Correlation between blood group type and Catheter-associated urinary tract infections (CA-UTI) in critically ill patients: A Retrospective Cohort Study

Abstract

Background: CA-UTI consider one of the most common hospital acquired infections. Several risk factors for CA-UTI have been identified. There is no enough evidence regard the impact of ABO type and the risk of CA-UTI acquisition. The aim of this study is to investigate the correlation between ABO types and the risk of having recurrent, reinfection CA-UTI, and MDR reinfection in critically ill.Methodology: A retrospective cohort study of adult ICU patients through 2018 in ICU at tertiary hospital who have confirmed CA-UTI to investigate the correlation between ABO type with the susceptibility of recurrent, reinfection and MDR reinfection CA-UTI in critically ill. 1730 patients were reviewed to screen patients for inclusion into the study,203 patients have confirmed CA-UTI using 2010 IDSA guideline definition.81patients meeting inclusion/exclusion criteria were enrolled. Patients were divided into two groups based on ABO type (O-group Vs. Non-O group). We considered a P value of < 0.05 as statistically significant.Results: Among 81 patients, 37 patients (45.6%) had O blood group type. Patients with O blood group type were associated with lower rate of recurrent CA-UTI (OR 0.28, 95% CI 0.085-0.952, P = 0.0414), multidrug resistant (MDR) organisms (OR 0.05, 95% CI 0.003-0.752, P = 0.0304), shorter ICU LOS (Est (SE): -0.024 (0.045), P = <0.001) and mechanical ventilation duration (Est. (SE): -0.41 (0.066), P = <0.001) compared with non-O blood group type. On the other hand, neither CA-UTI reinfection (OR 1.47, 95% CI 0.357-6.054, P = 0.5538) nor ICU mortality (OR 0.70, 95% CI 0.219-2.257, P = 0.5538) were statistically significant.Conclusion: Patients with non-O group type were statistically significant associated with higher rate of recurrent CA-UTI and MDRO. These data confirm the need for randomized controlled trials with a larger sample size to clarify and confirm our study findings.