Correlation between nasal eosinophils and nasal airflows in children with asthma and/or rhinitis monosensitised to house dust mites

Yükselen, Ayfer; Kendirli, Seval Güneşer; Yılmaz, Mustafa; Altıntaş, Derya Ufuk; Karakoç, Gülbin Bingöl

doi:10.1016/j.aller.2012.07.001

Cited by 4 publications

(8 citation statements)

References 21 publications

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“…A 2012 study of 37 pediatric patients with AR by Yukselen et al found a significantly higher nasal eosinophil count in patients with AR and coexisting asthma compared to patients with AR alone. 11 Canbaz et al, in a study of 37 patients with persistent AR, found a lower nasal airflow and a higher nasal eosinophil count in those with coexistent bronchial hyper-responsiveness. 19 According to the article, a cutoff point of 68% nasal eosinophils yielded a sensitivity of 100% (63.1 to 100) and a specificity of 58.6% (38.9 to 76.5) to determine the presence of bronchial hyper-responsiveness.…”

Section: Discussionmentioning

confidence: 92%

Nasal Smear Eosinophils and Allergic Rhinitis

et al. 2017

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Our aim was to find out the association between nasal smear eosinophil count and allergic rhinitis (AR) and to determine a cutoff value that is significant for a diagnosis of AR. We also wanted to determine whether this count is related to the predominant symptoms, duration, or type and severity of AR, or to the presence of coexisting asthma. We selected 100 patients with a clinical diagnosis of allergic rhinitis across all age groups and an equal number of age-and sex-matched controls for the study. Their nasal smear eosinophil counts were recorded in terms of the number of eosinophils per high-power field (HPF). All patients were then clinically assessed for asthma and underwent spirometry. The data were recorded and appropriate statistical analysis done. The difference in the mean eosinophil counts of patients with AR and controls was found to be statistically significant (p = 0.000). A nasal smear eosinophil count of >0.3 per HPF had a 100% specificity and a 100% positive predictive value for AR. Asthma was associated with allergic rhinitis in 40% of patients; an association was not found between nasal smear eosinophil count and the symptoms, duration, type, and severity of allergic rhinitis or coexistent asthma. We conclude that an eosinophil count of >0.3 per HPF in nasal smears is a highly specific criterion for the diagnosis of AR. However, nasal smear eosinophil counts are poor indicators of the degree, duration, or type of upper or associated lower airway inflammation due to allergy.

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Section: Discussionmentioning

confidence: 92%

Nasal Smear Eosinophils and Allergic Rhinitis

et al. 2017

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“…Although this fact is expected, there are some contradictions in the available publications about the significance of TNAF in children with BA. So, Yukselen et al [ 20 ] observed the average degree of nasal obstruction in children with asthma with TNAF = 328±177 cm 3 /s. It should be noted that the causes of nasal obstruction were not elucidated in their study and the children's age was from 6 to 15 years.…”

Section: Discussionmentioning

confidence: 99%

“…Motomura et al [ 19 ] demonstrated that, for patients with asthma, a decrease in nasal airflow is characteristic, but the effect of the comorbid UAP on the respiratory function of the nose was not considered. Yukselen A. et al [ 20 ] established a significant relationship between spirometric parameters and nasal airflow in children with asthma. However, the effect of NOD on the respiratory function of the nose in this study was also not taken into account [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Dependence of Anterior Active Rhinomanometry Indices on Nasal Obstructive Disorders in Children with Atopic Bronchial Asthma Complicated by Nasal Symptoms

Eliseeva

Krasilnikova

Babaev

et al. 2018

BioMed Research International

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Background Atopic bronchial asthma (BA) in children is associated with upper airways pathology (UAP). Among them, a combination of allergic rhinitis (AR) and nasal obstructive disorders (NOD), including hypertrophy of the pharyngeal tonsil (HPT) and anomalies of the intranasal structures (AINS), is abundant. In such patients, anterior active rhinomanometry (AARM) is an important method of examining nasal patency. However, NOD can influence the AARM parameters in children with BA and nasal symptoms, and this effect must be taken into account in clinical practice. Study goal was to elucidate the effect of NOD on rhinomanometric parameters in this group of patients. MethodsTotal of 66 children with BA and AR were examined with AARM, rhinovideoendoscopy, spirometry, and standard clinical tests allowing revealing the structure of comorbid pathologies. In order to avoid the influence of anthropometric parameters of children and their age on AARM parameters, a special index of reduced total nasal airflow was used. ResultsIt has been established that NOD, especially HPT, have a significant negative impact on the indices of anterior active rhinomanometry during the periods of both AR remission and AR exacerbation. The effect of AINS is much weaker and was remarkable only in combination with HPT.

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“…Um die Dringlichkeit der Maßnahme abzuschätzen und die Effizienz des diagnostischen Vorgehens zu erhöhen kann vor weiterführender Lungenfunktionsdiagnostik ein Asthmafragebogen ausgefüllt werden [23]. Alternativ kann die Notwendigkeit der Lungenfunktionsdiagnostik auch anhand des Peak Nasal Inspiratory Flow (PNIF) abgeschätzt werden, da dieser mit der Einsekundenkapazität (FEV1) bei Patienten mit einer Rhinitis korreliert [60].…”

Section: Lungenuntersuchungunclassified

Nicht-allergische Rhinitis: Epidemiologie, Diagnostik und Therapie

Lorenz

Küster²,

Beule³

2015

Laryngo-Rhino-Otol

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Non-allergic rhinitis is a heterogenous group of medical diseases without an IgE-mediated pathophysiology. In this review, typical subgroups are presented with data regarding their frequency, clinical symptoms and recommendations for an effective and efficient diagnostic and therapeutic approach are indicated. The most common subtype is the non-allergic rhinopathy, also known as idiopathic or vasomotoric rhinitis. Because medication induced rhinitis is still a frequent clinical problem, a step wise approach to wean the patient is presented.

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Correlation between nasal eosinophils and nasal airflows in children with asthma and/or rhinitis monosensitised to house dust mites

Cited by 4 publications

References 21 publications

Nasal Smear Eosinophils and Allergic Rhinitis

Nasal Smear Eosinophils and Allergic Rhinitis

Dependence of Anterior Active Rhinomanometry Indices on Nasal Obstructive Disorders in Children with Atopic Bronchial Asthma Complicated by Nasal Symptoms

Nicht-allergische Rhinitis: Epidemiologie, Diagnostik und Therapie

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