Correlation between insight dimensions and cognitive functions in patients with deficit and nondeficit schizophrenia

Pegoraro, Luiz Fernando; Dantas, Clarissa de Rosalmeida; Banzato, Cláudio E. M.; Fuentes, Daniel

doi:10.1016/j.schres.2013.02.041

Cited by 24 publications

(14 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, we found that cognitive function in medicated patients with deficit syndrome did not differ from that of medicated patients with non-deficit syndrome. However, previous reports showed that patients with deficit syndrome suffer a more severe degree of neurocognitive impairment relative to patients with non-deficit syndrome (Réthelyi et al, 2012;Pegoraro et al, 2013;Csukly et al, 2014). The reasons underlying this difference are currently unknown.…”

Section: Discussionmentioning

confidence: 95%

Impaired processing speed and attention in first-episode drug naive schizophrenia with deficit syndrome

Chen

Jiang

Zhong

et al. 2014

Schizophrenia Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Impaired processing speed and attention in first-episode drug naive schizophrenia with deficit syndrome

Chen

Jiang

Zhong

et al. 2014

Schizophrenia Research

View full text Add to dashboard Cite

“…In schizophrenia, both better working memory and better verbal comprehension were ever reported to be associated with greater insight, which is defined as the awareness of having a mental disorder and need for treatments (16, 53, 54). It was thought that more insight into the disorder could contribute to increased hopelessness and depression, then leading to suicide (2).…”

Section: Discussionmentioning

confidence: 99%

Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia

et al. 2018

View full text Add to dashboard Cite

Objective: The study was aimed to investigate the possible associations among suicidal ideation, brain white matter (WM) integrity and cognitive deficit in first-episode schizophrenia (FES) using diffusion tensor imaging.Methods: The sample contained 18 FES patients with suicidal ideation (SI+), 45 FES patients without suicidal ideation (SI–) and 44 healthy controls. The Calgary Depression Scale for Schizophrenia was used to measure the suicidal ideation and depression symptoms. The whole brain WM integrity and three domains of cognitive function: working memory, verbal comprehension as well as processing speed were compared between the three groups.Results: Compared with SI–, SI+ showed preserved WM integrity as indicated by significantly higher factional anisotropy (FA) or lower mean diffusivity (MD) in multiple WM tracts, and higher FA coupled with lower MD in bilateral posterior corona radiata. Compared with SI−, SI+ were more depressed and had less cognitive deficit in working memory and verbal comprehension. The fiber tracts in bilateral posterior corona radiata connect to the precuneus as shown by probabilistic tractography, and their WM integrity disruptions were found to be positively associated with the cognitive deficits in the FES patients.Discussion: Preserved WM integrity may be a risk factor for suicidal ideation in FES patients. One possible explanation is that it contributes to preserved cognitive function, especially in working memory and verbal comprehension, which may be associated with greater insight and could lead to increased depression and suicidal ideation. The posterior corona radiata and the precuneus may be linked to the related biological processes.

show abstract

“…For example, several studies reported a more severe deficit of cognitive flexibility in DS patients relative to NDS patients using Trail Making Test Part B (TMT-B) and Stroop interference measure [ 23 , 24 , 26 – 28 ], while discrepant results were reported from a group comparison based on the flexibility index of TMT-B minus TMT-A [ 11 , 17 ] and Continuous Performance Test (CPT) [ 11 , 17 , 18 , 22 ]. Again, although poorer competence of sustained attention [ 20 , 24 ] and visuospatial memory [ 27 , 29 ] in DS patients were found compared with NDS patients, some studies argued against a specific impairment in those two cognitive domains in DS patients [ 11 , 17 , 22 , 25 , 27 ]. The inconsistencies of these various reports do not allow a congruent understanding of the characteristic neurocognitive profile of DS, which might be attributed to the various clinical and methodological factors including variation of psychiatric symptoms severity, small sample size and different neuropsychological assessment tools.…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive Impairments in Deficit and Non-Deficit Schizophrenia and Their Relationships with Symptom Dimensions and Other Clinical Variables

Tang²,

Wang

et al. 2015

PLoS ONE

View full text Add to dashboard Cite

BackgroundDeficit schizophrenia (DS) has been proposed as a pathophysiologically distinct subgroup within schizophrenia. Earlier studies focusing on neurocognitive function of DS patients have yielded inconsistent findings ranging from substantial deficits to no significant difference relative to non-deficit schizophrenia patients (NDS). The present study investigated the severity and characteristic patterns of neurocognitive impairments in DS and NDS patients and their relationships with clinical variables.MethodsAttention, ideation fluency, cognitive flexibility and visuospatial memory function were assessed in 40 DS patients, 57 NDS patients, and 52 healthy controls by a comprehensive neuropsychological battery.ResultsBoth schizophrenia subgroups had overall more severe cognitive impairments than controls while DS performed worse on every neuropsychological measure except the Stroop interference than the NDS patients with age and education as the covariates. Profile analysis found significantly different patterns of cognitive profiles between two patients group mainly due to their differences in attention and cognitive flexibility functions. Age, education, illness duration and negative symptoms were found to have the correlations with cognitive impairments in the NDS group, while only age and the negative symptoms were correlated with the cognitive impairments in the DS group. Multiple regression analyses revealed that sustained attention and cognitive flexibility were the core impaired cognitive domains mediating other cognitive functions in DS and NDS patients respectively.ConclusionsDS patients exemplified worse in almost all cognitive domains than NDS patients. Sustained attention and cognitive flexibility might be the key impaired cognitive domains for DS and NDS patients respectively. The present study suggested the DS as a specific subgroup of schizophrenia.

show abstract

Correlation between insight dimensions and cognitive functions in patients with deficit and nondeficit schizophrenia

Cited by 24 publications

References 30 publications

Impaired processing speed and attention in first-episode drug naive schizophrenia with deficit syndrome

Impaired processing speed and attention in first-episode drug naive schizophrenia with deficit syndrome

Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia

Neurocognitive Impairments in Deficit and Non-Deficit Schizophrenia and Their Relationships with Symptom Dimensions and Other Clinical Variables

Contact Info

Product

Resources

About