Correlation between Lymphocyte-to-Monocyte Ratio (LMR), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR) and Extramural Vascular Invasion (EMVI) in Locally Advanced Rectal Cancer

Abstract

Rectal cancer constitutes around one-third of all colorectal cancers. New markers are required to optimize the treatment. Extramural vascular invasion (EMVI) is a magnetic resonance imaging (MRI)-based negative prognostic marker. Lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR) are blood-based systemic inflammatory response markers with proven prognostic value in many cancers, including CRC. We hypothesized whether there is a relationship between LMR, NLR, PLR and the presence of EMVI on pre-treatment MRI in patients with locally advanced rectal cancer (LARC). We conducted a retrospective analysis of 371 patients with LARC treated in the Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland between August 2016 and December 2021. One hundred eighty-four patients were found eligible for the study. A correlation between the extension of the tumour, nodal status, clinical stage of the disease and the presence of EMVI was found (p < 0.001). The pre-treatment level of neutrophils, platelets and carcinoembryonic antigen (CEA) was significantly higher in the EMVI-positive population (p = 0.041, p = 0.01, p = 0.027, respectively). There were no significant differences regarding the level of LMR, NLR and PLR between the EMVI-positive and EMVI-negative population. LMR, NLR and PLR do not differentiate patients in terms of EMVI; neither of these parameters is a good predictor of the status of EMVI in LARC.

A Prospective Study on the Roles of the Lymphocyte-to-Monocyte Ratio (LMR), Neutrophil-to-Lymphocyte Ratio (NLR), and Platelet-to-Lymphocyte Ratio (PLR) in Patients with Locally Advanced Rectal Cancer

“…In other malignancies, the data on correlations between SIR markers and PD-L1 expression are conflicting [27,28]. We found no association between the SIR markers and the level of CEA, which corresponded to a retrospective study on rectal cancer patients [29]. The PD-L1 expression in the immune cells was positively correlated with both the inflammatory infiltrates and the tumor-infiltrating CD8 lymphocytes.…”

Peripheral blood immune cell parameters in patients with high-grade squamous intraepithelial lesion (HSIL) and cervical cancer and their clinical value: a retrospective study

“…Comparisons with previous studies ( Prabawa et al, 2019 ; Gawiński, Hołdakowska & Wyrwicz, 2022 ; Ozmen et al, 2017 ) underscore the utility of PLR and NLR as non-invasive biomarkers for assessing disease severity, guiding treatment decisions, and predicting outcomes in cervical cancer. The establishment of these correlations further strengthens the potential clinical value of PLR and NLR in aiding risk stratification, treatment selection, and patient prognostication.…”

A Nomogram Model Based on the Inflammation-Immunity-Nutrition Score (IINS) and Classic Clinical Indicators for Predicting Prognosis in Extranodal Natural Killer/T-Cell Lymphoma

“…9,10 A growing number of studies have illustrated the diagnostic and prognostic values of inflammatory markers, such as LMR, NLR, systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI), in various cancers. [26][27][28][29] Recently, a study found that the Glasgow Prognostic Score (GPS), an inflammation-based prognostic evaluation system comprising measures of C-reactive protein and albumin, showed significant prognostic value in ENKTL. 30 However, the prognostic system is The results showed that the CONUT score was more efficient in predicting ENKTL prognosis than the IPI, KPI and PINK models.…”