Correlation between cyanide-induced decreases in ocular Ca&lt;sup&gt;2+&lt;/sup&gt;-ATPase and lenticular opacification

Okolie, Ngozi Paulinus; Audu, K

doi:10.4314/jmbr.v3i1.10654

Cited by 8 publications

(9 citation statements)

References 14 publications

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“…Likewise, Shwetha et al, (2012) and Ramzy (2014) reported similar findings on the effect of sub lethal concentration of zinc cyanide and toxic concentration of sodium cyanide on the ATPase activity of Cirrhinus mrigala and the freshwater fish-Nile Tilapia. Okolie and Audu (2004) had earlier observed that cyanide, specifically inhibits the enzyme activity of Ca 2+ -ATPase in lens and vitreous humour in rats resulting in visual impairment via the disruption of ocular calcium homeostasis, a confirmation of the toxic effect of cyanide to the Ca 2+ -ATPase of animals, rat and fish inclusive. Thus, Ca 2+ -ATPase of the test specimens is sensitive to cyanide and will be a useful biomarker for detection and mechanistic studies of the toxicant.…”

Section: Resultsmentioning

confidence: 85%

“…Major sources of cyanide release to streams, lakes and rivers are discharge from gold mining, public owned water treatment plant, iron and steel production plants, organic chemical industry and notably effluent and waste from the processing of cassava and its products. Cyanide is a potent respiratory poison in aerobic organism which combines irreversibly with ferrocytochrome a/a 3 thereby inhibiting electron transport, mitochondrial oxygen uptake and cellular respiration (Jones et al, 1984;Greer and Jo 1995;Okolie and Audu, 2004;Kadiri,2015). Ca 2+ ion is an ions required by ATPase for their activity which involves cleavage of ATP to ADP/AMP and inorganic phosphate with liberation of energy.…”

Section: Introductionmentioning

confidence: 99%

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Respiratory Surveillance and Ca2+-ATPase Enzyme Activity Studies of Clarias gariepinus Exposed to Acute Toxicity of Cyanide

Kadiri

2016

ILNS

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ABSTRACT. Potassium cyanide, a highly contaminating and toxic aquatic ecosystems pollutant was investigated for acute toxicity on the freshwater fish Clarias gariepinus. Its effect on the Ca 2+ -ATPase activities in the liver, gills, muscle and intestinal tissues and oxygen consumption index was studied. Short-term toxicity test was carried out by static renewal bioassay test over a 96 h period using a lethal concentration (LC 50 ) value of 0.361mg/mL. Potassium cyanide was highly toxic to the animal tested. Results reveal that normal respiratory activity (O 2 consumption) of the fish was significantly affected and there was significant decreased in the Ca 2+ -ATPase activities at the end of exposure periods (24, 48, 72 and 96 h). Correlation analysis reveals a strong relationship between oxygen consumption index and ATPase enzyme activity of Clarias gariepinus exposed to the toxicant. This study reflects the toxic effect of potassium cyanide to the freshwater fish, Clarias gariepinus and suggestion on the possible application of Ca 2+ -ATPase activities and oxygen consumption index as possible biomarkers for early detection of cyanide poisoning in aquatic bodies.

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Section: Resultsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Respiratory Surveillance and Ca2+-ATPase Enzyme Activity Studies of Clarias gariepinus Exposed to Acute Toxicity of Cyanide

Kadiri

2016

ILNS

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“…Cyanide is also responsible for the development of early-onset cataract [37]. The effect of cyanide toxicity on Ca 2+ -ATPase activities may result in the disruption of vitreous and lenticular calcium homeostasis, causing Ca 2+ accumulation and lenticular opacification [38].…”

