclampsia and eclampsia patients. CONCLUSION: The abnormalities pertaining to coagulation parameters in hypertensive disorders of pregnancy indicate the intravascular coagulation.

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Section: Discussionsupporting

confidence: 92%

Comparison of Cogulation Profile in Pre Eclamptic and Eclamptic Patients With Normotensive Pregnant Patients

Chauhan¹,

Rawat²,

Bisht³

et al. 2014

jemds

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“…For example, a hallmark study by Harker and Slichter found a strong correlation between platelet count and BT, 2 0 a finding corroborated by a study of women with preeclampsia. 21 However, other reports contradict these findings. 3,17 A recent statement by the College of American Pathologists and the American Society of Clinical Pathologists concluded that the BT cannot accurately predict the risk of surgical hemorrhage, and that a normal BT does not exclude the possibility of excessive hemorrhage during an invasive procedure.…”

mentioning

confidence: 97%

Platelet count may predict abnormal bleeding time among pregnant women with hypertension and preeclampsia

McDonagh

Ray

Burrows

et al. 2001

Can J Anesth/J Can Anesth

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Background: Anesthesiologists often require laboratory data to estimate the bleeding risk among hypertensive pregnant women prior to administering regional anesthesia. Many rely on the bleeding time (BT) in making this determination. We examined whether the platelet count can adequately predict BT among a group of hypertensive parturients.Methods: This retrospective subgroup analysis, taken from a cohort of 2051 hypertensive pregnant women, comprises 87 individuals who underwent both a BT and platelet count prior to delivery. We calculated the correlation between the platelet count and BT at three platelet cut-off points with respect to prolonged BT of eight minutes or more.Results: There was a significant negative correlation between platelet count at delivery and BT [r= -0.45, 95% confidence interval (CI) -0.26 to -0.60; P <0.0001]. All three platelet cut-off points had a sensitivity of less than 66% with negative predictive values below 75% for an abnormal BT. A platelet count #75 x 10 9 /L was specific for the presence of an abnormal BT (specificity 97.8%, 95% CI 91.7-100.0), with a positive predictive value of 95.5% (95% CI 83.1-100.0) and a positive likelihood ratio of 24 (95% CI 3.3-168).Conclusions: In a group of hypertensive parturients, the platelet count appears to be very specific for predicting a prolonged BT. The

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“…Although platelet dysfunction was not diagnosed in the present case, it has been reported previously. 5,6,19 HELLP syndrome which was diagnosed in our patient is known to develop in 10% of pregnancies complicated with severe preeclampsia. In a study of 33 patients with HELLP syndrome 20 epidural anesthesia was performed in eight parturients with no apparent complications.…”

Section: Figure Brain Magnetic Resonance Imaging Showing Bilateral Tementioning

confidence: 58%

Intracranial subdural hematoma following dural puncture in a parturient with HELLP syndrome

Ezri

Abouleish²,

Lee³

et al. 2002

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : To present a case of postpartum bilateral intracranial subdural hematoma after dural puncture during attempted epidural analgesia for labour.C Cl li in ni ic ca al l f fe ea at tu ur re es s: : This complication occurred following accidental dural puncture in a parturient with thrombocytopenia (99,000·µL -1 ) who subsequently developed the syndrome of hemolysis, elevated liver enzymes and low platelets. On the first postoperative day, postdural puncture headache (PDPH) developed. An epidural blood patch (EBP) was deferred to the third postoperative day because of a platelet count of 21,000·µL -1 . However, the headache intensified from a typical PDPH to one which was not posturally related. A second EBP was abandoned after the injection of 5 mL of blood because of increasing headache during the procedure. Magnetic resonance imaging revealed bilateral temporal subdural hematomas. The patient was managed conservatively and discharged home without any sequelae.

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Correlation between Bleeding Times and Platelet Counts in Women with Preeclampsia Undergoing Cesarean Section

Cited by 62 publications

References 0 publications

Comparison of Cogulation Profile in Pre Eclamptic and Eclamptic Patients With Normotensive Pregnant Patients

Comparison of Cogulation Profile in Pre Eclamptic and Eclamptic Patients With Normotensive Pregnant Patients

Platelet count may predict abnormal bleeding time among pregnant women with hypertension and preeclampsia

Intracranial subdural hematoma following dural puncture in a parturient with HELLP syndrome

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