Correlation Between Maternal and Neonatal Vitamin B12 Serum Levels in Full Term Neonates with Physiologic Jaundice

Aziz, Reem A. Abdel; Elela, Mostafa Ahmed Abu

doi:10.15344/2455-2364/2018/137

Cited by 2 publications

(7 citation statements)

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“…Aziz and Elela demonstrated that the vitamin B12 level of newborns with jaundice was significantly lower than healthy controls. 9 Maternal vitamin B12 is positively correlated with neonatal vitamin B12 and negatively correlated with neonatal total serum bilirubin levels. 9 In the present study, serum vitamin B12 levels in infants with prolonged jaundice and undetermined etiology were significantly lower in the study group.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

“…9 Maternal vitamin B12 is positively correlated with neonatal vitamin B12 and negatively correlated with neonatal total serum bilirubin levels. 9…”

Section: Discussionmentioning

confidence: 97%

“…As a result of this ineffective erythropoiesis, jaundice develops with increased plasma bilirubin level. 9 In the literature, there are no studies showing correlations between vitamin B12 deficiency with other causes blamed for breast milk jaundice such as β-glucuronidase, free fatty acids, pregnan-3a, and genetic causes. 3 Vitamin B12 deficiency causes much more significant neurological symptoms in infants who have rapid growth like in the newborn period, but anemia-associated findings are more common in other periods.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, lysis of erythrocytes elevates plasma bilirubin levels that can end in jaundice in newborns. 9 Depending on this fact, vitamin B12 deficiency can be considered one of the implicit reasons for prolonged jaundice. Therefore, this study aimed to evaluate the association between vitamin B12 deficiency and prolonged jaundice of newborns.…”

Section: Introductionmentioning

confidence: 99%

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An Implicit Cause of Prolonged Neonatal Jaundice: Vitamin B12 Deficiency

Aygün

Sayman

Ertürk

et al. 2023

Journal of Child Science

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Objective Prolonged jaundice is defined as a serum bilirubin level of more than 5 mg/dL, which persists at postnatal 14 days in term infants and 21 days following birth in preterm infants. Although the underlying causes cannot be found in the majority of prolonged jaundice cases, this may be the first sign of a serious issue. Therefore, this study aimed to evaluate the association between vitamin B12 deficiency and prolonged jaundice in newborns. Material and Methods This descriptive cross-sectional study was performed in a university hospital between January 1, 2015 and October 1, 2020. All participants consisted of infants who were admitted to the pediatric outpatient clinics. Infants > 35 weeks of gestation and with prolonged jaundice of unknown etiology were included in the study group. The control group consisted of infants > 35 weeks of gestation without prolonged jaundice. Demographic and clinical characteristics and serum vitamin B12 levels were evaluated comparatively. Results A total of 126 infants, 66 of whom had prolonged jaundice, were included. The mean gestational week of the study group was 38.4 ± 1.8, and the control group was 38.6 ± 1.9 weeks. There was no difference between the groups in terms of demographics and laboratory data. The vitamin B12 level of the study group was significantly lower (median = 170 pg/mL) than the control (median = 268 pg/mL). Conclusion Based on the findings of this study, vitamin B12 deficiency was thought to be an important cause of prolonged jaundice, and further studies are needed to explain the role of vitamin B12 deficiency in the etiology of prolonged jaundice.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

“…9 Maternal vitamin B12 is positively correlated with neonatal vitamin B12 and negatively correlated with neonatal total serum bilirubin levels. 9…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An Implicit Cause of Prolonged Neonatal Jaundice: Vitamin B12 Deficiency

Aygün

Sayman

Ertürk

et al. 2023

Journal of Child Science

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2023

Journal of Child Science

View full text Add to dashboard Cite

Objective Prolonged jaundice is defined as a serum bilirubin level of more than 5 mg/dL, which persists at postnatal 14 days in term infants and 21 days following birth in preterm infants. Although the underlying causes cannot be found in the majority of prolonged jaundice cases, this may be the first sign of a serious issue. Therefore, this study aimed to evaluate the association between vitamin B12 deficiency and prolonged jaundice in newborns. Material and MethodsThis descriptive cross-sectional study was performed in a university hospital between January 1, 2015 and October 1, 2020. All participants consisted of infants who were admitted to the pediatric outpatient clinics. Infants > 35 weeks of gestation and with prolonged jaundice of unknown etiology were included in the study group. The control group consisted of infants > 35 weeks of gestation without prolonged jaundice. Demographic and clinical characteristics and serum vitamin B12 levels were evaluated comparatively. Results A total of 126 infants, 66 of whom had prolonged jaundice, were included. The mean gestational week of the study group was 38.4 AE 1.8, and the control group was 38.6 AE 1.9 weeks. There was no difference between the groups in terms of demographics and laboratory data. The vitamin B12 level of the study group was significantly lower (median ¼ 170 pg/mL) than the control (median ¼ 268 pg/mL). Conclusion Based on the findings of this study, vitamin B12 deficiency was thought to be an important cause of prolonged jaundice, and further studies are needed to explain the role of vitamin B12 deficiency in the etiology of prolonged jaundice.

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Correlation Between Maternal and Neonatal Vitamin B12 Serum Levels in Full Term Neonates with Physiologic Jaundice

Cited by 2 publications

References 10 publications

An Implicit Cause of Prolonged Neonatal Jaundice: Vitamin B12 Deficiency

An Implicit Cause of Prolonged Neonatal Jaundice: Vitamin B12 Deficiency

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