Correlation between gold‐induced enterocolitis and the presence of the HLA‐DRB 1*0404 allele

Evron, Ella; Brautbar, Chaim; Becker, S.J.; Fenakel, G.; Abend, Yitzhak; Sthoeger, Zev; Cohen, P.; Geltner, David

doi:10.1002/art.1780380607

Cited by 14 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DNA typing of HLA-DR alleles from patients with RA confirmed the shared epitope hypothesis, because HLA-DRB1*0401, 0404, 0405, 0408, HLA-DRB1*0101 and DRB1*1402 share the same sequence at positions 70–74 in the third exon, but DRB1*0402 and others do not [7, 14]. HLA antigens have also been reported to be associated with the reactive side effects of drugs to RA [15, 16, 17, 18, 19, 20, 21]and also with the severity of the disease [22, 23, 24, 25, 26, 27, 28, 29, 30]as well as with the susceptibility to RA with extra-articular manifestations [25, 31, 32, 33, 34, 35]. …”

Section: Introductionmentioning

confidence: 57%

Association between HLA-DRB1*15 and Japanese Patients with Rheumatoid Arthritis Complicated by Renal Involvement

Tokunaga¹,

Noda²,

Kaneoka³

et al. 1999

Nephron

View full text Add to dashboard Cite

We performed serological phenotyping of HLA antigens in 175 patients with rheumatoid arthritis (RA) with (n = 41) and without (n = 134) renal involvement (RI), and DNA typing of HLA class II alleles in 75 patients. Among the patients with RA, the frequency of serologically determined HLA-DR4 was found to be significantly increased (odds ratio: 1.8, confidence interval: 1.3–2.5, p = 2.4×10^–4). In the patients without RI, the frequency of serological DR4 significantly increased (odds ratio: 2.2, confidence interval: 1.6–3.3, p = 2.6×10^–5). On the other hand, among the patients with RI, a serological determinant, DR15, did significantly increase (odds ratio: 2.7, confidence interval: 0.9–8.4, p = 1.2×10^–3) in comparison to the controls. At the DNA level, we found that the association of Japanese RA patients with serological HLA-DR4 was based on that with a genotype of HLA-DRB1*0405 (odds ratio: 2.4, confidence interval: 1.5–4.0, p = 4.4×10^–4) and also found an association of HLA-DRB1*1501 (odds ratio: 2.8, confidence interval: 1.2–6.6, p = 0.017) with RA patients having RI. Our results confirmed the association of HLA-DRB1*04 with RA over the ethnic barrier at the DNA level. Our results also suggested a distinct genetic effect of HLA-DRB1*1501 in the aspect of the susceptibility of RI in RA.

show abstract

Section: Introductionmentioning

confidence: 57%

Association between HLA-DRB1*15 and Japanese Patients with Rheumatoid Arthritis Complicated by Renal Involvement

Tokunaga¹,

Noda²,

Kaneoka³

et al. 1999

Nephron

View full text Add to dashboard Cite

show abstract

“…Four Jewish female RA patients who developed goldinduced enterocolitis, were examined for possible genetic predisposition [99]. Results indicated that the DRB1*0404 allele -present in 3 of the 4 patients -may be associated with risk for development of gold-induced enterocolitis.…”

Section: Enterocolitismentioning

confidence: 99%

“…Results indicated that the DRB1*0404 allele -present in 3 of the 4 patients -may be associated with risk for development of gold-induced enterocolitis. Because the prevalence of this allele among the middle and northern European Jewish populations of RA patients without colitis was 9.2 %, authors concluded that HLA DNA typing should be considered in Jews who are contemplating chrysotherapy [99].…”

Section: Enterocolitismentioning

confidence: 99%

Chrysotherapy: a synoptic review

Eisler

2003

Inflamm. res.

109

View full text Add to dashboard Cite

Chrysotherapy - the treatment of rheumatoid arthritis (RA) patients with monovalent gold drugs possessing anti-inflammatory and other properties - has been used with some success for more than 70 years; however, the metabolites generated from gold drugs have not been identified positively and the mechanisms of action are not known with certainty. This account selectively reviews recent available literature on the history of gold in medicine, with emphasis on RA; the role of Au(+) and Au(+) metabolites (Au(CN)(2)(-), Au(+3), Au(o)) and other mechanisms in chrysotherapy; current treatment regimes for RA using gold drugs; chrysotherapy case histories based on 2166 RA patients; and adverse effects of chrysotherapy, mainly various forms of dermatitis. More research seems needed on the role of gold metabolites in the treatment of RA, the use of more sensitive and uniform indicators of treatment success, improved routes of drug administration for maximum efficacy, and the development of gold drugs with minimal side effects.

show abstract

“…Among the more unusual forms of macroscopic colitis are those caused by methotrexate and gold. In gold- induced colitis peripheral eosinophilia is observed in about 25% of the cases [54, 55]. Gold colitis should be suspected in rheumatoid arthritis patients treated with either oral or parenteral gold.…”

Section: Rare Forms Of Colitismentioning

confidence: 99%