Correlation between Nerve Growth Factor (NGF) with Brain Derived Neurotropic Factor (BDNF) in Ischemic Stroke Patient

Abstract

Background: The neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) is a family of polypeptides that play critical role during neuronal development, appear to mediate protective role on neurorepair in ischemic stroke. Naturally in adult brain neurorepair process consist of: angiogenesis, neurogenesis, and neuronal plasticity, it can also be stimulated by endogenous neurorepair. In this study we observed correlation between NGF and BDNF ischemic stroke patient's onset: 7-30 and over 30 days. Methods: This is cross sectional study on 46 subjects aged 38 -74 years old with ischemic stroke from The Indonesian Central Hospital of Army Gatot Subroto Jakarta. Diagnosis of ischemic stroke was made using clinical examination and magnetic resonance imaging (MRI) by neurologist. Subjects were divided into 2 groups based on stroke onset: 7 -30 days (Group A: 19 subjects) and > 30 days (Group B: 27 Subjects). Serum NGF levels were measured with ELISA method and BDNF levels were measured using multiplex method with Luminex Magpix. Results: Levels of NGF and BDNF were significantly different between onset group A and B (NGF p= 0.022, and BDNF p=0.008), with mean levels NGF in group A higher than group B, indicating that BDNF levels is lower in group A than group B. There was no significant correlation between NGF and BDNF levels in all groups. Conclusion:The variations in neurotrophic factor levels reflect an endogenous attempt at neuroprotection against biochemical and molecular changes after ischemic stroke. NGF represents an early marker of brain injury while BDNF recovery is most prominent during the first 14 days after onsite but continuous for more than 30 days. There is no significant correlation between NGF and BDNF in each group.

Circulating Brain-Derived Neurotrophic Factor as a potential biomarker in stroke: a Systematic review and Meta-analysis

“…Finally, a total number of 62 articles were entered into our systematic review. We could not enter 16 articles to any meta-analysis group due to the following reasons; providing delta BDNF instead of exact measures (33), reporting BDNF as a proportion to the control group (34), full text was not found, although the abstract was su cient to extract the descriptive data (35), unsatisfactory data and irresponsive author (missing SD) (36), single study group with no comparison or speci c grouping which did not fall into our meta-analysis categorizations (37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48).…”

Нейропластичность И Постинсультные Когнитивные Нарушения (Терапевтические Возможности)

“…Активация NGF индуцирует антиапоптотические механизмы после инсульта, повышает устойчивость нейронов к воздействию оксидативного стресса, уменьшает размер инфаркта и вторичную гибель нервных клеток [78,83,88,89], стимулирует регенерацию нейронов, ускоряет синаптогенез и повышает плотность нейронных связей, увеличивает арборизацию дендритов и аксональный спраутинг [68,73,83,89]. Отмечено, что спраутинг и арборизация продолжаются в разные восстановительные периоды после инсульта, однако наиболее активны эти процессы в течение первого месяца [90,91].…”

Increased Levels of Nerve Growth Factor Indicating Brain Injury In Mice Model

“…The NGF protein increases from the first week and persists for 7 weeks (Cheng et al, 2016). NGF has been used only in several case report in developed country, there is lack of reports and studies in Indonesia regarding (NGF) in brain injury.This agent has been used for hypoxicischemic injury and showed a favorable outcome, but the result is still vary (Fantacci et al, 2013;Widodo et al, 2016).…”