Correlation between normal glucose-6-phosphate dehydrogenase level and haematological parameters

Ajlaan, Salman K.; Al-Naama, Lamia M.; Al-Naama, Menhel M.

doi:10.26719/2000.6.2-3.391

Cited by 5 publications

(2 citation statements)

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“…It is thus concluded that qualitative tests and hospital studies very poorly demonstrate the actual position of this serious threat because mainly diseased people visit hospitals and they do not represent the whole population for prevalence, thus detailed investigations in various ethnic groups at a larger level must be carried out. In Asian countries, its prevalence has been reported in Indonesia, Thailand, Malaysia, Bangladesh, [20][21][26][27][28][29][30] Pakistan and China.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Mediterranean Mutation of Glucose 6 Phosphate Dehydrogenase in Children of Malak Din Khel Subtribe of Afridi

Amjid,

Farooq

2023

L&S

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Objective: To determine the prevalence of Glucose 6 Phosphate Dehydrogenase (G6PD) deficiency in the Malak Din Khel subtribe, the biggest subtribe of Afridi, with expectations of newer findings in the area of medicine and research.Study Design: Cross-sectional study.Place and Duration of Study: This study was conducted in District Khyber from March 2018 to August 2018.Materials and Methods: The sample size of this study was 177 preschool-going children of 4-5 years of age. Multistage cluster sampling was done. Only resident families of Khyber Agency were selected. Children of age 04 to 05 years were enrolled in the study after consent from a parent/ guardian. Children with major comorbidities, non-consenting parents/ guardians, and children transfused in the last 24-48 hours were excluded from the study. 05 ml of blood was collected from each child. G6PD qualitative tests were performed in the field; rest of the tests were carried out later at Dabgari Garden “”in lab. PCR was processed according to protocol. Data were analyzed by SPSS 26.0.Results: A total sample size of 177 respondents were initially investigated through a qualitative test for G6PD deficiency. Among these, only 4 (2.3%) respondents were found to be G6PD deficient, The PCR analysis depicted that among 177 respondents, 31 (17.5%) were found to be mutant. Among these, 26(84%) were heterozygous, while 5 (16%) respondents were found to be homozygous. The PCR analysis further revealed that among the 5 homozygous respondents, 3 were found to be G6PD deficient, as also depicted by the qualitative test. One of the homozygous respondents, although found deficient by qualitative test, showed no Mediterranean mutation.Conclusion: Most studies done in Pakistan are hospital-based and the method for diagnosing is a qualitative test, but if the G6PD enzyme activity level is more than 30% qualitative test cannot pick the respondent as deficient. In our study, we ran qualitative tests on all respondents and only 4/177(2.3%), followed by PCR analysis for Mediterranean mutation of all samples, which showed that 31/177 (17.5%) were G6PD deficient. Further studies need to be conducted in the same manner to know the exact prevalence of G6PD. Detailed studies in other ethnic groups of the country must also be conducted to highlight the actual position of this threat.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Mediterranean Mutation of Glucose 6 Phosphate Dehydrogenase in Children of Malak Din Khel Subtribe of Afridi

Amjid,

Farooq

2023

L&S

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“…We do not have genotype information available for the majority of our patients in this study, which may provide a better predictor of risk of hemolysis than a single measurement of G6PD activity. 9 As G6PD levels can be elevated in the setting of reticulocytosis 10 and/or elevated leukocyte counts, 11 further correlation with genotype and G6PD assay level may provide important clinical insights to predict the risk of clinically significant hemolysis. Indeed, 3 patients with anemia in this study were not re-tested at a later date within our institution and so their levels may have been artificially elevated.…”

Section: Discussionmentioning

confidence: 99%

Hemolysis After Medication Exposure in Pediatric Patients With G6PD Deficiency

Doshi

Kamdar

Lambert

et al. 2021

Journal of Pediatric Hematology/Oncology

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Hemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficiency varies by mutation status and the oxidative stressor. Although classified by percent of enzymatic deficiency, variability in normal G6PD values clouds assessment of hemolysis risk by level. This was a retrospective, single institution, cohort study assessing risk of postexposure medication-induced hemolysis in G6PD deficient patients. Exposures occurred in 87 of 1415 deficient patients. Only 2 of 87 medication-exposed patients had hemolytic episodes and both had very low enzymatic activity. No hemolytic events occurred with G6PD levels > 7 units/g hemoglobin. Correlation of levels with mutation may improve predictive capacity for hemolysis in G6PD deficiency.

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Prevalence of G6PD deficiency and associated haematological parameters in children from Botswana

Motshoge

Ababio

Aleksenko

et al. 2018

Infection, Genetics and Evolution

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Correlation between normal glucose-6-phosphate dehydrogenase level and haematological parameters

Cited by 5 publications

References 0 publications

Prevalence of Mediterranean Mutation of Glucose 6 Phosphate Dehydrogenase in Children of Malak Din Khel Subtribe of Afridi

Prevalence of Mediterranean Mutation of Glucose 6 Phosphate Dehydrogenase in Children of Malak Din Khel Subtribe of Afridi

Hemolysis After Medication Exposure in Pediatric Patients With G6PD Deficiency

Prevalence of G6PD deficiency and associated haematological parameters in children from Botswana

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