Correlation between immune response and self-reported depression during convalescence from COVID-19

Yuan, Bo; Li, Weixin; Liu, Hanqing; Cai, Xin; Song, Shuo; Zhao, Jiuliang; Hu, Xiaopeng; Li, Zhiwen; Chen, Yongxin; Zhang, Kai; Li, Yong; Peng, Jing; Wang, Cheng; Wang, Jianchun; An, Yu

doi:10.1016/j.bbi.2020.05.062

Cited by 89 publications

(82 citation statements)

References 25 publications

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“…Given the great influence of COVID-19 on people globally, investigating how COVID-19 may affect the mental health of people is an urgent issue. Precious studies have investigated how the COVID-19 crisis, particularly the lockdown and quarantine policies, affects people’s mental health [ 1 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. However, few studies have shown how the risk perception of COVID-19 may affect people’s mental health.…”

Section: Literature Reviewmentioning

confidence: 99%

Risk Perception and Depression in Public Health Crises: Evidence from the COVID-19 Crisis in China

Ding

Huang

et al. 2020

IJERPH

134

116

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Background: Scant attention has been paid to how risk perceptions of public health crises may affect people’s mental health. Aims: The aims of this study are to (1) construct a conceptual framework for risk perception and depression of people in public health crises, (2) examine how the mental health of people in the crisis of Coronavirus Disease 2019 (COVID-19) is affected by risk perception and its associated factors, including distance perception of the crisis and support of prevention and control policies, and (3) propose policy recommendations on how to deal with psychological problems in the current COVID-19 crisis. Methods: Online questionnaire survey was implemented. A total of 6373 people visited the questionnaire online, 1115 people completed the questionnaire, and the number of valid questionnaires was 1081. Structural equation modeling was employed for data analysis. Results: Risk perception and its associated factors significantly affect the mental health of people in public health crises. Specifically, (1) distance perception of public health crises is negatively associated with depression among people, (2) affective risk perception is positively associated with depression of people in public health crises, (3) cognitive risk perception is negatively associated with depression of people in public health crises, and (4) support of prevention and control policies is negatively associated with depression of people in public health crises. Conclusion: The findings of this study suggest that risk perception plays an important role in affecting the mental health of people in a public health crisis. Therefore, health policies aiming to improve the psychological wellbeing of the people in a public health crisis should take risk perception into consideration.

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Section: Literature Reviewmentioning

confidence: 99%

Risk Perception and Depression in Public Health Crises: Evidence from the COVID-19 Crisis in China

Ding

Huang

et al. 2020

IJERPH

134

116

View full text Add to dashboard Cite

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“…There is also evidence of prevalent depressive symptoms in those already recovered from COVID-19 (Cai et al, 2020;Yuan et al, 2020;Zhang et al, 2020). A study of 126 COVID-19 survivors in convalescence from Shenzhen, China, showed that self-reported anxiety and depression were common after discharge from hospital (Cai et al, 2020) and moreover, depressive symptoms were associated with immune systemic suppression, based on increased white blood cells and inflammatory factors measures (Yuan et al, 2020).…”

Section: Neuropsychiatric Manifestations Of Covid-19mentioning

confidence: 99%

Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals With Dementia

Alonso‐Lana

Marquié

Ruiz

et al. 2020

Front. Aging Neurosci.

