Correlation Between Inflammatory and Biochemical Parameters in Patients with Diabetes and Urinary Tract Infection

Bureković, Azra; Hasković, Edhem; Ceric, Faruk; Halilovic, Dzenana

doi:10.5455/msm.2021.33.240-243

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…In all of these scenarios, different Candida species have a prominent role[ 6 , 86 ]. In addition, in patients with diabetes, the duration of disease and poor glycoregulation in the long run lead to changes in the kidney’s microvasculature and frequent polyuria/glycosuria, which can predispose them to more frequent urinary tract infections[ 87 ].…”

Section: Types Of Urogenital Candidiasis In Patients With Diabetesmentioning

confidence: 99%

Growing importance of urogenital candidiasis in individuals with diabetes: A narrative review

Talapko¹,

Meštrović²,

Škrlec³

2022

World J Diabetes

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Both diabetes and fungal infections contribute significantly to the global disease burden, with increasing trends seen in most developed and developing countries during recent decades. This is reflected in urogenital infections caused by Candida species that are becoming ever more pervasive in diabetic patients, particularly those that present with unsatisfactory glycemic control. In addition, a relatively new group of anti-hyperglycemic drugs, known as sodium glucose cotransporter 2 inhibitors, has been linked with an increased risk for colonization of the urogenital region with Candida spp., which can subsequently lead to an infectious process. In this review paper, we have highlighted notable virulence factors of Candida species (with an emphasis on Candida albicans ) and shown how the interplay of many pathophysiological factors can give rise to vulvovaginal candidiasis, potentially complicated with recurrences and dire pregnancy outcomes. We have also addressed an increased risk of candiduria and urinary tract infections caused by species of Candida in females and males with diabetes, further highlighting possible complications such as emphysematous cystitis as well as the risk for the development of balanitis and balanoposthitis in (primarily uncircumcised) males. With a steadily increasing global burden of diabetes, urogenital mycotic infections will undoubtedly become more prevalent in the future; hence, there is a need for an evidence-based approach from both clinical and public health perspectives.

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Section: Types Of Urogenital Candidiasis In Patients With Diabetesmentioning

confidence: 99%

Growing importance of urogenital candidiasis in individuals with diabetes: A narrative review

Talapko¹,

Meštrović²,

Škrlec³

2022

World J Diabetes

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“…To date, albuminuria or proteinuria is the main index of clinical diagnosis of DN [6,7], but their test results are easily affected by many factors, such as high fat intake [8], strenuous exercise [9], insulin resistance [10], hypertension [11], and urinary tract infection [12]. In addition, due to the occult onset of DN, although some patients have advanced renal pathological changes, the level of urinary albumin is still within the normal range [7].…”

Section: Introductionmentioning

confidence: 99%

Urinary FBP1 as a novel biomarker for the diagnosis and progression of diabetic nephropathy

Zhang

Wang

Liu

et al. 2023

Preprint

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Background: The pathogenesis of diabetic nephropathy (DN) is complex, and its onset is occult. It should be considered from multiple levels and angles using the concept of "system biology". New technologies, such as omics and high-throughput screening, provide more strategies for the screening of ideal markers of DN. Methods: we used data-independent acquisition (DIA) mass spectrometry for urine proteomic analysis of DN patients at different pathological stages and healthy controls. Results: Fructose-1,6-bisphosphatase 1 (FBP1) was specifically found in the urine of DN patients but not in that of healthy controls. Then, ELISA demonstrated that the urinary level of FBP1 in DN patients was significantly higher than that in healthy controls. We further verified the higher levels of urine FBP1 in association with DN than in association with type 2 diabetes mellitus (T2DM) and nondiabetic nephropathy. Receiver operating characteristic (ROC) curve analysis showed that FBP1 can distinguish DN and T2DM patients, and the AUC was 0.889 (sensitivity: 80%, specificity: 85%). Correlation analysis revealed that the level of urinary FBP1 was positively correlated with the progression of DN, as reflected by the fact that urinary FBP1 was negatively correlated with e-GFR and positively correlated with urea nitrogen, the interstitial inflammation score, and the interstitial fibrosis and tubular atrophy (IFTA) score. Conclusions: The source of urinary FBP1 was traced, and it was revealed that it was specifically reduced in proximal renal tubules with the progression of DN, supporting the view that urinary FBP1 can be used as a marker for the progression of diabetic nephropathy. Together, our results indicate that FBP1 might not only be a novel marker for the diagnosis of DN but also be a new marker for the progression of DN.

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Correlation Between Inflammatory and Biochemical Parameters in Patients with Diabetes and Urinary Tract Infection

Cited by 2 publications

References 12 publications

Growing importance of urogenital candidiasis in individuals with diabetes: A narrative review

Growing importance of urogenital candidiasis in individuals with diabetes: A narrative review

Urinary FBP1 as a novel biomarker for the diagnosis and progression of diabetic nephropathy

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