Correlation between in vitro and in vivo erosion behaviour of erodible tablets using gamma scintigraphy

Ghimire, Manish; Hodges, Lee Ann; Band, Janet; Lindsay, Blythe; O'Mahony, Bridget; McInnes, Fiona; Mullen, Alexander B.; Stevens, H. N. E.

doi:10.1016/j.ejpb.2010.10.005

Cited by 13 publications

(4 citation statements)

References 32 publications

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“…Many studies have reported the gastric emptying times of nondisintegrating dosage forms in the fasted state. [4][5][6][7][8][9] The median gastric emptying times of monolithic dosage forms in these studies were slower than those observed in our present study. Generally, gastric emptying of solid materials bigger than a couple of millimeters is limited under the fasting condition.…”

Section: Gastrointestinal Transit Of Radiolabeled Hydrogel Matrix Tabletcontrasting

confidence: 71%

“…This radionuclide scintigraphy approach has been widely used to characterize GI transit of oral dosage forms in humans. [4][5][6] More recently, magnetic marker monitoring methods have been introduced and the GI transit characteristics of magnetically labeled solid dosage forms have been reported in the literature. 7,8 Furthermore, telemetric capsules such as SmaprtPill® (Medtronic, Minneapolis, MN) and IntelliCap® (Medimetrics, Eindhoven, Netherlands), which can record pH, temperature, and so forth, have been used to characterize the GI transit of these capsules in humans.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Diurnal Variation and Food on Gastrointestinal Transit of 111In-Labeled Hydrogel Matrix Extended-Release Tablets and 99mTc-Labeled Pellets in Humans

Kambayashi

Sako²,

Kondo

2020

Journal of Pharmaceutical Sciences

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Section: Gastrointestinal Transit Of Radiolabeled Hydrogel Matrix Tabletcontrasting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Effects of Diurnal Variation and Food on Gastrointestinal Transit of 111In-Labeled Hydrogel Matrix Extended-Release Tablets and 99mTc-Labeled Pellets in Humans

Kambayashi

Sako²,

Kondo

2020

Journal of Pharmaceutical Sciences

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“…16.9) [46,47]. Ghimire et al have reported the use of gamma scintigraphy for quantitative assessment of erosion in vivo (Fig.…”

Section: In Vivo Erosion and Formulation Robustnessmentioning

confidence: 99%

IN VIVO IMAGING FOR VALIDATION OF ORAL DOSE PERFORMANCE

McInnes¹,

Stevens²

2013

Drug Delivery Applications of Noninvasive Imaging

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“…Colon targeted drug delivery systems have been visualized widely using gamma scintigraphy in the literature where the tablet integrity is lost in the colon. 32 In the present study x-ray imaging studies showed gradual reduction in the size of the tablet with time until it disappeared completely (Table 7).…”

mentioning

confidence: 93%

Colon Specific Drug Delivery: Effect of Eudragit Enteric Coating on Hydroxypropyl Methylcellulose Matrix Tablets of Flurbiprofen

Vemula¹

2015

JYP

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Objective: The present research is focused on developing flurbiprofen colon-specific tablets based on timed release and pH-sensitivity. Methods and Material: This study is designed to study the effect of eudragit coating on the drug release from hydroxypropyl methylcellulose matrix to achieve the colon-specific release. Hydroxypropyl methylcellulose matrix tablets were prepared by wet granulation method and coated with eudragit S100 using dip coating method. Then the tablets were evaluated for different physical parameters, compatibility studies, in vitro dissolution and in vivo x-ray imaging studies. Statistical Analysis: In the stability studies, paired t-test is employed to determine the significance of difference at 0.05 level. Results: Flurbiprofen colon-specific tablets have been characterized for weight variation, hardness, friability and drug content. Based on in vitro drug release, the formulation F6 showed the low amount of drug release (18.41 ± 0.68%) in the initial lag period followed 100.43 ± 3.33% in 24 h. Compatibility studies revealed that there was no interaction between drug and the polymers. Similarity index value was found as 95.01, which is more than 50 indicates similarity between the dissolution profile before and after storage. In support of the dissolution studies, x-ray imaging studies revealed that tablets reached the colon without disintegrating in the upper gastro intestinal tract. Conclusion: From the above results, it is obvious that the developed flurbiprofen enteric coated matrix tablets are suitable for colonic delivery.

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Correlation between in vitro and in vivo erosion behaviour of erodible tablets using gamma scintigraphy

Cited by 13 publications

References 32 publications

Effects of Diurnal Variation and Food on Gastrointestinal Transit of 111In-Labeled Hydrogel Matrix Extended-Release Tablets and 99mTc-Labeled Pellets in Humans

Effects of Diurnal Variation and Food on Gastrointestinal Transit of 111In-Labeled Hydrogel Matrix Extended-Release Tablets and 99mTc-Labeled Pellets in Humans

IN VIVO IMAGING FOR VALIDATION OF ORAL DOSE PERFORMANCE

Colon Specific Drug Delivery: Effect of Eudragit Enteric Coating on Hydroxypropyl Methylcellulose Matrix Tablets of Flurbiprofen

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