150

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The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide and has had unprecedented effects in healthcare systems, economies and society. COVID-19 clinical presentation primarily affects the respiratory system causing bilateral pneumonia, but it is increasingly being recognized as a systemic disease, with neurologic manifestations reported in patients with mild symptoms but, most frequently, in those in a severe condition. Elderly individuals are at high risk of developing severe forms of COVID-19 due to factors associated with aging and a higher prevalence of medical comorbidities and, therefore, they are more vulnerable to possible lasting neuropsychiatric and cognitive impairments. Several reports have described insomnia, depressed mood, anxiety, post-traumatic stress disorder and cognitive impairment in a proportion of patients after discharge from the hospital. The potential mechanisms underlying these symptoms are not fully understood but are probably multifactorial, involving direct neurotrophic effect of SARS-CoV-2, consequences of long intensive care unit stays, the use of mechanical ventilation and sedative drugs, brain hypoxia, systemic inflammation, secondary effects of medications used to treat COVID-19 and dysfunction of peripheral organs. Chronic diseases such as dementia are a particular concern not only because they are associated with higher rates of hospitalization and mortality but also because COVID-19 further exacerbates the vulnerability of those with cognitive impairment. In patients with dementia, COVID-19 frequently has an atypical presentation with mental status changes complicating the early identification of cases. COVID-19 has had a dramatical impact in long-term care facilities, where rates of infection and mortality have been very high. Community measures implemented to slow the spread of the virus have forced to social distancing and cancelation of cognitive stimulation programs, which may have contributed to generate loneliness, behavioral symptoms and worsening of cognition in patients with dementia. COVID-19 has impacted the functioning of Memory Clinics, research programs and clinical trials in the Alzheimer's field, triggering the

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“…The patient could rate each question from 0 to 3 to provide a severity score ranging from 0 to 27. We de ned depression severity as being no depression (1-4), mild depression (5-9), moderate depression (10)(11)(12)(13)(14), moderately severe depression (15)(16)(17)(18)(19), and severe depression (20)(21)(22)(23)(24)(25)(26)(27). We considered signi cant depression to be present when the total score was 10 or higher.…”

Section: Methodsmentioning

confidence: 99%

“…Psychological morbidities, including PTSD, anxiety, and depression, were reported to be common in COVID-19 patients [12]. Additionally, immune function changes correlated with self-reported depression during short-term follow-up of COVID-19 patients following discharge from the hospital [19].…”

Section: Introductionmentioning

confidence: 91%

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Predictors of Psychiatric Disorders or uses of Psychotropic Drugs in Patients with Confirmed COVID-19 During Treatment in a Hospital : A Retrospective Chart Review Running title : Mental health of COVID-19 patients

Kim

Han

Lee

2020

Preprint

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BackgroundThis study aims to examine the psychiatric diagnoses, psychotropic drug use, and related factors in patients with coronavirus disease-19 (COVID-19) during their acute treatment phase.MethodsWe performed a retrospective chart review of patients admitted to the isolation ward at a nationally designated hospital during the COVID-19 outbreak. All the COVID-19 patients admitted to the hospital were assigned to psychiatrists by consultation in order to monitor their mental health during their hospital stay. We analyzed the medical records and self-reported psychological tests of 80 out of 112 patients.ResultsOn admission, 16.3% of the subjects had self-reported depression and 6.3% had post-traumatic stress disorder (PTSD). Twenty-five patients (31.3%) had current diagnoses of mental disorders. These disorders consisted of nonorganic insomnia, acute stress reaction, panic disorder, and depressive episodes. Nineteen patients (23.8%) were prescribed psychotropic drugs, including trazodone, alprazolam, clonazepam, and zolpidem. Factors associated with these psychiatric diagnoses included self-reported PTSD on the day of admission and having a spouse. Previous psychiatric history and age of 40 years or more were associated with the use of psychotropic drugs.ConclusionMental health services rendered to quarantined COVID-19 patients undergoing an acute treatment phase and self-reported PTSD on the day of admission might be useful in predicting mental health problems during hospital days.

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Correlation between immune response and self-reported depression during convalescence from COVID-19

Cited by 89 publications

References 25 publications

Risk Perception and Depression in Public Health Crises: Evidence from the COVID-19 Crisis in China

Risk Perception and Depression in Public Health Crises: Evidence from the COVID-19 Crisis in China

Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals With Dementia

Predictors of Psychiatric Disorders or uses of Psychotropic Drugs in Patients with Confirmed COVID-19 During Treatment in a Hospital : A Retrospective Chart Review Running title : Mental health of COVID-19 patients

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