Correlation between erythrocyte sedimentation rate and C-reactive protein level in patients with rheumatic diseases

Kotulska, Anna; Kopeć-Mędrek, Magdalena; Grosicka, Anida; Kubicka, Monika; Kucharz, Eugene J.

doi:10.5114/reum.2015.55825

Cited by 16 publications

(12 citation statements)

References 15 publications

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“…In agreement with other previous results (32,47,54), this study showed that serum levels of ESR, RF, and CRP were significantly increased in the AR group. It was noticed that these parameters were significantly lowered by 17-AAG and/or MTX treatments.…”

Section: Discussionsupporting

confidence: 93%

The possible role of heat shock protein-70 induction in collagen-induced arthritis in rats

2019

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Aim This study aimed to evaluate the possible role of heat shock protein-70 (HSP70) induction by 17-allylaminodemethoxygeldanamycin (17-AAG) in collagen-induced arthritis in rats. Material and methods Male Wistar rats were divided into five groups (n = 10/group) and were treated intraperitoneally twice a week for 4 weeks, namely normal control (saline), arthritis control (AR; saline), AR + 17-AAG, AR + methotrexate (MTX), and AR + 17-AAG + MTX. At the end of the treatments, arthritic score was determined and then the animals were sacrificed. Erythrocyte sedimentation rate (ESR), serum levels of HSP70, interleukin-17 (IL-17), tumor necrosis factor-alpha (TNF-α), rheumatic factor (RF), C-reactive protein (CRP), malondialdehyde (MDA), glutathione peroxidase (GPx), and matrix metalloproteinase-9 (MMP-9) were determined. Results In the AR group, all parameters increased significantly, except for GPx, which showed a pronounced decrease. The 17-AAG and/or MTX treatments significantly reduced arthritic score, ESR, IL-17, TNF-α, RF, CRP, MDA, and MMP-9 with significant increase in GPx compared to the AR group. The HSP70 level was significantly higher in the AR + 17-AAG and the AR + 17-AAG + MTX groups but significantly lower in the AR + MTX group as compared to the AR group. Also, it was significantly lower in the AR + MTX group as compared to the AR + 17-AAG group. Conclusion We concluded that HSP70 induction by 17-AAG attenuated the inflammatory process in a rheumatoid arthritis (RA) model induced by collagen, which suggested that HSP70 inducers can be promising agents in the treatment of RA.

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Section: Discussionsupporting

confidence: 93%

The possible role of heat shock protein-70 induction in collagen-induced arthritis in rats

2019

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“…In this study, ESR level was positively correlated with CRP level, which is in line with previous results from some inflammatory diseases such as rheumatic disease [48]. Although many studies have reported that IL-6 level was correlated with ESR or CRP level in various inflammatory conditions, in the present study on CME no correlations of IL-6 with ESR and IL-6 with CRP were identified [49,50].…”

Section: Discussionsupporting

confidence: 92%

Erythrocyte sedimentation rate, C-reactive protein, and interleukin-6 as inflammatory biomarkers in dogs naturally infected with Ehrlichia canis

et al. 2021

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Background and Aim: Canine monocytotropic ehrlichiosis (CME), a tick-borne disease, leads to a systemic inflammatory response syndrome; it is thus important to assess the intensity of inflammation in order to treat it appropriately. The current study was designed to evaluate hematological, biochemical, and inflammatory parameters in dogs naturally infected with Ehrlichia canis compared with those in healthy dogs. We also assessed the relationship among several inflammation-related parameters and considered these parameters for use as inflammatory biomarkers of CME. Materials and Methods: Twenty-eight dogs were divided into two groups based on the results of nested polymerase chain reaction for detecting E. canis, comprising a healthy group (n=11) and an infected group (n=17). A blood sample was collected from each dog to evaluate hematological, biochemical, and inflammatory parameters, with the obtained results being statistically compared between the groups. Moreover, the correlations of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and interleukin-6 (IL-6) were investigated in the 28 dogs. Results: In the infected group, the mean levels of red blood cells, hemoglobin, and hematocrit were significantly lower than in the healthy group, while the mean lymphocyte and monocyte counts were higher. The mean levels of ESR and CRP were significantly higher (p<0.05) in the infected group, whereas no significant differences were found in IL-6 levels between the two groups. In the correlation analysis, ESR and CRP levels were highly correlated (p<0.01, r=0.531). Conclusion: Elevated ESR and CRP levels were found in dogs naturally infected with E. canis, which also presented mild to moderate inflammation in this study. Moreover, CRP was significantly correlated with ESR, so ESR and CRP may serve as inflammatory biomarkers for monitoring CME.

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“…C‐reactive protein is the prototypical acute phase protein and is commonly monitored to track the activity of inflammatory diseases. CRP levels correlate with the erythrocyte sedimentation rate (ESR), and measurement of both parameters has proven useful for monitoring the progression of disease and/or the effectiveness of treatments 4,5 . However, the ESR is influenced by age and sex and shows a relatively slow response to changes in inflammatory conditions 6,7 ; thus, CRP has become the gold standard for assessing inflammation not only in RA patients but also in most of inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Ratio of serum amyloid A to C‐reactive protein is constant in the same patients but differs greatly between patients with inflammatory diseases

Saiki¹,

Uda²

2021

Scand J Immunol

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C‐reactive protein (CRP) is commonly monitored to track the activity of inflammation and has become the gold standard in the management of all inflammatory diseases. Indeed, serum amyloid A (SAA) have seemed to correlate moderately with CRP, but the discrepancy of CRP and SAA levels has often been reported, especially in rheumatoid arthritis. Then, we examined CRP reflects a real magnitude of inflammation in patients with rheumatic and infectious inflammatory diseases. A total of 414 patients with infectious and non‐infectious inflammatory diseases were enrolled. At initial visit, each patient underwent a clinical assessment and had also laboratory tests such as SAA and CRP. In each patient, we carried out a longitudinal analysis of CRP and SAA levels. We determined the inter‐individual correlation between SAA and CRP and also clarified intra‐individual changes of SAA/CRP ratio. SAA and CRP levels changed approximately linearly over time within individuals irrespective of rheumatic and infectious inflammatory diseases. However, SAA/CRP ratios differed dramatically between patients (from 0.117 to 50.8, median 5.71). In patients with high SAA/CRP ratio (>8.44), SAA is a better predictor of inflammation than CRP. In contrast, CRP is a better predictor in patients with low ratio (<3.52). Our results suggest that the SAA/CRP ratio differed greatly between individuals but was constant in intra‐individuals. Low CRP levels could be accompanied by SAA levels predicting any degree of inflammation, implying that CRP is not reflecting a real magnitude of inflammation. To evaluate the real magnitude of inflammation, to access the SAA/CRP ratio in advance is essential.

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Correlation between erythrocyte sedimentation rate and C-reactive protein level in patients with rheumatic diseases

Cited by 16 publications

References 15 publications

The possible role of heat shock protein-70 induction in collagen-induced arthritis in rats

The possible role of heat shock protein-70 induction in collagen-induced arthritis in rats

Erythrocyte sedimentation rate, C-reactive protein, and interleukin-6 as inflammatory biomarkers in dogs naturally infected with Ehrlichia canis

Ratio of serum amyloid A to C‐reactive protein is constant in the same patients but differs greatly between patients with inflammatory diseases

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