Correlation Between Cone-Beam Computed Tomography and High-Resolution Peripheral Computed Tomography for Assessment of Wrist Bone Microstructure

Mys, Karen; Варга, П.; Gueorguiev, Boyko; Hemmatian, Haniyeh; Stockmans, Filip; Lenthe, G. Harry van

doi:10.1002/jbmr.3673

Cited by 18 publications

(16 citation statements)

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“…The bone mass was scanned and analyzed with a micro‐CT system (VivaCT 40; Scanco Medical, Brüttisellen, Switzerland) as previously described in Mys et al . (21). To determine the bone mass indices, including the bone volume:total volume ratio (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), and trabecular separation (Tb.Sp), 0.5–5.5 mm below the lowest point of the growth plate was selected as the region of interest, and cross‐sectional images were scanned at 21 μm resolution.…”

Section: Methodsmentioning

confidence: 99%

Nicotine exposure during pregnancy programs osteopenia in male offspring rats via α4β2‐nAChR–p300‐ACE pathway

Xiao¹,

Wen

Pan

et al. 2019

The FASEB Journal

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Prenatal nicotine exposure (PNE) induces developmental toxicity in offspring. However, the long‐term harmful effects on bone development and the intrauterine programming mechanism attributed to PNE remain unclear. In the present research, pregnant Wistar rats were injected subcutaneously with nicotine (2 mg/kg/d) to obtain and analyze bone samples from the fetal and adult offspring. Bone marrow mesenchymal stem cells (BMSCs) were treated with nicotine during osteogenic differentiation to clarify the related molecular mechanisms. The results indicated that PNE led to bone dysplasia in the fetuses and reduced bone mass in the adult offspring, which was mediated by the sustained activation of the local bone renin angiotensin system (RAS) and suppressed osteogenic differentiation before and after birth. In vitro, nicotine suppressed BMSCs' osteogenic function through promoting angiotensin‐converting enzyme (ACE) expression and activating RAS. Furthermore, nicotine induced histone acetylase p300 into the nuclei of the BMSCs by acting on the α4β2‐nicotinic acetylcholine receptor (α4β2‐nAChR), leading to the increased histone 3 lysine 9 acetylation level of ACE and RAS activation. Taken together, the sustained activation of local bone RAS mediated prenatal nicotine‐induced osteopenia in adult offspring via the α4β2‐nAChR–p300‐ACE pathway.—Xiao, H., Wen, Y., Pan, Z., Shangguan, Y., Magdalou, J., Wang, H., Chen, L. Nicotine exposure during pregnancy programs osteopenia in male offspring rats via α4β2‐nAChR–p300‐ACE pathway. FASEB J. 33, 12972–12982 (2019). http://www.fasebj.org

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Section: Methodsmentioning

confidence: 99%

Nicotine exposure during pregnancy programs osteopenia in male offspring rats via α4β2‐nAChR–p300‐ACE pathway

Xiao¹,

Wen

Pan

et al. 2019

The FASEB Journal

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“…Acquisition times can be much faster (<1 min vs. 6 to 9 min) than HR-pQCT due to the larger detector sizes. Improvements to image reconstruction can advance the accuracy of bone microarchitectural measurement to be comparable with HR-pQCT (95,96). Therefore, cone-beam CT could be a viable modality to complement HR-pQCT imaging, thereby increasing access.…”

Section: Disadvantages Of Hr-pqct Scanning and The Limited Field Of Viewmentioning

confidence: 99%

High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease

et al. 2020

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High resolution peripheral quantitative computed tomography (HR-pQCT) is a 3-dimensional imaging modality with superior sensitivity for bone changes and abnormalities. Recent advances have led to increased use of HR-pQCT in inflammatory arthritis to report quantitative volumetric measures of bone density, microstructure, local anabolic (e.g., osteophytes, enthesiophytes) and catabolic (e.g., erosions) bone changes and joint space width. These features may be useful for monitoring disease progression, response to therapy, and are responsive to differentiating between those with inflammatory arthritis conditions and healthy controls. We reviewed 69 publications utilizing HR-pQCT imaging of the metacarpophalangeal (MCP) and/or wrist joints to investigate arthritis conditions. Erosions are a marker of early inflammatory arthritis progression, and recent work has focused on improvement and application of techniques to sensitively identify erosions, as well as quantifying erosion volume changes longitudinally using manual, semi-automated and automated methods. As a research tool, HR-pQCT may be used to detect treatment effects through changes in erosion volume in as little as 3 months. Studies with 1-year follow-up have demonstrated progression or repair of erosions depending on the treatment strategy applied. HR-pQCT presents several advantages. Combined with advances in image processing and image registration, individual changes can be monitored with high sensitivity and reliability. Thus, a major strength of HR-pQCT is its applicability in instances where subtle changes are anticipated, such as early erosive progression in the presence of subclinical inflammation. HR-pQCT imaging results could ultimately impact decision making to uptake aggressive treatment strategies and prevent progression of joint damage. There are several potential areas where HR-pQCT evaluation of inflammatory arthritis still requires development. As a highly sensitive imaging technique, one of the major challenges has been motion artifacts; Klose-Jensen et al. HR-pQCT for Inflammatory Rheumatic Disease motion compensation algorithms should be implemented for HR-pQCT. New research developments will improve the current disadvantages including, wider availability of scanners, the field of view, as well as the versatility for measuring tissues other than only bone. The challenge remains to disseminate these analysis approaches for broader clinical use and in research.

