Correlation between leukocyte count and infarct size in ST segment elevation myocardial infarction

Abstract

IntroductionRegarding the inflammatory mechanisms involved in ischemic heart disease, currently the leukocyte count is the subject of studies related to its association with the prognosis and mortality of ST segment elevation myocardial infarction (STEMI). Our aim is correlate the leukocyte count rise with the size of STEMI, evaluated with the area under the curve (AUC) and the peak of necrosis markers release.Material and methodsThis study is a sub-analysis of the TETHYS trial, a clinical trial that evaluated the effects of methotrexate in STEMI. We evaluated the correlation between quantitative variables with Pearson’s correlation, and the variables that did not follow a normal distribution were subjected to logarithmic transformation to base 10. The value of p < 0.05 indicated statistical significance.ResultsMales accounted for 73% of the participants, who had an average age of 59 years. A total of 58% were hypertensive and 53% smokers. The leukocyte count at hospital admission was significantly correlated with the AUC creatine kinase (CK) (r = 0.256, p = 0.021), troponin AUC (r = 0.247, p = 0.026), peak CK (r = 0.270, p = 0.015) and troponin peak (r = 0.233, p = 0.037). The leukocyte count at 72 h was significantly correlated with CK AUC (r = 0.238, p = 0.032), AUC of MB portion of CK (r = 0.240, p = 0.031) and peak CK (r = 0.224, p = 0.045).ConclusionsWhite blood cell count correlates with STEMI size assessed by serial cardiac biomarker levels.

HIV-infected patients on combined antiretroviral treatment had similar level of arterial stiffness to the patients with ST-segment elevation myocardial infarction

“…The importance of WBC (White Blood Cells) count in patients with myocardial infarction has been described in many studies. In patients with STEMI and NSTEMI, the WBC number is important in the first hours of an acute cardiovascular episode as a prognostic marker for patients undergoing primary percutaneous coronary intervention [20,21]. In our study, we observed a statistically significant higher number of WBC in the STEMI group in comparison to HIV-infected patients.…”

Association of Adiponectin With Total Leukocyte Count in Patients of Coronary Artery Disease

“…These results are similar to the observations reported by other studies. [14][15][16][17] Raised total leukocyte count is an indicator of inflammation because it acts as a host defence to injury. In CAD, leukocytes not only cause oxidative and proteolytic injury to the coronary arteries but also aggregate and impact the microvasculature thus leading to hypercoagulable state and electrical instability in the heart.…”

The Role of Natriuretic Peptides in the Regulation of Cardiac Tolerance to Ischemia/Reperfusion and Postinfarction Heart Remodeling

“…74 It is well known that inflammation plays an important role in ischemia/reperfusion injury of the myocardium. 80,81 Therefore, it has been suggested that the cardioprotective effect of BNP during reperfusion may be a consequence of the limitation of leukocyte infiltration in the infarcted area. Indeed, it turned out that after 2 days of cardiac reperfusion, the number of leukocytes in the infarction zone in BNP-treated rats decreased by 30% (Table 2).…”