Correlation between brain damage, associated biomarkers, and medication in psychiatric inpatients: A cross-sectional study

Yoshida, Madoka; Kanzaki, Tetsuto; Mizoi, Mutsumi; Nakamura, Masanao; Uemura, Takeshi; Mimori, Seisuke; Uju, Yoriyasu; Sekine, Keisuke; Ishii, Yukihiro; Yoshimi, T; Yasui, Reiko; Yasukawa, Asuka; Sato, M.; Okamoto, Seiko; Hisaoka, Tetsuya; Miura, Masafumi; Kusanishi, Shun; Murakami, Kanako; Nakano, Chieko; Mizuta, Yasuhiko; Mishima, Shunichi; Hayakawa, Tatsuro; Tsukada, Kazumi; Kashiwagi, Keiko; Igarashi, Kazuei

doi:10.1016/j.cca.2016.11.002

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…The present systematic review reported that most studies here retrieved demonstrated that elevated serum CRP levels are correlated with schizophrenia and are associated with a more severe schizophrenic symptomatology [ 40 , 55 , 62 - 63 , 66 - 69 , 71 - 72 , 77 - 79 , 81 , 84 , 86 - 88 , 95 , 97 , 134 ]; whilst other studies did not confirm these findings [ 57 , 70 - 71 , 74 , 76 , 77 , 80 , 83 , 85 , 91 - 92 ]. Specifically, hsCRP levels are increased in stabilized schizophrenic patients and during the remission and chronic phase of illness [ 63 , 71 , 81 ], are increased in acutely agitated schizophrenics and decreased after acute agitation is controlled by administration of antipsychotics [ 81 ].…”

Section: Discussionmentioning

confidence: 87%

“…A cross-sectional study evaluating the correlation between brain damage, associated biomarkers and medication, recruited 96 inpatients (70 schizophrenic and 26 affected with mood disorders) in Japan [ 88 ]. CRP levels were higher in plasma of both schizophrenic (0.07 mg/dl) and mood disorder (0.14 mg/dl) patients, compared to healthy controls (0.03 mg/dl) [ 88 ].…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the sample, a dis-homogeneous sample has been reported of schizophrenic patients recruited in terms of different socio-demographic characteristics of sample ( i.e ., sex, gender, race, etc . ); some studies specifically recruited some ethnic groups, such as Arabics [ 63 ], Armenians [ 65 ], Egyptians [ 55 , 84 ], Taiwanese [ 67 ], Indians [ 76 ], Japanese [ 78 , 88 ], Chinese [ 81 ], Brazilian [ 82 ], Estonian [ 85 ], Danish [ 86 ], Finnish [ 87 ], which may influence the findings here retrieved. Therefore, the above-mentioned limitations greatly limit the generalizability of findings here reported and have limited the possibility to carry out a clinically significant meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

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Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review

Orsolini

Sarchione

Vellante

et al. 2018

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BackgroundSchizophrenia is a complex illness in which genetic, environmental, and epigenetic components have been implicated. However, recently, psychiatric disorders appear to be related to a chronic inflammatory state, at the level of specific cerebral areas which have been found as well impaired and responsible for schizophrenia symptomatology. Hence, a role of inflammatory mediators and cytokines has been as well defined. Accordingly, the role of an acute inflammatory phase protein, the C-reactive protein (CRP) has been recently investigated.ObjectiveThe objective of the present study is to evaluate how PCR may represent a biomarker in schizophrenia, i.e. correlated with illness phases and/or clinical manifestation and/or psychopathological severity.MethodsA systematic review was here carried out by searching the following keywords ((C-reactive protein AND ((schizophrenia) OR (psychotic disorder))) for the topics ‘PCR’ and ‘Schizophrenia’, by using MESH terms.ResultsAn immune dysfunction and inflammation have been described amongst schizophrenic patients. Findings reported elevated CRP levels in schizophrenia, mainly correlated with the severity of illness and during the recrudescent phase. CRP levels are higher when catatonic features, negative symptomatology and aggressiveness are associated. CRP levels appeared not to be related to suicidal behaviour and ideation.ConclusionCRP and its blood levels have been reported higher amongst schizophrenic patients, by suggesting a role of inflammation in the pathogenesis of schizophrenia. Further studies are needed to better understand if CRP may be considered a biomarker in schizophrenia.

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Section: Discussionmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review

Orsolini

Sarchione

Vellante

et al. 2018

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“…Plasma acrolein levels were higher in patients with rheumatoid arthritis than in healthy individuals [38]. At the same time, in patients with brain damage, increases in plasma acrolein concentrations were associated with increases in interleukin-6 and C-reactive protein [37], suggesting a close relationship between inflammation, SMO activation, and acrolein production.…”

Section: Age-and Disease-related Changes In the Ratio Of Spermine To ...mentioning

confidence: 85%

“…An increase in plasma acrolein concentration and SMO activity has been observed in patients with chronic renal failure, such as diabetic nephropathy, chronic glomerulonephritis, and nephrosclerosis [35]. In patients with cerebrovascular disease, SMO was activated [17,32] and plasma acrolein levels were elevated [36,37]. Plasma acrolein levels were higher in patients with rheumatoid arthritis than in healthy individuals [38].…”

Section: Age-and Disease-related Changes In the Ratio Of Spermine To ...mentioning

confidence: 99%

Changes in Whole Blood Polyamine Levels and Their Background in Age-Related Diseases and Healthy Longevity

Soda

2023

Biomedicines

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The relationship between polyamines and healthy longevity has received much attention in recent years. However, conducting research without understanding the properties of polyamines can lead to unexpected pitfalls. The most fundamental consideration in conducting polyamine studies is that bovine serum used for cell culture contains bovine serum amine oxidase. Bovine serum amine oxidase, which is not inactivated by heat treatment, breaks down spermine and spermidine to produce the highly toxic aldehyde acrolein, which causes cell damage and activates autophagy. However, no such enzyme activity has been found in humans. Polyamine catabolism does not produce toxic aldehydes under normal conditions, but inflammation and some pathogens provoke an inducible enzyme, spermine oxidase, which only breaks down spermine to produce acrolein, resulting in cytotoxicity and the activation of autophagy. Therefore, spermine oxidase activation reduces spermine concentration and the ratio of spermine to spermidine, a feature recently reported in patients with age-related diseases. Spermine, which is increased by a long-term, continuous high polyamine diet, suppresses aberrant gene methylation and the pro-inflammatory status that progress with age and are strongly associated with the development of several age-related diseases and senescence. Changes in spermine concentration and the spermine/spermidine ratio should be considered as indicators of human health status.

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Measurement of acrolein concentrations in postmortem specimens as an indicator for stroke diagnosis

Matsumoto,

Takasu,

Kanto

et al. 2024

Int J Legal Med

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Correlation between brain damage, associated biomarkers, and medication in psychiatric inpatients: A cross-sectional study

Cited by 5 publications

References 28 publications

Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review

Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review

Changes in Whole Blood Polyamine Levels and Their Background in Age-Related Diseases and Healthy Longevity

Measurement of acrolein concentrations in postmortem specimens as an indicator for stroke diagnosis

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