Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease

Yasuda, Toru; Fukuda-Tani, Momo; Nihira, Tomoko; Wada, Keiichiro; Hattori, Nobutaka; Mizuno, Yoshikuni; Mochizuki, Hideki

doi:10.1016/j.expneurol.2007.05.012

Cited by 54 publications

(41 citation statements)

References 55 publications

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“…An increased level of the vasculogenic and angiogenic protein, vascular endothelial growth factor (VEGF) has been demonstrated in PD patients and in the MPTP model (Yasuda et al, 2007). Likewise, another report provides evidence that nigral injection of VEGF to mice disrupted the BBB permeability and induced dopaminergic neuronal death in the ventral mesencephalon (VM) (Chen et al, 2008a).…”

Section: Blood Brain Barrier Permeabilitymentioning

confidence: 96%

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

Collins¹,

Toulouse²,

Connor³

et al. 2012

Neuropharmacology

258

153

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Section: Blood Brain Barrier Permeabilitymentioning

confidence: 96%

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

Collins¹,

Toulouse²,

Connor³

et al. 2012

Neuropharmacology

258

153

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“…Positron emission tomography (PET) and histological studies on PD patients revealed dysfunction in the BBB transporter system (68) as well as alteration of blood vessels (69) in the midbrain of PD patients. Additionally, the levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) that induce structural changes in blood vessels were increased in PD patients and the MPTP model (70). Interestingly, nigral injection of VEGF disrupted BBB and induced DA neuronal death in the ventral mesencephalon (71).…”

Section: +mentioning

confidence: 99%

The role of neuroinflammation on the pathogenesis of Parkinson's disease

Chung¹,

Ko²,

Bok³

et al. 2010

BMB Reports

141

124

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“…Evidence is accumulating that vascular alterations, in particular angiogenesis, may be a possible mechanism involved in the pathogenesis of PD (Faucheux et al, 1999;Janelidze et al, 2015;Wada et al, 2006;Yasuda et al, 2007). Pericytes are one of the key players in angiogenesis and blood-brain-barrier integrity (Armulik et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Platelet-derived growth factor-BB has neurorestorative effects and modulates the pericyte response in a partial 6-hydroxydopamine lesion mouse model of Parkinson's disease

Padel

Özen

Boix

et al. 2016

Neurobiology of Disease

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Parkinson's disease (PD) is a neurodegenerative disease where the degeneration of the nigrostriatal pathway leads to specific motor deficits. There is an unmet medical need for regenerative treatments that stop or reverse disease progression. Several growth factors have been investigated in clinical trials to restore the dopaminergic nigrostriatal pathway damaged in PD. Platelet-derived growth factor-BB (PDGF-BB), a molecule that recruits pericytes to stabilize microvessels, was recently investigated in a phase-1 clinical trial, showing a dose-dependent increase in dopamine transporter binding in the putamen of PD patients. Interestingly, evidence is accumulating that PD is paralleled by microvascular changes, however, whether PDGF-BB modifies pericytes in PD is not known. Using a pericyte reporter mouse strain, we investigate the functional and restorative effect of PDGF-BB in a partial 6-hydroxydopamine medial forebrain bundle lesion mouse model of PD, and whether this restorative effect is accompanied by changes in pericyte features. We demonstrate that a 2-week treatment with PDGF-BB leads to behavioural recovery using several behavioural tests, and partially restores the nigrostriatal pathway. Interestingly, we find that pericytes are activated in the striatum of PD lesioned mice and that these changes are reversed by PDGF-BB treatment. The modulation of brain pericytes may contribute to the PDGF-BB-induced neurorestorative effects, PDGF-BB allowing for vascular stabilization in PD. Pericytes might be a new cell target of interest for future regenerative therapies.

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Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease

Cited by 54 publications

References 55 publications

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

The role of neuroinflammation on the pathogenesis of Parkinson's disease

Platelet-derived growth factor-BB has neurorestorative effects and modulates the pericyte response in a partial 6-hydroxydopamine lesion mouse model of Parkinson's disease

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