Section: Discussionmentioning

confidence: 99%

Increased risk of tinnitus in patients with early-onset cataracts: a nationwide population-based case-control study

et al. 2020

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Background: This study aimed to investigate the association between early-onset cataract and tinnitus using a population-based database. Methods: Retrospective claims data from the Taiwan National Health Insurance Research Database were analysed. Study subjects comprised patients with early-onset cataract, aged 20-55 years and diagnosed between 2000 and 2010 (n = 2084) and a comparison cohort without the disease (n = 8336). Both cohorts were followed until 2010 to estimate the incidence of tinnitus. To calculate the risk of tinnitus in the case and control groups, Cox proportional hazards models were used and presented as hazard ratios (HRs), adjusted HRs (aHRs) and 95% confidence intervals (CIs). Results: Patients with early-onset cataract had 1.53-fold increased risk (HR = 1.53, 95% CI = 1.17-2.01, p < 0.01) of developing tinnitus than controls. The number of patients with vertigo (p < 0.0001), insomnia (p < 0.0001), anxiety (p < 0.0001) and hearing loss (p < 0.0001) as comorbidities was also significantly higher in the case group. After adjusting for age, sex and all listed comorbidities, patients with increasing age (aHR = 1.04, 95% CI = 1.02-1.07), early-onset cataract (aHR = 1.32, 95% CI = 1.01-1.74), vertigo (aHR = 1.75, 95% CI = 1.15-2.67), insomnia (aHR = 1.48, 95% CI = 1.14-1.93) and hearing loss (aHR = 6.20, 95% CI = 3.58-10.70) had significantly higher risk of tinnitus. Conclusions: Patients with early-onset cataract are at an increased risk of developing tinnitus in subsequent years and should receive further evaluation for early diagnosis and management if any signs of tinnitus occur.

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“…It may be correlated to a study on animal model which demonstrated cataractogenesis as a result of disrupted ocular calcium homeostasis due to cyanide exposure from tobacco. 15 Amongst the modifiable environmental factors tobacco consumption has been proved to be responsible for cataract. 16 Accumulation of sorbitol within the lens changes its hydration and alters its metabolism in diabetic cataract.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and visual outcome in presenile cataract

Verma¹,

Nema²,

Verma³

et al. 2020

IJCEO

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Objective: To study the risk factors and visual outcome in patients of presenile cataract. Materials and Methods: A cross sectional observational study was conducted between January 2016 and January 2017 at a tertiary health care centre. Patients with cataract between age 35 and 55 years were selected. Risk factors like diabetes mellitus, high myopia, dermatological diseases and tobacco consumption were noted. Visual acuity was recorded and a detailed examination of anterior and posterior segments was done. Patients underwent cataract surgery with intraocular lens implantation. Postoperative best-corrected visual acuity was noted. Result: Out of 120 patients there were 47 males (mean age 45.43 ± 6.79 years) and 73 females (mean age 47.33 ± 6.08 years), mostly with bilateral eye involvement (n= 103). Most of the cases were idiopathic (65.9%) whereas association of other risk factors in order of frequency was: tobacco consumption (10.8%), high myopia and diabetes mellitus (7.5% each), prolonged period of outdoor work and long-term steroid use (3.3% each), and dermatological diseases (1.7%). Using Annova test, a significant difference preoperative and postoperative vision was found amongst all age groups (p= 0.032). Conclusion:Tobacco consumption is a strong risk factor for cataractogenesis above diabetes mellitus and high myopia in presenile age group. A significant visual improvement results after cataract surgery and lens implantation.

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Correlation between cyanide-induced decreases in ocular Ca<sup>2+</sup>-ATPase and lenticular opacification

Cited by 8 publications

References 14 publications

Respiratory Surveillance and Ca<sup>2+</sup>-ATPase Enzyme Activity Studies of <i>Clarias gariepinus </i>Exposed to Acute Toxicity of Cyanide

Respiratory Surveillance and Ca<sup>2+</sup>-ATPase Enzyme Activity Studies of <i>Clarias gariepinus </i>Exposed to Acute Toxicity of Cyanide

Increased risk of tinnitus in patients with early-onset cataracts: a nationwide population-based case-control study

Risk factors and visual outcome in presenile cataract

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