Correlation between Lung and Joint Involvement in Patients with Rheumatoid Arthritis and Interstitial Lung Disease: A Cross-Sectional Study

Paulín, Francisco; Mercado, Juan Francisco; Fernández, Martín Tejedor; Matías, Fabián; Alberti, María Laura; Fassola, Leandro

doi:10.24875/ric.18002474

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…If simple spirometry is used, these patients cannot be identified. In our work those patients with lung disease presented higher rates of inflammatory serological markers, such as ESR and CRP, in line with previous studies [14][15][16][17] . In our study, higher values of CRP and ESR at RA diagnosis associated a DLCO decrease over time.…”

Section: Discussionsupporting

confidence: 92%

“…In our study, higher values of CRP and ESR at RA diagnosis associated a DLCO decrease over time. The presence of inflammatory proteins in the lungs has been associated with progressive lung disease 16 and higher rates of ESR associate ground glass opacities on lung HRCT 15 . Sparks et al reported a higher risk for the development of RA-ILD in patients with higher values of DAS28 in a prospective cohort of RA patients 8 .…”

Section: Discussionmentioning

confidence: 99%

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A prospective study of lung disease in a cohort of early rheumatoid arthritis patients

Robles-Pérez

Luburich

Bolivar

et al. 2020

Sci Rep

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Lung disease is common in patients with rheumatoid arthritis (RA). The onset of lung involvement in RA is not well known. The objective is to describe the features and evolution of lung involvement in early RA, its relationship with disease activity parameters, smoking and treatments. Consecutive patients with early RA without respiratory symptoms were included and tracked for 5 years. Lung assessment included clinical, radiological and pulmonary function tests at diagnosis and during follow-up. Peripheral blood parameters (erythrocyte sedimentation rate, C reactive protein, rheumatoid factor and anti-citrullinated peptide autoantibodies) and scales of articular involvement, such as DAS28-CRP, were evaluated. 40 patients were included and 32 completed the 5-year follow up. 13 patients presented lung involvement in the initial 5 years after RA diagnosis, 3 of them interstitial lung disease. Significant decrease of diffusion lung transfer capacity of carbon monoxide over time was observed in six patients, 2 of them developed interstitial lung disease. DLCO decrease was correlated with higher values of CRP and ESR at diagnosis. Methotrexate was not associated with DLCO deterioration or lung disease development. Subclinical progressive lung disease correlates with RA activity parameters. Smoking status and methotrexate were not associated with development or progression of lung disease.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

A prospective study of lung disease in a cohort of early rheumatoid arthritis patients

Robles-Pérez

Luburich

Bolivar

et al. 2020

Sci Rep

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“…Females with rheumatoid arthritis older than 60 years of age were found to be associated with significantly higher prevalence of gall stones compared with general population and the most probable reason is hyperlipidemia and chronic inflammation. 13 The other co-morbidities with cholelithiasis include Crohn's disease, ileal resection or other diseases of ilium, hence it is important to know the frequency of gall bladder diseases which might provide the clue about comorbidities as well.…”

Section: Introductionmentioning

confidence: 99%

Morphological Spectrum of Gall Bladder Diseases at A Tertiary Care Hospital of Karachi

Shabbir¹,

Irshad²,

Javed³

et al. 2020

Ann Jinnah Sindh Med Uni

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Objectives: To determine morphological spectrum of gall bladder diseases at a tertiary care centre of Karachi and to correlate with age and gender. Methodology: Data was collected from histopathological records between June 2017 to June 2019. Relevant data including registration number, age, gender of the patients and diagnosis were recorded. Data was entered and analyzed using SPSS version 21. P-value < 0.05 was considered as significant. Results: In our study, patients 26-35 years of age were predominantly found to be susceptible to gall bladder diseases and male to female ratio was 1:3.7. Out of the total 150 cases, 75 were identified as chronic cholecystitis with cholelithiasis whereas 32 cases of chronic cholecystitis were without stones or any other associated pathology. Out of 150 cases, 40 were seen in combination with different pathologies. Our series also included three cases of adenocarcinoma and all of these were diagnosed in females. Significant association of diagnosis was seen with gender and type of stones (p-value = 0.03) (p-value = 0.01) respectively. Conclusion: In our study, chronic cholecystitis with cholelithiasis was the most common finding which was most predominantly seen in females. Younger age group was mainly affected in both genders. Mixed type of gall stones were the most common stones found in our series.

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“…A previous study investigating joint and lung involvement in patients with RA-ILD reported a good correlation between the ESR and the ground glass score of HRCT images of the lungs. 20 …”

Section: Discussionmentioning

confidence: 99%

Protective effect of methotrexate on lung function and mortality in rheumatoid arthritis–related interstitial lung disease: a retrospective cohort study

Kim

Woo

Park

et al. 2022

Ther Adv Respir Dis

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Background: Studies on the risk and protective factors for lung function decline and mortality in rheumatoid arthritis–related interstitial lung disease (RA-ILD) are limited. Objectives: We aimed to investigate clinical factors and medication uses associated with lung function decline and mortality in RA-ILD. Methods: This retrospective cohort study examined the medical records of patients with RA-ILD who visited Severance Hospital between January 2006 and December 2019. We selected 170 patients with RA-ILD who had undergone at least one spirometry test and chest computed tomography scan. An absolute decline of ⩾10% in the functional vital capacity (FVC) was defined as significant decline in pulmonary function. Data for analysis were retrieved from electronic medical records. Results: Ninety patients (52.9%) were female; the mean age was 64.0 ± 10.2 years. Multivariate logistic regression showed that a high erythrocyte sediment rate level at baseline [odds ratio (OR) = 3.056; 95% confidence interval (CI) = 1.183–7.890] and methotrexate (MTX) use (OR = 0.269; 95% CI = 0.094–0.769) were risk and protective factors for lung function decline, respectively. Multivariate Cox regression analysis indicated that age ⩾65 years (OR = 2.723; 95% CI = 1.142–6.491), radiologic pattern of usual interstitial pneumonia (UIP) or probable UIP (OR = 3.948; 95% CI = 1.522–10.242), baseline functional vital capacity (FVC) % predicted (OR = 0.971; 95% CI = 0.948–0.994), and MTX use (OR = 0.284; 95% CI = 0.091–0.880) were predictive of mortality. Conclusion: We identified risk and protective factors for lung function decline and mortality in patients with RA-ILD. MTX use was associated with favorable outcome in terms of both lung function and mortality in our cohort.

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Correlation between Lung and Joint Involvement in Patients with Rheumatoid Arthritis and Interstitial Lung Disease: A Cross-Sectional Study

Abstract: We only found a good correlation between ESR and ground glass score. It is possible that different pathways of the immune response mediate damage in lungs and joints.

Cited by 6 publications

References 31 publications

A prospective study of lung disease in a cohort of early rheumatoid arthritis patients

A prospective study of lung disease in a cohort of early rheumatoid arthritis patients

Morphological Spectrum of Gall Bladder Diseases at A Tertiary Care Hospital of Karachi

Protective effect of methotrexate on lung function and mortality in rheumatoid arthritis–related interstitial lung disease: a retrospective cohort study

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