Correlation between images of silent brain infarction, carotid atherosclerosis and white matter hyperintensity, and plasma levels of acrolein, IL-6 and CRP

Yoshida, Madoka; Higashi, Kyohei; Kobayashi, Eiichi; Saeki, Naokatsu; Wakui, Kenji; Kusaka, Tadafumi; Takizawa, Hirotaka; Kashiwado, Koichi; Suzuki, Norikazu; Fukuda, Kazumasa; Nakamura, Toshio; Watanabe, Sakae; Tada, Kei; Machi, Yoshiki; Mizoi, Mutsumi; Toida, Toshihiko; Kanzaki, Tetsuto; Tomitori, Hideyuki; Kashiwagi, Keiko; Igarashi, Kazuei

doi:10.1016/j.atherosclerosis.2010.03.031

Cited by 57 publications

(44 citation statements)

References 28 publications

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“…PC-Acro, IL-6 and CRP were significantly higher in SBI and CA compared with the control. PC-Acro was most strongly associated with CA, and IL-6 and CRP with SBI [49]. Thus, CA is likely the primary risk factor related with stroke in this analysis.…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 89%

“…Accordingly, the median RRV of 175 mild subjects and 88 severe subjects was 0.67 and 0.90, respectively. With an increase in severity, from mild to severe, the association with SBI increased from 30 to 45% [49].…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 96%

“…Thus, RRV for the subjects with PVH or DSWMH and with both PVH and DSWMH was 0.34 and 0.55, respectively. With an increased severity of WMH, the association with SBI increased from 3.6 to 10% [49].…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 97%

“…6B). In this case, SBI, CA and WMH include subjects with single, double and triple pathologies [49].…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 99%

“…Since the levels of CRP and IL-6 are reported to increase in the serum of apparently healthy individuals with SBI [47], we measured the levels of CRP and IL-6 along with PC-Acro in plasma [48,49]. SBI (affected areas Z3 mm diameter) and WMH were estimated by MRI, CA by carotid ultrasound examination and CRP and IL-6 in plasma by ELISA.…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 99%

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Protein‐conjugated acrolein as a biochemical marker of brain infarction

Igarashi

Kashiwagi

2011

Molecular Nutrition Food Res

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The relationship between acrolein (CH(2) =CH-CHO) and brain infarction is the focus of this review. It has been found that acrolein is produced mainly within cells from polyamines by polyamine oxidases (PAOs), especially from spermine by spermine oxidase during cell damage, and that acrolein is more toxic than reactive oxygen species (ROS) in a cell culture system. Thus, the possibility that acrolein and PAOs are good biochemical markers of stroke was tested because there are no other reliable biochemical markers at the early stage of stroke. Levels of protein-conjugated acrolein (PC-Acro) and PAOs (acrolein-producing enzymes) were significantly increased in the plasma of stroke patients. The multiplied value of PC-Acro by PAOs was nearly parallel with the size of stroke. Furthermore, when the combined measurements of PC-Acro, interleukin-6 (IL-6) and C-reactive protein (CRP) were evaluated along with age using a receiver operating characteristic (ROC) curve, even silent brain infarction (SBI), which is a small brain infarction, was indicated with approximately 84% sensitivity and specificity. These findings clearly indicate that acrolein is strongly correlated with cell damage during brain infarction.

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Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 89%

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 96%

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 97%

“…6B). In this case, SBI, CA and WMH include subjects with single, double and triple pathologies [49].…”

Section: Detection Of Silent Brain Infarction (Sbi)mentioning

confidence: 99%