Correlation between EGFR mutation status and F¹⁸‐fluorodeoxyglucose positron emission tomography‐computed tomography image features in lung adenocarcinoma

Abstract

Background The purpose of this study was to investigate an association between EGFR mutation status and 18 F‐fluorodeoxyglucose positron emission tomography‐computed tomography ( 18 F‐FDG PET‐CT) image features in lung adenocarcinoma. Methods Retrospective analysis of the data of 139 patients with lung adenocarcinoma confirmed by surgical pathology who underwent preoperative 18 F‐FDG PET‐CT was conducted. Correlations between EGFR mutation status, clinical characteristics, and PET‐CT parameters, including the maximum standardized uptake value (SUVmax), the mean of the SUV (SUVmean), the peak of the SUV (SUVpeak) of the primary tumor, and the ratio of SUVmax between the primary tumor and the mediastinal blood pool (SUVratio), were statistically analyzed. Multivariate logistic regression analysis was performed to identify predictors of EGFR mutation. Receiver operating characteristic curves of statistical quantitative parameters were compared. Results EGFR mutations were detected in 74 (53.2%) of the 139 lung adenocarcinomas and were more frequent in non‐smoking patients. Univariate analysis showed that the SUVmax, SUVmean, SUVpeak, and SUVratio were lower in EGFR ‐mutated than in wild‐type tumors. The receiver operating characteristic curves showed no significant differences between their diagnostic efficiencies. Multivariate logistic regression analysis showed that being a never smoker was an independent predictor of EGFR mutation. Conclusion Quantitative parameters based on 18 F‐FDG PET‐CT have modest power to predict the presence of EGFR mutation in lung adenocarcinoma; however, when compared to smoking history, they are not good or significant predictive factors.

Gene variant profiles and tumor metabolic activity as measured by <i>FOXM1</i> expression and glucose uptake in lung adenocarcinoma

“…This is a complex issue, with numerous factors involved, including tumor stage, co-morbidities, age, performance status, and tumor mutational state. Metabolic activity may not predict the presence of mutations in cancer genes, such as EGFR [18,19]. Consistent with these reports, no significant relationship between EGFR mutation status and SUV was observed in the current study.…”

Value of combining PET/CT and clinicopathological features in predicting EGFR mutation in Lung Adenocarcinoma with Bone Metastasis

“…When combining with other accessible factors, an AUC of predicting EGFR mutations could reach 0.84. Several studies [8,[12][13][14][15][16][17][18][19][20][21][22][23] had evaluated the value of FDG uptake for predicting EGFR status in NSCLC. As described in Table 3, the results were not very consistent.…”

“…Almost all previous studies solely focused on the pSUVmax. Ten of them [8,[14][15][16][18][19][20][21][22][23] revealed that lower pSUVmax was associated with EGFR mutations, and three studies [8,22,23] found lower pSUVmax was an independent predictor for EGFR mutations by multivariate analysis. Meanwhile, two studies [15,19] demonstrated that high pSUVmax was a significant predictor of EGFR mutations, and one [14] didn't show statistical difference in pSUVmax between different EGFR statuses.…”

“…Using FDG tumor uptake as a predictor of EGFR status could be worth exploring. Several studies have investigated the association between SUVmax and EGFR mutations [8,[14][15][16][17][18][19][20][21][22][23][24][25]. However, the results were controversial and conflicting.…”

Enhanced glucose metabolism mediated by CD147 is associated with 18F‐FDG PET/CT imaging in lung adenocarcinoma

“…26,27 Previous studies have shown that 18 F-FDG uptake was associated with genetic alterations in NSCLC, such as KRAS and EGFR mutation. [28][29][30] CD147 as a tumor-associated antigen is highly enriched on the surface of various malignant tumor cells, such as Figure 4 CD147 promoted 18F-FDG uptake in human LUAD cell lines and LUAD xenograft models. (a, b) CD147 promoted 18F-FDG uptake by both stable HCC827 and H1975 cell lines with different CD147 expression levels.…”