Correlation between lethality and DNA single-strand breaks in Bacillus subtilis cells treated with N-methyl-N′-nitro-N-nitrosoguanidine

Dugle, D.L.; Campbell, C.E.; Meeker, B. E.; Gillespie, C.J.

doi:10.1016/0027-5107(73)90206-6

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

1973

DOI: 10.1016/0027-5107(73)90206-6

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Correlation between lethality and DNA single-strand breaks in Bacillus subtilis cells treated with N-methyl-N′-nitro-N-nitrosoguanidine

D.L. Dugle¹,

C.E. Campbell²,

B. E. Meeker³

et al.

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1974

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Cited by 5 publications

References 21 publications

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Recombinational repair of alkylation lesions in phage T4

Schneider

Bernstein

1978

Molec. Gen. Genet.

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Treatment of phage T4-host adsorption complexes by MNNG increased recombination between two rII markers by about three-fold. Temperature sensitive mutants defective in genes 32, 46 and 47, which cause reductions in recombination at semirestrictive temperature, proved to be substantially more sensitive to MNNG at such temperatures than wild-type phage. In addition, the recombination defective mutants xm(uvsX) and y10(y) were sensitive to MNNG than wild-type, whereas mutants defective in genes 45 and denV, which are apparently not involved in recombination, were not MNNG sensitive. These findings suggest that a recombination pathway involving the products of genes 32, 46, 47, uvsX and y is employed in repairing MNNG-induced lethal lesions. This mechanism is effective in cells infected by single phage, implying post-replication recombinational repair between daughter chromosomes. MNNG-induced lesions are subjects to multiplicity reactivation, but mutants defective in genes 46 to 47 showed the same degree of multiplicity reactivation as wild-type phage. The gene 32 and gene 47 recombination defective mutants were tested for their effects of MNNG-induced reversion of an rII marker. No reduction in induced reversion was found. Thus, it appears that the postulated recombinational repair pathway employing the products of genes 32 and 47 does not contribute substanitally to induced mutagenesis.

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Recombinational repair of alkylation lesions in phage T4

Schneider

Bernstein

1978

Molec. Gen. Genet.

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Effect of N-nitroso-N-methylurea on viability and mutagenic response of repair-deficient strains of Escherichia coli

Hince

Neale

1974

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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Mutagenicity of nitrosamides and nitrosamidines in micro-organisms and plants

Neale

1976

Mutation Research/Reviews in Genetic Toxicology

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Correlation between lethality and DNA single-strand breaks in Bacillus subtilis cells treated with N-methyl-N′-nitro-N-nitrosoguanidine

Cited by 5 publications

References 21 publications

Recombinational repair of alkylation lesions in phage T4

Recombinational repair of alkylation lesions in phage T4

Effect of N-nitroso-N-methylurea on viability and mutagenic response of repair-deficient strains of Escherichia coli

Mutagenicity of nitrosamides and nitrosamidines in micro-organisms and plants

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