Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients

Abstract

Background: Our objective was to associate serum levels of myocardial enzymes and infl ammatory biomarkers with severity of coronary artery disease (CAD). Patients and methods: 123 patients participated in our study, including 65 cases of acute myocardial infarction (MI), 27 cases of newly diagnosed CAD -without MI -and 31 controls. In all subjects, myocardial serum enzyme levels (creatine phosphokinase, aspartate aminotransferase, lactate dehydrogenase) and infl ammatory indices (C-reactive protein, fi brinogen, white blood cells, and erythrocyte sedimentation rate) were measured. Patients were all submitted to coronary angiography and CAD severity was evaluated by Gensini score. Results: Signifi cant differences concerning enzyme serum levels and infl ammatory indices were found to exist between the three study groups, being highest among patients with acute MI (p Ͻ 0.001). A signifi cant association was demonstrated between Gensini score and serum enzyme levels as well as infl ammatory biomarkers. Conclusions: Our fi ndings suggest that serum levels of myocardial enzymes and infl ammatory indices correlate with CAD severity in Greek patients.

Circulating CD14⁺CD16⁺ Monocyte Subsets as Biomarkers of the Severity of Coronary Artery Disease in Patients With Stable Angina Pectoris

“…Patients with MVD presented a higher Gensini score among the 3 groups (non-CAD, 6.0 (Figure 2A). Although no significant differences were seen among the 3 groups in terms of peripheral total monocyte counts, CD14 + CD16 + monocyte counts were significantly higher in patients with MVD (84 [58-120] cells/μl) than in those with SVD (vs. 47 cells/μl, P<0.001) or without CAD (vs. 28 [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] cells/μl, P<0.001) (Figure 2B). However, CD14 + CD16 − monocyte counts were not significantly different among the 3 groups.…”

Comparative Study of Potential Diagnostic Biomarkers in Myocardial Infarction with Survival and Myocardial Infarction without Survival

“…23 In the current study, serum levels of LDH and AST were significantly increased in MI. Peppes et al 24 have…”

Effect of Implementing Clinical Pathway Guidelines on Patients&apos; Clinical Outcomes with Acute Coronary Syndrome

“…In this regard Peppes et al (2008) [31] stated that cardiac troponin is the gold standard in the diagnosis of acute coronary syndrome and is measured in all patients with symptoms suggestive of acute coronary syndrome, in conjunction with physical examination and ECG. On the other hand, Antman (2008) [29] and Apple (2010) [32] reported that some patients with myocardial infarction in his study did not have elevated troponins or CK values and they may die before the cardiac markers reach the threshold.…”