Background: Hypertension is an important cause of cardiovascular-related morbidity and mortality. This study aimed to evaluate the effect of demographic, biochemical, and lifestyle variables on hypertension in the last five years in Kerman, Iran. Methods: About 2055 adults were randomly selected through single-stage cluster sampling. Demographic characteristics, biochemical variables, tobacco use, opium use, mood, and physical activity were examined. The effect of the studied variables on hypertension was also measured. COPY methods were used to estimate relative risk (RR) and create confidence intervals. All statistical analysis were done in R 4.4.1. Results: Based on the results obtained using the multivariable COPY method for hypertension, the effects of age, education, physical activity, diabetes, obesity, smoking, anxiety, and depression were significant. It was also found that people with a family history of hypertension and a history of diabetes, obesity, and smoking are at higher risk for hypertension. Conclusion: The present study showed that the results of this study can be effective in designing and implementing intervention programs for the control and prevention of hypertension in this area.