Correlation Between Clinical and Histopathologic Diagnosis of Oral Potentially Malignant Disorder and Oral Squamous Cell Carcinoma

Abstract

Objective: To determine the frequency of oral potentially malignant disorders and Oral Squamous Cell Carcinoma (OSCC) and evaluate the consistency between their clinical and pathological features. Material and Methods: This retrospective study was conducted on records with a diagnosis of oral leukoplakia, oral erythroplakia, erythroleukoplakia, actinic cheilitis, lichen planus, and OSCC in the Pathology Department of Kerman dental school from September 1997 to September 2017. Data were analyzed in SPSS 21 at the significance level of ≤5%. Results: There were 378 cases of oral potentially malignant disorders and 70 cases of OSCC with a mean age of 46.82 ± 15.24 years. Buccal mucosa was the most frequent site, and lichen planus the most common lesion. Females were significantly older than males in leukoplakia and carcinoma in situ lesions. Clinical diagnosis and histopathology were consistent in 69.03% of cases. Conclusion: Clinical and histopathological diagnoses were consistent in 69.03% of records. The highest degree of clinical compliance with histopathology was observed in OSCC. Dentists should pay attention to oral potentially malignant disorders for early diagnosis to prevent their transformation to malignancy.

Clinical and histopathological correlation of oral malignancy and potentially malignant disorders based on a screening program at high-risk population in Tamil Nadu, India

“…Left buccal mucosa was the most common site of OPMD followed by right buccal mucosa and right vestibule in our study, the finding of buccal mucosa to be the most common site of OPMD is in line with studies by Torabi et al (15), and M. Bokor-Bratic et al, (20). Recently the WHO Collaborating Centre for oral cancer comprising the expert group on oral cancer and OPMD revised the classification of OPMDs and considered Oral leukoplakia, oral lichen planus, oral lichenoid lesions, proliferative verrucous leukoplakia, and oral submucous fibrosis as OPMDs (15). These OPMDs have a differing percentage of malignant transformation based on the type of lesion from 5%-18%.…”

A Clinicohistopathological Characterization of Oral Lichen Planus: A Cross-Sectional Study

“…This is not a common finding in the literature, and variations may be attributed to different clinical classifications of OLP, differing levels of interobserver variability, or adherence to stringent patient selection criteria [ 7 ]. The results of the present investigation were congruent with those of Torabi et al, who noted that the buccal mucosa is the most typical site for OLP, which can be ascribed to the epithelial thickness and the degree of keratinization [ 13 ]. According to De Sousa et al, the characteristic histological findings in OLP include lichenification of the basal layer, accompanied by a prominent layered lymphocytic infiltration explicitly beneath the epithelium; the existence of many eosinophilic colloid Civatte bodies along the epithelial-connective tissue interface; the lack of hyperplasic or, more frequently, saw-tooth interpapillary ridges; varying grades of orthokeratosis/parakeratosis; and differing thickness of spinous cellular layer [ 5 ].…”

“…This is not a common finding in the literature, and variations may be attributed to different clinical classifications of OLP, differing levels of interobserver variability, or adherence to stringent patient selection criteria [7]. The results of the present investigation were congruent with those of Torabi et al, who noted that the buccal mucosa is the most typical site for OLP, which can be ascribed to the epithelial thickness and the degree of keratinization [13].…”