Correlation between inhibitory effect on prolactin secretion and antitumor activity of new ergoline compounds on DMBA-induced tumors in rats

Formelli, Franca; Zaccheo, T.; Salle, E. Di; Ornati, G.; Marco, A. Di

doi:10.1016/0277-5379(83)90084-6

Cited by 14 publications

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“…There have been extensive studies that demonstrate the important role of PRL in mammary tumorigenesis, both in the development of spontaneous mammary tumors in mice and rats as well as in the induction and development of DMBA-induced mammary carcinomas in rats. It was also documented that these are PRL-dependent tumors; thus an increase in PRL secretion frequently promotes tumor growth, whereas a decrease or inhibition of PRL secretion by anti-PRL ergoline derivatives is usually followed by tumor regression (5,6,11).…”

Section: Discussionmentioning

confidence: 99%

“…Estrogens act mainly by stimulation of PRL secretion and in conjunction with PRL in mammary tumorigenesis (1,2). H ypothalamic lesions, pituitary grafts, or drugs (biogenic amines) that suppress PRL secretion can either stimulate or inhibit the development of spontaneous or carcinogen-induced mammary tumors in rats or mice (5,6). Although most data suggest that PRL plays an important role in DMBAinduced mammary tumors in rats (2,(7)(8)(9), the role of PRL is less important in N -nitroso-N -methylureainduced mammary tumors in rats, which are histologically similar to DMBA-induced tumors (10,11).…”

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Enhancement of Epidermal Carcinoma Formation by Prolactin in Mice

1985

JNCI: Journal of the National Cancer Institute

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Long-term administration of prolactin (PRL) markedly enhanced the induction of epidermal squamous cell carcinomas by a chemical carcinogen, 3-methylcholanthrene [(MCA) CAS: 56-49-5], in Swiss male albino mice. DNA radioactivity and quantitative estimation of autoradiographs with the use of [3H]thymidine revealed a significant increase in DNA content (twofold) and in the percentage of labeled neoplastic nuclei in mice treated with PRL plus MCA (48.50%) as compared to that in mice treated with MCA alone (23.50%). Ultrastructural and cytologic studies revealed the predominance of a trabecular-hepatoid type of epidermal carcinoma with advanced nuclear irregularities, glycogen granules, mirror-image cells, and phagolysosomes in PRL-MCA-treated carcinomas as compared to characteristic squamous neoplastic cells with enlarged nuclei, tonofilaments, and keratin formation in epidermal carcinomas following treatment with MCA alone. Scanning electron microscopy revealed the predominance of rounded cells covered by numerous thick microvilli and blebs with an intense stromal reaction following PRL-MCA administration as compared to characteristic polyhedral cells covered by small microvilli following treatment with MCA alone. These findings demonstrate that PRL is an important hormone in epidermal neoplastic cell growth and differentiation.-JNCI 1985; 74:1335-1346.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%