Correlation between FOXP3 expression and gastric cancer

Guo, Guoxiao; He, Zhikuan; Shi, Zhongqi

doi:10.3892/ol.2016.4752

Cited by 9 publications

(8 citation statements)

References 33 publications

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“…Interestingly, FOXP3 seems to have the opposite effect on cancer progression in different cancers . Our previous and other studies have found that FOXP3 is closely related to the development of GC, and its specific role and expression of FOXP3 in the progression of GC . The specific and in‐depth study of the exact mechanism of regulation may provide new ideas and theoretical basis for the clinical treatment of GC and the development of new drug targets.…”

Section: Introductionmentioning

confidence: 85%

miR‐133a‐3p/FOXP3 axis regulates cell proliferation and autophagy in gastric cancer

Zhang

Liu

et al. 2020

J of Cellular Biochemistry

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Although many methods and new therapeutic drugs have been developed, the overall survival rate and long-term survival rate of patients with gastric cancer (GC) are still not satisfactory. In this study, we investigated the effects of microRNA miR-133a-3p and transcription factor FOXP3 on proliferation and autophagy of GC cells and their interactions. Our results showed that knockdown of FOXP3 increased the proliferation and autophagy of GC cells.The relationship between FOXP3 and autophagy has not been reported previously. In addition, FOXP3 could directly bind the promoter region of TP53 and inhibit its expression. miR-133a-3p increased the proliferation and autophagy via decreasing the protein level of FOXP3 by targeting its 3′-UTR. Our research provides new insights into the development of GC and provides new ideas and theoretical basis for the clinical treatment of GC and the development of new drug targets. K E Y W O R D S autophagy, FOXP3, gastric cancer, miR-133a-3p, proliferation

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Section: Introductionmentioning

confidence: 85%

miR‐133a‐3p/FOXP3 axis regulates cell proliferation and autophagy in gastric cancer

Zhang

Liu

et al. 2020

J of Cellular Biochemistry

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“…Yoshii et al also showed that FOXP3 expression is associated with lymph node metastasis in signet ring cell carcinoma of the stomach [32]. In addition, the study by Guo on Wistar rats indicated that FOXP3 may be important for gastric cancer development [33]. …”

Section: Introductionmentioning

confidence: 99%

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

Zhang

et al. 2017

Cell Physiol Biochem

3,265

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Background/Aims: There is little published data on the role of FOXP3 in gastric cancer. Methods: FOXP3 expression and localization in gastric cancer tissues and cells were examined by immunohistochemistry, RT-PCR, flow cytometry, western blot, and laser confocal microscopy. CCK8, plate clone, wound healing, and transwell insert assays were performed for gastric cancer cells. Potential molecules and signaling pathways were screened using high-throughput transcriptome sequencing. Results: FOXP3 expression in gastric cancer tissues was higher than that in para-carcinoma tissues. It was restricted to the cytoplasm of para-carcinoma tissues, but was observed in the cytoplasm or/and nuclei of gastric cancer tissues. FOXP3 expression was positively correlated with pathological grading, and was detected in gastric cancer and GES-1 cells, where it was expressed in the cytoplasm alone, or in both the cytoplasm and the nucleus. FOXP3 overexpression promoted cell proliferation, migration, and invasion, while FOXP3 knockdown suppressed these effects. Furthermore, RT-PCR and ELISA confirmed that FOXP3 upregulation resulted in increased TGF-β expression and secretion in gastric cancer cells. Conclusion: FOXP3 expression was associated with degree of gastric cancer differentiation. In addition, upregulated and ectopic tumoral FOXP3 can promote gastric cancer proliferation, migration, and invasion, partly through the TGF-β pathway.

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“…To explore the upstream regulatory molecules of WFDC21P, we used the Promo (alggen.lsi.upc.es) and Jaspar databases (jaspar.genereg.net) to identify its potential transcription factors, and FOXP3 was selected as a possible target considering that its oncogenic functions had been confirmed in a previous GC study [ 27 – 29 ]. According to the TCGA database, FOXP3 is upregulated and associated with poor prognosis in GC (Fig.…”

Section: Resultsmentioning

confidence: 99%

A new candidate oncogenic lncRNA derived from pseudogene WFDC21P promotes tumor progression in gastric cancer

et al. 2021

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As oncogenes and tumor suppressor genes, long non-coding RNAs (lncRNAs) regulate the biological behavior of gastric cancer (GC) cells such as proliferation, invasion, and metastasis through various signal pathways. At present, although numerous lncRNAs that significantly influence the development and progression of GC have been identified, a considerable number of them have not been found and studied yet. In this study, we identified a new lncRNA derived from pseudogenes WFDC21P, which have not been reported in any previous GC study. LncRNA WFDC21P was significantly upregulated in GC cells and tissues, and clinically associated with the pathological stages of advanced GC. WFDC21P promoted proliferation and metastasis of GC cells both in vitro and in vivo. LncRNA WFDC21P was directly bound to GTPase Ran and it promoted the activity of the Akt/GSK3β/β-catenin pathway. Forkhead Box P3 (FOXP3), as a transcription factor of WFDC21P, was directly bound to the promoter region and it positively regulated the transcription of WFDC21P. This finding may provide a novel biomarker and therapeutic target for GC.

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Correlation between FOXP3 expression and gastric cancer

Abstract: Abstract. The aim of the present study was to investigate the expression and function of forkhead box protein 3 (FOXP3) in gastric cancer using a rat model.

Cited by 9 publications

References 33 publications

miR‐133a‐3p/FOXP3 axis regulates cell proliferation and autophagy in gastric cancer

miR‐133a‐3p/FOXP3 axis regulates cell proliferation and autophagy in gastric cancer

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

A new candidate oncogenic lncRNA derived from pseudogene WFDC21P promotes tumor progression in gastric cancer

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