Correlation between brain tissue oxygen tension and regional cerebral oximetry in uninjured human brain under conditions of changing ventilation strategy

Picton, Paul; Vlisides, Phillip E.; Teig, Magnus; Heth, Jason; Orringer, Daniel; Brooks, Joseph; McKinney, Amy; Mentz, Graciela; Mashour, George A.

doi:10.1007/s10877-022-00821-5

Cited by 1 publication

(2 citation statements)

References 20 publications

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“…Although a high correlation was found between rSO2 and TCD-based CBFv upon acetazolamide infusion (r = 0.77) [41], a lower correlation with CBFv (r = 0.23) was seen during hypercapnia, which was even lower (r = 0.18) when a head-cuff was inflated to restrict perfusion to the scalp of the forehead [42]. rSO2 showed a good correlation with an invasive measurement of brain tissue oxygen (PbrO2) (r = 0.5) during hypercapnia induced by changes in ventilatory settings [43]. Upon clamping of the ICA, the correlation of changes in rSO2 with TCD-based CBFv was higher than for LDF-based scalp flow measurements (r = 0.56 for TCD and 0.13 for LDF) [44].…”

Section: Comparison Of Oxygen Saturation Indices and Reference Techni...mentioning

confidence: 97%

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The Influence of Extracerebral Tissue on Continuous Wave Near-Infrared Spectroscopy in Adults: A Systematic Review of In Vivo Studies

Eleveld

Esquivel-Franco

Drost

et al. 2023

JCM

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Near-infrared spectroscopy (NIRS) is a non-invasive technique for measuring regional tissue haemoglobin (Hb) concentrations and oxygen saturation (rSO2). It may be used to monitor cerebral perfusion and oxygenation in patients at risk of cerebral ischemia or hypoxia, for example, during cardiothoracic or carotid surgery. However, extracerebral tissue (mainly scalp and skull tissue) influences NIRS measurements, and the extent of this influence is not clear. Thus, before more widespread use of NIRS as an intraoperative monitoring modality is warranted, this issue needs to be better understood. We therefore conducted a systematic review of published in vivo studies of the influence of extracerebral tissue on NIRS measurements in the adult population. Studies that used reference techniques for the perfusion of the intra- and extracerebral tissues or that selectively altered the intra- or extracerebral perfusion were included. Thirty-four articles met the inclusion criteria and were of sufficient quality. In 14 articles, Hb concentrations were compared directly with measurements from reference techniques, using correlation coefficients. When the intracerebral perfusion was altered, the correlations between Hb concentrations and intracerebral reference technique measurements ranged between |r| = 0.45–0.88. When the extracerebral perfusion was altered, correlations between Hb concentrations and extracerebral reference technique measurements ranged between |r| = 0.22–0.93. In studies without selective perfusion modification, correlations of Hb with intra- and extracerebral reference technique measurements were generally lower (|r| < 0.52). Five articles studied rSO2. There were varying correlations of rSO2 with both intra- and extracerebral reference technique measurements (intracerebral: |r| = 0.18–0.77, extracerebral: |r| = 0.13–0.81). Regarding study quality, details on the domains, participant selection and flow and timing were often unclear. We conclude that extracerebral tissue indeed influences NIRS measurements, although the evidence (i.e., correlation) for this influence varies considerably across the assessed studies. These results are strongly affected by the study protocols and analysis techniques used. Studies employing multiple protocols and reference techniques for both intra- and extracerebral tissues are therefore needed. To quantitatively compare NIRS with intra- and extracerebral reference techniques, we recommend applying a complete regression analysis. The current uncertainty regarding the influence of extracerebral tissue remains a hurdle in the clinical implementation of NIRS for intraoperative monitoring. The protocol was pre-registered in PROSPERO (CRD42020199053).

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Section: Comparison Of Oxygen Saturation Indices and Reference Techni...mentioning

confidence: 97%

“…Five articles with six sub-studies compared within-subject changes in rSO 2 with changes in reference technique measurements [23,[41][42][43][44]. Correlation coefficients are shown in Figure 4.…”

Section: Comparison Of Oxygen Saturation Indices and Reference Techni...mentioning

confidence: 99%

The Influence of Extracerebral Tissue on Continuous Wave Near-Infrared Spectroscopy in Adults: A Systematic Review of In Vivo Studies

Eleveld

Esquivel-Franco

Drost

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

Correlation between brain tissue oxygen tension and regional cerebral oximetry in uninjured human brain under conditions of changing ventilation strategy

Cited by 1 publication

References 20 publications

The Influence of Extracerebral Tissue on Continuous Wave Near-Infrared Spectroscopy in Adults: A Systematic Review of In Vivo Studies

The Influence of Extracerebral Tissue on Continuous Wave Near-Infrared Spectroscopy in Adults: A Systematic Review of In Vivo Studies

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