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“…Even Scanco does this when it describes the XtremeCT II: "For compatibility with the previous generation HR-pQCT, a XtremeCT I equivalent protocol is available." (5) With this letter, we would also like to take the opportunity to correct the following inaccuracies in our manuscripts: the current of the CBCT was 700 to 1300 μA ( Table 1 in our original publication (2) ); the range of values for XtremeCT was 0 to 200,000 and the threshold was given in permille, and no rescaling was applied to the XtremeCT II values ( Table 2 in our original publication (2) ). Finally, the correct formula for RMSE reads:…”

Section: To the Editormentioning

confidence: 99%

“…

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mentioning

confidence: 99%

“…With this letter, we would also like to take the opportunity to correct the following inaccuracies in our manuscripts: the current of the CBCT was 700 to 1300 μA (Table 1 in our original publication); the range of values for XtremeCT was 0 to 200,000 and the threshold was given in permille, and no rescaling was applied to the XtremeCT II values (Table 2 in our original publication). Finally, the correct formula for RMSE reads:

italicRMSE = \sqrt{\frac{1}{N} \sum_{i = 1}^{N} {(V_{microCT, i} - \frac{V_{invivoScanner, i} - b}{a})}^{2}}

…”

mentioning

confidence: 99%

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Reply Letter to the Editor: Clinical in Vivo Assessment of Bone Microarchitecture With CT Scanners: An Enduring Challenge

Mys

Варга

Gueorguiev

et al. 2019

Journal of Bone and Mineral Research

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We thank Drs Tran, Vilayphiou, and Koller for their Letter to the Editor (1) commenting on our recent publication (2) in this journal. In their letter, they highlight the need for in vivo imaging of bone microarchitecture. We cannot agree more. As a matter of fact, this notion was at the basis of our work as there is a strong demand in clinical practice for bone microstructural imaging and subsequent quantitative analyses. We also fully agree with their conclusion that "…both HR-pQCT and CBCT are useful devices for bone microarchitectural research." Indeed, the devices possess different components affecting the field of view (FOV), the effective dose, and the ability to measure fine microarchitectural parameters.In our article, we made a comparative analysis on some of the technical specifications of the HR-pQCT (XtremeCT and Xtreme CT II) scanners, manufactured by Scanco Medical AG (Bruttisellen, Switzerland) and CBCT (NewTom 5G), manufactured by Cefla (Verona, Italy). According to Tran and colleagues, this comparison was at places unclear and "…several figures were simply inaccurate." First, we inform you that Tran and colleagues confirmed to us in separate writing that the latter statement does not relate to any of the figures in our article but to some of the numbers we used when comparing HR-pQCT and CBCT scanners; these issues will be discussed below.Tran and colleagues are right that the CBCT device allows for several acquisition protocols. In our article, we used a cubic 6 x 6 x 6 cm 3 field of view (FOV) when scanning trapezia. This protocol would have allowed us to scan an object of 6 cm in height and would have required 6 to 7 stacks when using the XtremeCT or XtremeCT II; this would have resulted in long scanning times of 20 and 12 minutes for the XtremeCT and XtremeCT II, respectively, as nicely illustrated in Table 1 of Tran and colleagues. (1) We mentioned an effective radiation dose at the wrist of 1.6 μSv when using CBCT. This value had been reported by Koivisto and colleagues in their dose measurements at the wrist. (3) The 14.3 μSv mentioned by Tran and colleagues is taken from another article by Koivisto and colleagues (4) and refers to the effective radiation dose at the ankle. In our draft manuscript, we referred to the 2015 Koivisto article. The 2018 Koivisto article had been suggested to us during the review process as a replacement for the 2015 Koivisto article; we apologize for not having adapted the reference accordingly. The difference in effective dose can be explained by the current modulation that has been built into the scanner to reduce the radiation dose. Note that the current (16 mA) mentioned by Tran and colleagues is an upper limit; in general, the actual current will be lower, though we did not do any dosage measurements to confirm the reported findings. We believe that the optimization of the dosage and the effects on image quality and morphometric analyses are interesting topics for future studies.In their letter, Tran and colleagues mentioned that we reported 60 μSv when u...

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Correlation Between Cone-Beam Computed Tomography and High-Resolution Peripheral Computed Tomography for Assessment of Wrist Bone Microstructure

Cited by 18 publications

References 13 publications

Nicotine exposure during pregnancy programs osteopenia in male offspring rats via α4β2‐nAChR–p300‐ACE pathway

Nicotine exposure during pregnancy programs osteopenia in male offspring rats via α4β2‐nAChR–p300‐ACE pathway

High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease

Reply Letter to the Editor: Clinical in Vivo Assessment of Bone Microarchitecture With CT Scanners: An Enduring Challenge

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