Correlation between bone quality and microvascular damage in systemic sclerosis patients

Ruaro, Barbara; Casabella, Andrea; Paolino, Sabrina; Pizzorni, Carmen; Alessandri, Elisa; Seriolo, C.; Botticella, G.; Molfetta, Luigi; Odetti, Patrizio; Smith, Vanessa; Cutolo, Maurizio

doi:10.1093/rheumatology/key130

Cited by 51 publications

(59 citation statements)

References 40 publications

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“…After obtaining written informed consent, a complete blood chemistry evaluation of bone metabolism was made (alkaline phosphatase, parathormone, 25 OH vitamin D, calcium, and phosphorus) ( 6 , 7 ) for all subjects enrolled.…”

Section: Methodsmentioning

confidence: 99%

“…The lumbar spine TBS, a texture analysis parameter correlated to the bone micro-architecture parameters (9,12), was derived for each spine DXA examination by the TBS index (TBS iNsight Medimaps). The lumbar spine L1-L4 TBS was calculated on each spine DXA examination with the operator blinded to clinical parameters and outcomes (6,7,12).…”

Section: Trabecular Bone Scorementioning

confidence: 99%

“…Recent studies demonstrate a higher incidence of osteoporosis (OP) and fractures in SLE patients than in healthy subjects (HS) (3)(4)(5). There is a multifactorial etiology of bone loss in SLE, which includes systemic inflammation; serological, metabolic, and hormonal factors; and maybe also genetic factors and medication (5)(6)(7)(8). Moreover, a high prevalence of morphometric vertebral fractures was observed in SLE patients, although 1/3 had normal bone density, in line with the multifactorial etiology of fractures in SLE (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…It has recently been reported that the trabecular bone score (TBS), an index extracted by DXA that provides an indirect measurement of bone axial microarchitecture, provides vital information on bone quality in several rheumatic diseases (6,7,12).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies demonstrate that patients with rheumatic inflammatory diseases have low vitamin D and an increased risk of low bone mass ( 3 , 6 – 8 ). Currently, the clinical practice gold standard for OP diagnosis, including secondary causes, is a bone mineral density (BMD) analysis by dual-energy X- ray absorptiometry (DXA) ( 9 – 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Trabecular Bone Score and Bone Quality in Systemic Lupus Erythematosus Patients

et al. 2020

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Background: Systemic lupus erythematosus (SLE) patients run a higher risk of having low bone mass due to multifactorial events that include physical inactivity, persistent inflammation, low vitamin D levels, and glucocorticoid treatment. This study aimed at obtaining a comparison between bone involvement in SLE patients and healthy matched subjects (HS). Methods: A total of 40 SLE females (average age 54.1 ± 16.3 years) and 40 age-gender matched HS (average age 54.2 ± 15.9 years) were enrolled after having obtained informed written consent. Bone mineral density (BMD, g/cm 2) of the lumbar spine (L1-L4) was analyzed by a dual-energy X-ray absorptiometry (DXA) scan (GE, Lunar Prodigy). The lumbar spine trabecular bone score (TBS) was derived for each spine DXA examination by the TBS index (TBS iNsight Medimaps). Results: The lumbar spine TBS score was statistically significantly lower in SLE patients than in HS (0.797 ± 0.825 vs. 1.398 ± 0.207, p < 0.001, as was BMD (p < 0.001) in all areas examined. Conclusions: SLE is associated with significant low bone mass as evidenced by DXA and TBS. This study emphasizes the importance of using DXA and TBS in the evaluation of the different aspects of bone architecture.

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Section: Methodsmentioning

confidence: 99%