Correlation between <scp>TLR</scp>2,<scp>TLR</scp>3,<scp>TLR</scp>4, and <scp>TLR</scp>9 polymorphisms and susceptibility to and prognosis of severe hepatitis among the newborns

Xiao, Qin; Dong, Yubin; Cao, Yaqin; Luo, Ying-Mei

doi:10.1002/jcla.22292

Cited by 9 publications

(8 citation statements)

References 29 publications

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“…In the present study, the SNP rs5743708 was related to protection against disease [26] and susceptibility to rheumatic fever (caused by Gram-positive bacteria) [27], tuberculosis [24], cytomegalovirus [30,50], chronic hepatitis C [51], endocarditis [25] and infection by Staphylococcus [23,45]. No significant associations were found between this SNP and mononucleosis, complicate skin and structured skin infections (cSSSIs), AIDS and neonatal chronic hepatitis [31,38,39,42]. In Staphylococcus infection, the SNP rs5743708 was most commonly found related with a susceptibility role, being the 'A' allele variant predominant in a French population by Lorenz et al 2000, while the wild-type G allele in a study by Żukowski et al, 2017 in a Polish population [23,45].…”

Section: Usa Rs5743708mentioning

confidence: 56%

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The Relationship of TLR2 Polymorphisms with Infectious Diseases

Silva

Lima

et al. 2021

ARRB

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The proinflammatory response induced by Toll-Like receptors (TLR) is considered the host's first defense line. Single nucleotide polymorphisms (SNPs) correspond to the most frequent type of variation in the human genome, and due to the importance of TLR2 in the immune response, SNPs in the TLR gene are related to susceptibility or resistance to various diseases. Thus, the objective of the present study was to identify the polymorphisms existing in the TLR2 gene that may cause susceptibility or protection against infectious diseases. We conducted a systematic review of the literature in the databases Science Direct, National Library of Medicine National Institutes of Health of the USA (PUBMED), Cochrane Collaboration and Medical Literature Analysis and Retrieval System Online (MEDLINE) between 2000 to 2020. The search resulted in 32 articles, all of which in English. Thus, it was demonstrated that the related polymorphisms are extremely important for the identification of related pathologies, whether for the susceptibility or protection of the individual to the diseases, also being essential for the mechanisms of signal generation and immune responses, and finally indicating that a balance between activation and inactivating these receptors to prevent an excessive inflammatory or immune response.

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Section: Usa Rs5743708mentioning

confidence: 56%

“…these SNPs with early, but not late, onset of pre-eclampsia. Correlation between TLR2, TLR3, TLR4, and TLR9 polymorphisms and susceptibility to and prognosis of severe hepatitis among the newborns [42].…”

Section: Pubmedmentioning

confidence: 99%

The Relationship of TLR2 Polymorphisms with Infectious Diseases

Silva

Lima

et al. 2021

ARRB

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“…In the liver tissues, TLRs are extensively expressed in hepatocytes and other cells, and they showed a critical role in liver physiological function ( Schwabe et al, 2006 ; Chen and Sun, 2011 ). The most prominent hepatic TLRs are TLR2 and TLR4 have been shown to be important for the production of the inflammatory response observed in different models of experimental hepatic injury such as hepatic ischemia, inflammation, and acute hepatic failure ( Tu et al, 2012 ; Mahmoud et al, 2014 ; Qiu et al, 2018 ). Importantly, activation of TLRs signaling pathways is reported to be regulated during oxidative stress ( Gustot et al, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

TLRs-JNK/ NF-κB Pathway Underlies the Protective Effect of the Sulfide Salt Against Liver Toxicity

Abdel‐latif

Heeba

Hassanin³

et al. 2022

Front. Pharmacol.

