Correlation between Immunological Parameters and Cutaneous Manifestations of Systemic Lupus erythematosus

Abstract

A patient with systemic lupus erythematosus with predominant skin involvement is described. A good correlation between disease activity manifested by skin lesions and between the titer of anti-DNA antibodies and C 3 component of complement was observed. Disease activity was accompanied by a high titer of anti-DNA antibodies and by a low level of the C3 component of complement; these parameters were reversed during remission. We conclude that these parameters are useful in the diagnosis and management of patients with systemic lupus erythematosus limited to the skin.

Correlation between anti-DNA antibody titre and psychiatric manifestations in systemic lupus erythematosus

“…A good correlation between high anti-DNA antibody titres and low complement levels was observed during periods of active renal or cutaneous involvement in SLE patients (Oyama, 1971;Levo et al, 1973). The pathogenesis of central nervous system (CNS) involvement in SLE is possibly based on the same mechanisms (Bennett et al, 1972;Baker et al, 1974;Petz et al, 1971;Hadler et al, 1973;Keeffe, Baradana and Harbeck, 1974;Harbeck et al, 1973;Levin et al, 1972;Atkins et al, 1972;Bennahum and Messner, 1975).…”