Correlation between IL-10 Expression with Histopathology Type on Nasopharyngeal Carcinoma Patients

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a malignancy derived from lymphoepithelial tissue and nasopharyngeal epithelial cells. The response therapy of NPC evaluated from histopathological type, but in some patients with the same type was illustrated a different response of therapy. IL-10 expression expects to predict a better response therapy of NPC. IL-10 expression by immunohistochemical examination associated with the differentiation of tumors. Method:The study was analytic observational with the cross-sectional approach. Samples were collected by consecutive sampling and formalin-fixed, paraffin-embedded biopsy specimens were obtained. Result:The result of IL-10 expression in Nasopharyngeal carcinoma (NPC) patients with histopathological World health organization (WHO) type I was obtained; From all the samples, there were 36.36% of strong positive expression and 63.64% of frail positive expression. There were increases in the number of cells that give a strong expression on WHO type III. Statistical analysis using Fisher's exact test was obtained p = 0.040 with a contingency coefficient of 0.384. Conclusion:There was a moderate correlation between IL-10 expression and histopathological type in NPC patients.