Correlation between maternal and neonatal blood Vitamin D level: Study from Pakistan

Rabbani, Shahida N.; Afaq, Saima; Fazid, Sheraz; Khattak, Maria Ishaq; Yousafzai, Yasir Mehmood; Habib, Syed Hamid; Lowe, Nicky; Haq, Zia Ul

doi:10.1111/mcn.13028

Cited by 20 publications

(27 citation statements)

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“…In the study done by Rabbani et al they evaluated the Correlation between maternal and neonatal blood VD level among 213 pregnant women and their neonates and their results showed strong positive association between maternal and newborn 25(OH)D levels (p < 0.001) [19].…”

Section: Discussionmentioning

confidence: 99%

Impact of Maternal and Neonatal Vitamin D Status on the Development of Congenital Anomalies in Egyptian Model

Mohamed

Barbary

Ahmed

et al. 2022

Open Access Maced J Med Sci

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Background: Vitamin D (VD) is a remarkable problem during pregnancy. VD plays a crucial role in cellular growth and differentiation during embryogenesis. VD deficiency in pregnancy is associated with various maternal and neonatal comorbidities. Aim: In this study, we aimed to evaluate the potential association between maternal and neonatal vitamin D status and the subsequent development of congenital anomalies. Patients and methods: A case-control study involving 30 mothers and their neonates born with gross structural congenital anomalies as cases and 30 mothers and their healthy neonates as controls recruited from Ain Shams University Children Hospital. Maternal and Neonatal blood samples were obtained to determine serum 25-hydroxyvitamin D. The 25-hydroxyvitamin D concentration was stratified into a severe deficient<10ng/ml, deficient <20ng/ml, insufficient 20-29ng/ml and sufficient >30ng/ml. Status above 150ng/ml presents high risk of toxicity. Results: There were statistically significant differences between the two groups regarding maternal and neonatal vitamin D serum level within 29 days postpartum. Mean maternal vitamin D level in cases was 23.8ng/ml versus 42.13ng/ml in controls (P = 0,000). Mean neonatal vitamin D level in cases was 15.97ng/ml versus 28.9ng/ml in controls (P = 0,000).There was significant positive correlation between both maternal and neonatal vitamin D level with birth weight. Conclusion: A compromised maternal vitamin D status is associated with an increased prevalence of congenital anomalies in offspring. Therefore, improvement of the periconceptional maternal vitamin D status is recommended.

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Section: Discussionmentioning

confidence: 99%

Impact of Maternal and Neonatal Vitamin D Status on the Development of Congenital Anomalies in Egyptian Model

Mohamed

Barbary

Ahmed

et al. 2022

Open Access Maced J Med Sci

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“…Vitamin D deficiency is more prevalent in children, pregnant and nursing women in Pakistan [ 9 ], India [ 10 ], and Germany [ 11 ]. A study reported from Karachi, vitamin D deficiency in 75% of children associated with low socioeconomic communities [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Adjunctive vitamin D therapy in various diseases in children: a scenario according to standard guideline

et al. 2022

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Background Adherence to standard guidelines is imperative when question comes to disease management. The present study aimed to evaluate the administration of adjunctive vitamin D therapy in various diseases, its adherence to standard guideline and the effect of socioeconomic status on the consumption of vitamin D in children. Methods Cross sectional observational study was conducted among 400 ambulatory pediatric patients at Children’s Hospital, Pakistan Institute of Medical Sciences Islamabad, from November 2017 to June 2018. Data were collected by a self-designed structured questionnaire from the patient’s medical chart. Adjunctive vitamin D therapy adherence was evaluated by the U. S endocrinology clinical practice guideline of vitamin D deficiency. The association between socioeconomic status and consumption of vitamin D was examined by chi-square. Alpha value (p ≤ 0.005) was considered statistically significant. Statistical analysis was done by SPSS version 25. Results In 400 patients, 9 diseases and 21 comorbid conditions were identified, in which adjunctive vitamin D therapy was prescribed. Adherence to vitamin D testing in high-risk vitamin D deficiency diseases as; seizures (3.8%), bone deformities (13.3%), steroid-resistant nephrotic syndrome (0.0%), cerebral palsy (5.9%) and meningitis (14.3%). Adherence to prescribed vitamin D dose was in (41.3%) patients in various diseases. Significant association (p < 0.05) was found between socioeconomic status and consumption of vitamin D in children and mothers. Conclusions It was found that adjunctive vitamin D was being prescribed in various diseases and comorbidities. Overall poor adherence to the standard guideline was observed in disease management in children. Low socioeconomic status affects vitamin D supplementation consumption in children.

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“…Infants with nutritional rickets often present at early stage when exclusive or partial breastfeeding is predominant (12). Studies showed that the concentration of serum 25(OH)D in mothers was positively correlated with that in cord blood of newborns (13,14), but the correlation between mothers and infants was unclear. It was reported that vitamin D levels in the human breast milk were positively related to maternal serum concentrations of vitamin D (15).…”

Section: Introductionmentioning

confidence: 99%

Serum vitamin D levels in lactating mothers and their exclusive breastfeeding infants with symptoms of rickets

Song

Liu

et al. 2022

Preprint

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Objective To evaluate the vitamin D status in postpartum women during lactation and their exclusively breastfed infants with symptoms of rickets at 4–6 weeks after birth. Factors associated with breastfed infant serum vitamin D status were also determined. Methods One hundred and two exclusively breastfeeding infants with symptoms of nutritional rickets and their mothers were recruited in this study. Sociodemographic and clinical data including blood samples were collected during their visit to the children healthcare counseling clinic. Lactating mothers and their nursing infants were classified into sufficient, insufficient, and deficient according to serum 25(OH)D levels. Multivariate logistical regression model was used to analyses the final adjusted odds ratio and 95% CI. Results The prevalence of vitamin D sufficiency in lactating mother and exclusively breastfed infants were 8.7% and 40.2%, respectively. Final multiple logistic regression showed that infant daily vitamin D intake and body weight were statistically significantly associated with vitamin D status. Infant who had a vitamin D intake of > 400 IU per day (adjusted OR, 3.47; 95%CI, 1.06–11.30) was more likely to be vitamin D sufficiency. Infant with a higher body weight was associated with vitamin D sufficient status (adjusted OR, 2.01; 95%CI, 1.11–3.66). Conclusions Our study shows a very low prevalence of 25(OH)D sufficiency in lactating mothers, and a moderate vitamin D sufficiency in the exclusive breastfeeding infants with symptoms of rickets. Infant daily vitamin D intake and body weight were related to their vitamin D status. Findings of this study indicate the importance of vitamin D supplementation to maintain sufficient 25(OH)D levels in infants.

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Correlation between maternal and neonatal blood Vitamin D level: Study from Pakistan

Cited by 20 publications

References 48 publications

Impact of Maternal and Neonatal Vitamin D Status on the Development of Congenital Anomalies in Egyptian Model

Impact of Maternal and Neonatal Vitamin D Status on the Development of Congenital Anomalies in Egyptian Model

Adjunctive vitamin D therapy in various diseases in children: a scenario according to standard guideline

Serum vitamin D levels in lactating mothers and their exclusive breastfeeding infants with symptoms of rickets

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