Correlation Between Number of Retrieved Oocytes and Pregnancy Rate After<i>In Vitro</i>Fertilization/IntraCytoplasmic Sperm Infection

Timeva, Tanya; Milachich, Tanya; Антонова, И И; Arabaji, Tanya; Shterev, A; Omar, Hatim A.

doi:10.1100/tsw.2006.145

Cited by 36 publications

(26 citation statements)

References 12 publications

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“…Five retrieved oocytes were associated with an ideal ongoing pregnancy rate (67 %) per embryo transfer in patients undergoing a mild stimulation protocol using GnRH-antagonist [49,50]. On the other hand, a development of less than five follicles in a standard stimulation protocol is usually associated with poor outcome related to the low number transferred embryos and high cancellation rate due to the fertilization failure [51].…”

Section: Discussionmentioning

confidence: 99%

Accumulation of oocytes from a few modified natural cycles to improve IVF results: a pilot study

Greco

Litwicka

Arrivi

et al. 2013

J Assist Reprod Genet

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Purpose To evaluate the role of co-transfer of embryos derived from vitrified oocytes accumulated during the previous modified natural cycles and an embryo developed from the last one as an alternative to repetitive single embryo transfer in a fresh modified natural cycle. Methods Thirty-six patients underwent ICSI procedure with three frozen natural oocytes supplemented by a fresh one obtained from the fourth modified natural cycle. Thirty-one controls received at least three consecutive single embryo transfer in a fresh modified natural cycle. Results In the study group the oocyte retrieval, survival and total fertilization rate were 73.0 %, 78.1 %, and 64.5 %, respectively. Fifty-two embryos were transferred in 29 transfers. In the control group the oocyte retrieval and fertilization rate was 77.4 % and 83.7 %, respectively. Fifty single embryo transfers were performed. Of a total 14 pregnancies obtained in the study group 10 were defined as clinical and 4 as abortions. In the control group a total of 8 single clinical pregnancies and 2 miscarriages were encountered. The overall (20.0 % vs 48.2 %) and the clinical (16.0 % vs 34.4 %) pregnancy rate were significantly higher in the study group having cumulative embryo transfer following the oocyte accumulation. Conclusions These data demonstrate that the co-transfer of embryos derived from vitrified oocytes accumulated during the previous modified natural cycles and an embryo developed from the last fresh modified natural cycle assure an excellent clinical outcome with the overall and clinical pregnancy rate significantly higher compared to the repetitive single embryo transfer in a fresh modified natural cycle.

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Section: Discussionmentioning

confidence: 99%

Accumulation of oocytes from a few modified natural cycles to improve IVF results: a pilot study

Greco

Litwicka

Arrivi

et al. 2013

J Assist Reprod Genet

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show abstract

“…In the case of equal ovarian assessment, other parameters could influence pregnancy rate, for example age [18][19][20][21], which is the most important predictive variable of live birth in IVF. Globally, women who are poor responders have a lower pregnancy rate than normally responding women [19,[22][23][24]. Even in young poor responders IVF results are low but acceptable [25].…”

Section: Introductionmentioning

confidence: 99%

Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study

Marca

Grisendi

Giulini

et al. 2015

J Assist Reprod Genet

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Purpose to compare the baseline characteristics and chance of live birth in the different categories of poor responders identified by the combinations of the Bologna criteria and establish whether these groups comprise a homogenous population. Methods database containing clinical and laboratory information on IVF treatment cycles carried out at the Mother-Infant Department of the University Hospital of Modena between year 2007 and 2011 was analysed. This data was collected prospectively and recorded in the registered database of the fertility centre. Eight hundred and thirty women fulfilled the inclusion/ exclusion criteria of the study and 210 women fulfilled the Bologna criteria definition for poor ovarian response (POR). Five categories of poor responders were identified by different combinations of the Bologna criteria. Results There were no significant differences in female age, AFC, AMH, cycle cancellation rate and number of retrieved oocytes between the five groups. The live birth rate ranged between 5.5 and 7.4 % and was not statistically different in the five different categories of women defined as poor responders according to the Bologna criteria. Conclusion The study demonstrates that the different groups of poor responders based on the Bologna criteria have similar IVF outcomes. This information validates the Bologna criteria definition as women having a uniform poor prognosis and also demonstrates that the Bologna criteria poor responders in the various subgroups represent a homogenous population with similar pre-clinical and clinical outcomes.

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“…This strategy prevents technical drift, thus, efficiency was rapidly reached with satisfactory clinical results. However, hyperstimulation context with the collection of large numbers of oocytes at pick up accounts for our low fertilization rates, equally obtained in both fresh and vitrified/warmed oocytes [14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

“…However, it is of common knowledge that oocyte quality is negatively correlated with the size of oocyte cohort [14][15][16][17]. We chose to split the cohort in the freshly collected part to maintain satisfactory success chances for each couple and to vitrify the rest.…”

Section: Discussionmentioning

confidence: 99%

Oocyte vitrification: A local validation of the method

Boyer¹,

Montjean²,

Tourame³

et al. 2013

OJOG

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Is there a really need to validate oocyte vitrification technique in an ART laboratory before establishing it in daily practice? Validation of micromanipulationbased technique, in this case oocyte vitrification, is essential prior to enlarging its use to routine practice. Oocyte vitrification is a new worldwide used technique and legal recently in France. This micromanipulation needs to be performed by a skilled and experienced embryologist and requires an internal assessment in each ART unit before any wide use. We designed a prospective study, from September 2011 to July 2012, using sibling oocytes from women who recovered more than 12 Metaphase II oocytes. A part of freshly recovered oocytes underwent immediate ICSI while the remaining oocytes were vitrified. 87 couples undergoing ICSI were selected based on number of mature oocytes available on the recovery day after denudation. A part of fresh MII oocytes were microinjected and the others were vitrified using an open system (Cryotop ® ). The major criterion of interest was the number of embryo transferred/ number of Metaphase II ratio for after ICSI on fresh oocytes (42/211) versus vitrified/warmed oocytes (51/204) (p > 0.05). Secondary studied criteria were survival rate (80.5% ± 26.3%), fertilization rate (68.9 ± 33.5) and finally, cumulative pregnancy rate obtained in this study is 40.2%. One of the benefits of such practice is the limitation of embryo freezing. However, the study design delays oocytes warming cycles, due to pregnancies triggered by the transfer of fresh derived oocyte embryos and to the priority to transfer all the frozen embryos before starting oocytes warming. Moreover, no data is available about children' health. Oocyte vitrification represents not only a change in our daily practice to improve cumulative pregnancy rate but also a promising tool to develop egg banking and donation. Clinical Trials Registration number: 209 R02.

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Correlation Between Number of Retrieved Oocytes and Pregnancy Rate AfterIn VitroFertilization/IntraCytoplasmic Sperm Infection

Cited by 36 publications

References 12 publications

Accumulation of oocytes from a few modified natural cycles to improve IVF results: a pilot study

Accumulation of oocytes from a few modified natural cycles to improve IVF results: a pilot study

Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study

Oocyte vitrification: A local validation of the method

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