Correlation between Catecholamine Levels and Outcome in Patients with Severe Head Trauma

Abstract

Some studies have shown that catecholamines and the changes in their levels during and after head trauma can be useful in predicting the outcome in head trauma patients. The goal of this study is to search for a probable relation between urine levels of catecholamines and prognosis in patients with severe head trauma. Fifty four patients with severe head trauma Glasgow Coma Scale (GCS < or = 8) on admission time were recruited in Imam Reza Hospital within one. These patients were included when having no major accompanying trauma in other organs. Twenty four hour urine was collected after admission and levels of metanephrine and nor-metanephrine were measured. The relation between urine levels of these metabolites with final outcome and also with GCS at admission, 24, 48 h and 1 week after admission and discharge time and Glasgow Outcome Scale (GOS) were studied. Fifty two patients, 48 males and 4 females with a mean age of 32.3 +/- 14.7 (3-72) years were included. The main underlying etiologies were motorcycle (46.2%) and car accidents (25%). Diffuse axonal injury, brain contusion and subdural hematoma were three main diagnoses (28.8, 17.3 and 15.4% of the cases, respectively). 19 (36.5%) of the patients expired within the study period. The mean level of metanephrine and normetanephrine in urine were 207.9 +/- 200.5 and 330.2 +/- 218.4 microg in 24 h, respectively. There was no meaningful relation between urine levels of these metabolites and any of GCS and GOS. There was also no meaningful relation between these parameters and final prognosis in patients.

Effects of Slaughter Knife Sharpness on Blood Biochemical and Electroencephalogram Changes in Cattle

“…The stimulating effect of pain and various other stress factors on the sympathetic nervous system resulted in persistently high plasma noradrenaline levels in critically injured patients. Pain is considered a powerful provoker of the sympathoadrenal axis, which increases sympathetic tone and catecholamine release [58]. In this study, significantly higher noradrenaline levels were observed in cattle slaughtered using a commercial sharp knife, which is believed to induce more stress and pain in the animals compared to those slaughtered with a sharp knife.…”

Correlation between Arterial Blood Gas Analysis and Outcome in patients with severe head trauma

“…These findings are in line with similar reports. [8,9] Dumont et al [5] studied 65 patients with traumatic brain injury in a retrospective manner to determine the effect of prehospital hyperventilation on in-hospital mortality. According to their findings, survival was related to admission PCO 2 in patients requiring intubation.…”

Substantiation and fundamentals of medico-psychological escort in the child neurosurgery sphere

“…Однією з важливих і актуальних проблем дитячої нейрохірургії є черепно-мозкова травма дитини першого року життя [6]. Черепно-мозкова травма дитини -це потужна стресова ситуація, яка створює передумови для розвитку порушення психоемоційного стану батьків, що, у свою чергу, негативно впливає як на стан батьків, так і на стан дитини та потребує заходів психотерапевтичної корекції [7,8].…”