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Hydrogen sulfide (H2S) is an endogenously gas transmitter signaling molecule with known antioxidant, anti-inflammatory, and cytoprotective properties. Although accumulating evidence shows the therapeutic potential of H2S in various hepatic diseases, its role in cyclophosphamide (CP)-induced hepatotoxicity remains elusive. The present study was undertaken to investigate the impact of endogenous and exogenous H2S on toll-like receptors (TLRs)-mediated inflammatory response and apoptosis in CP-induced hepatotoxicity. Either an H2S donor (NaHS (100 μM/kg) or an H2S blocker [dl-propargylglycine (PAG) (30 mg/kg, i. p.)], was administered for 10 days before a single ip injection of CP (200 mg/kg). NaHS attenuated conferred hepatoprotection against CP-induced toxicity, significantly decreasing serum hepatic function tests and improving hepatic histopathology. Additionally, NaHS-treated rats exhibited antioxidant activity in liver tissues compared with the CP group. The upregulated hepatic levels of TLR2/4 and their downstream signaling molecules including c-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NF-κB) were also suppressed by NaHS protective treatment. NaHS showed anti-inflammatory and antiapoptotic effects; reducing hepatic level tumor necrosis factor-alpha (TNF-α) and caspase-3 expression. Interestingly, the cytotoxic events induced in CP-treated rats were not significantly altered upon the blocking of endogenous H2S. Taken together, the present study suggested that exogenously applied H2S rather than the endogenously generated H2S, displayed a hepatoprotective effect against CP-induced hepatotoxicity that might be mediated by TLRs-JNK/NF-κB pathways.

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“…A number of SNPs for TLR9 have been identified, and two of these SNPs, rs187084 (A1486G) and rs352140 (C2848T), are often reported to influence susceptibility or resistance to infections ( Hemmi et al., 2000 ; Ferwerda et al., 2007 ). TLR9 A1486G carriers have been found to be associated with a decreased risk of Acinetobacter baumannii in a Chinese population ( He et al., 2016 ), and the C2848T polymorphism is significantly positively related to neonatal severe hepatitis among Chinese newborns ( Qiu et al., 2018 ). Moreover, allele C on T-1237C (TLR9) was associated with susceptibility to allergic bronchopulmonary aspergillosis ( Carvalho et al., 2008 ).…”

Section: Discussionmentioning

confidence: 99%

The Association of TLR2, TLR3, and TLR9 Gene Polymorphisms With Susceptibility to Talaromycosis Among Han Chinese AIDS Patients in Guangdong

Wang

Xiao

et al. 2021

Front. Cell. Infect. Microbiol.

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BackgroundTalaromycosis (TM) caused by Talaromyces marneffei (T. marneffei) is a growing public health concern. Although Toll-like receptor (TLR) genes play a critical role in the host defense against fungal infection, the influence of polymorphisms in these genes on the susceptibility of acquired immune deficiency syndrome (AIDS) patients to TM remains unknown. This study aims to uncover the associations of single nucleotide polymorphisms (SNPs) in TLR genes with TM susceptibility among patients with AIDS.MethodsAltogether 200 AIDS patients complicated with TM, 200 matched AIDS patients without TM, and 76 healthy controls (HCs) were enrolled in this case-control study. In total, 23 SNPs in the TLR2, TLR4, and TLR9 genes, which may influence the susceptibility of AIDS patients to TM, were checked by the time of flight mass spectrometry (TOF/MS) method among these Han Chinese subjects.ResultsNo significant differences in genotype or allele frequencies of selected SNPs were found among the TM group, Non-TM group, and HC group. Haplotype analysis also demonstrated no correlation of these SNPs with TM. However, subgroup analysis showed that the genotype TT and the T allele in TLR2 SNP rs1339 were more frequent in typical TM cases than controls (50.0 vs. 35.8%, 70.5 vs. 59.7%); the frequency of the GT genotype in TLR2 SNP rs7656411 was markedly higher in severe TM cases compared to controls (57.8 vs. 34.4%).ConclusionOur results demonstrate a genetic connection of TLR2 SNPs rs1339 and rs7656411 with an increased susceptibility and severity of TM among Han Chinese populations.

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Correlation between TLR2,TLR3,TLR4, and TLR9 polymorphisms and susceptibility to and prognosis of severe hepatitis among the newborns

Abstract: Certain SNPs and haplotypes within TLR2, TLR3, TLR4, and TLR9 can be considered as the potentially treatment targets for neonatal severe hepatitis.

Cited by 9 publications

References 29 publications

The Relationship of TLR2 Polymorphisms with Infectious Diseases

The Relationship of TLR2 Polymorphisms with Infectious Diseases

TLRs-JNK/ NF-κB Pathway Underlies the Protective Effect of the Sulfide Salt Against Liver Toxicity

The Association of TLR2, TLR3, and TLR9 Gene Polymorphisms With Susceptibility to Talaromycosis Among Han Chinese AIDS Patients in Guangdong

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