Correlation between heparanase gene polymorphism and susceptibility to endometrial cancer

Abstract

Endometrial cancer (EC) is the most common gynecologic malignancy, accounting for 4.8% of all cancers diagnosed in women (Ferlay et al., 2015). There were around 60,000 new cases and 10,000 deaths each year in the United States and its incidence and mortality keeps on rising (Siegel, Miller, & Jemal, 2015, 2018). In China, the incidence of EC has surpassed cervical cancer and ranked first in gynecological cancers in developed cities since 2008 with the widescale

Advanced Biomarkers: Therapeutic and Diagnostic Targets in Urticaria

“…Single-nucleotide polymorphism refers to a DNA sequence polymorphism caused by a single nucleotide variation at the genomic level, which is related to the susceptibility or prognosis of diseases, so SNP can be used as biomarkers of disease such as cancer and skin diseases [114,115]. Studies have found that the polymorphisms of many urticaria-related genes are closely associated with the disease so can be used as markers to predict the severity of disease or the drug treatment effect.…”