Correlation betweenHelicobacter pylori-associated gastric diseases and colorectal neoplasia

Abstract

H. pylori infection as well as H. pylori-associated gastric diseases are risk factors for colorectal neoplasia.

<em>Helicobacter pylori</em> infection is not associated with failure to thrive: a case&ndash;control study

“… 11 , 27 Higher risk of colorectal neoplasia in patients with H. pylori infections is also reported. 28 The unfavorable influences of H. pylori include a short stature and IDA, 29 although these were not evident in our study. However, H. pylori infection does not always have negative consequences, and some effects may be beneficial.…”

Helicobacter pyloriinfection with intestinal metaplasia: An independent risk factor for colorectal adenomas

“…A large population based case-control study that enrolled 156000 individuals showed a positive association between IM and colorectal adenomas (adjusted OR = 1.24, 95%CI: 1.17-1.32), but without including an analysis of the relationship between H. pylori -related IM and colorectal adenomas[ 9 ]. Furthermore, a recent study showed that individuals with IM were more likely to have adenomas with high-grade intraepithelial lesions (OR = 3.218, 95%CI: 0.767-13.509)[ 20 ]. To our knowledge, no study has analyzed the relationship between H. pylori -related IM and colorectal neoplasm.…”

Helicobacter pylori and colorectal cancer—A bacterium going abroad?

“…The majority of case-control studies ( n = 22) were conducted in Asia, an area with a high burden of H . pylori infection [6, 7, 11, 18, 24–26, 28–33, 35, 39–42, 44, 46, 50, 51]. Screening programs for gastric cancer in certain Asian countries include esophagogastroduodenoscopy on a regular basis, which allows assessing H .…”

“…Independent of the method applied, however, the majority of case-control studies ( n = 30) reported a positive association of H . pylori with colorectal adenoma and/or cancer prevalence, with odds ratios varying between 1.15 and 10.6 [6, 7, 9, 11, 12, 16–18, 21–35, 37–40, 42, 46, 51]. A meta-analysis by Wu and colleagues (2013) reported a summary estimate of 1.66 (95% confidence interval: 1.30–1.97) for colorectal adenoma and 1.39 (95% confidence interval: 1.18–1.64) for CRC [52], which reflects reported results from the majority of case-control studies cited in this review.…”

“…As described above, several case-control studies found higher odds for colorectal adenoma and cancer in individuals with H . pylori –related gastric lesion compared with healthy controls [11, 35, 39, 42].…”