“…The pooled model showed a significantly shorter OS with CXCR4 over-expression patients in hematological malignancy (7 studies, 764 patients, HR=1.93, 95% CI, 1.33-2.79, Figure 10) [12-18], breast cancer (18 studies, 4125 patients, HR=1.58, 95% CI, 1.29-1.94, Figure 11) [10, 11, 19-34], colorectal cancer (5 studies, 375 patients, HR=1.83, 95% CI, 1.32-2.53, Figure 12) [36, 37, 39-41], esophageal cancer (7 studies, 886 patients, HR=1.65, 95% CI, 1.24-2.19, Figure 13) [42-48], head and neck cancer (7 studies, 577 patients, HR=2.02, 95% CI, 1.37-2.97, Figure 14) [54-60], renal cancer (5 studies, 594 patients, HR=2.93, 95% CI, 2.06-4.15, Figure 15) [61, 62, 64-66], lung cancer (6 studies, 573 patients, HR=2.51, 95% CI, 1.64-3.83, Figure 16) [8, 67-69, 71, 72], gynecologic cancer (7 studies, 796 patients, HR=2.24, 95% CI, 1.11-4.50, Figure 17) [9, 77-82], liver cancer (2 studies, 256 patients, HR=2.75, 95% CI, 2.02-3.75) [88, 89], prostate cancer (2 studies, 109 patients, HR=2.67, 95% CI, 1.61-4.42) [86, 87] and gallbladder cancer (1 studies, 72 patients, HR=2.30, 95% CI, 1.10-4.80) [92]. Based on the available data, the associations between CXCR4 over-expression and PFS were inconclusive in gastric cancer (5 studies, 755 patients, HR=1.94, 95% CI, 0.86-4.35, Figure 18) [49-53], melanoma (3 studies, 136 patients, HR=1.93, 95% CI, 0.88-4.25, Figure 19) [74-76], pancreatic cancer (2 studies, 320 patients, HR=1.34, 95% CI, 0.63-2.83) [84, 85] and sarcoma (2 studies, 168 patients, HR=5.14, 95% CI, 0.64-41.50) [90, 91].…”