Correlation between capillary blood flow of retina estimated by SLDF and circulatory parameters of retrobulbar blood vessels estimated by CDI in diabetic patients

Abstract

This study suggests a positive correlation between the recordings of SLDF of the retinal tissue and the retrobulbar circulatory parameters of the CDI in diabetic patients without diabetic retinopathy.

Relationship between Initial Lens Transparency and Ocular Circulation in Adolescents with Type-1 Diabetes Mellitus, Unstable Glycaemia and Lipid Parameters

“…In those patients, CDI revealed a statistically significantly decreased systolic velocity in the retino-choroidal circulation with a tendency for more pronounced differences in the aforementioned parameters in the lens opacity group. Similar results have been documented by other authors [ 10 – 13 , 26 ].…”

“…Vascular pathology in diabetes develops as a result of impaired autoregulatory mechanisms of small arterioles and venules. The consequences include altered vessel diameter, reduced perfusion pressure and dysregulation of vascular resistance in the retino-choroidal circulation [ 10 – 13 , 22 , 23 ]. Microvascular complications, such as vasculopathy, have been shown to be linked to an increased risk of diabetes [ 24 ].…”

“…Considerable in vitro and in vivo evidence indicates a close correlation between a high resistance index and a low systolic velocity [ 3 , 8 , 10 – 13 , 19 ]. The presence of abnormal response in the CRA and PCA in the diabetic patients with and without lens opacity, suggests that even subtle changes in vascular resistance might occur primarily to lens cloudiness, confirming their limited vascular reactivity to metabolic fluctuation, which could presumably accentuate the diminished autoregulatory capacity of retrobulbar vessels.…”

“…For retrobulbar CDI, the patients were examined in supine position with the probe placed on a closed eyelid after a 5-min delay to avoid fluctuation of arterial blood pressure [ 16 ]. Blood flow parameters such as: peak systolic velocity (PSV, cm/s), end-diastolic velocity (EDV, cm/s), mean velocity (MV, cm/s), pulsatility (PI) and resistance (RI) indices in the ophthalmic artery (OA), central retinal artery (CRA), and temporal posterior ciliary artery (TPCA) were performed by one and the same operator with great experience in a commonly applied CDI technique (Voluson apparatus, 10.5 MHz sector probe) [ 10 – 12 ]. Angle correction was applied to pulsed Doppler recordings to minimize errors in the measured velocities.…”

Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases

“…These findings indicate that CDI might represent an attractive tool for detecting and tracking therapeutic effects on retrobulbar blood flow during the treatment of retinal diseases. Combination of CDI with scanning laser Doppler flowmetry (SLDF) of the retina has revealed a positive correlation between the retinal measurement by SLDF and retrobulbar vessels by CDI in diabetic patients without diabetic retinopathy [87].…”