Correlation between osteoarthritic changes in the stifle joint in dogs and the results of orthopedic, radiographic, ultrasonographic and arthroscopic examinations

Ramírez-Flores, Gabriel Ignacio; Del-Angel-Caraza, Javier; Hernández, Israel; Hulse, Donald A.; Beale, Brian S.; Victoria-Mora, José M.

doi:10.1007/s11259-017-9680-2

Cited by 23 publications

(35 citation statements)

References 31 publications

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“…Osteoarthritis is a chronic degenerative disease affecting the articular cartilage and subchondral bone; it causes pain and inhibits movement. 1 Approximately 20% of the canine population develops osteoarthritis. 2 Since the discovery in 2001 by Zuk and colleagues 3 that adipose tissue is a major source of mesenchymal stem cells, scientists have been studying the use of adipose-derived stem cells for the treatment of various disorders including osteoarthritis.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Pavarotti

Hivernaud²,

Brincin

et al. 2020

Vet Comp Orthop Traumatol

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Objective The aim of this study was to investigate the safety, feasibility and clinical efficacy of a single intra-articular injection of autologous and purified micro-fragmented adipose tissue for the treatment of osteoarthritis (OA) in dogs. Study Design Twenty-one client-owned dogs with radiographically confirmed OA were recruited into this prospective study. Lameness and discomfort were evaluated by physical examination at day 0 and then 14, 30, 60 and 180 days after injection. Kinetic data and temporospatial parameters were obtained using a pressure-sensing walkway. Peak vertical force, vertical impulse and percentages of body weight distribution were determined. Owner perception data regarding their own dog's physical activity were also collected using the Canine Brief Pain Inventory. Results Radiographic scores for OA from days 0 to 180 were similar, except in two dogs. No major side effects were noted after injection. Lameness and Canine Brief Pain Inventory scores were significantly lower at all time points compared with day 0. Post-injection results demonstrated gradual improvement of kinetic data up to day 180 compared with pre-treatment values: vertical impulse (>2.25%), peak vertical force (>5.32%) and percentages of body weight distribution (>3.6%). In dogs with elbow OA, gait analysis values significantly increased at all time points compared with day 0. Conclusion Regenerative autologous adipose tissue injection therapy is a promising alternative to traditional analgesics treatment in patients with OA, associated with significant reductions in pain and lameness, delayed disease progression and improved quality of life.

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Section: Introductionmentioning

confidence: 99%

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Pavarotti

Hivernaud²,

Brincin

et al. 2020

Vet Comp Orthop Traumatol

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“…CrCL insufficiency leads to stifle instability, which results in cranial subluxation of the tibia relative to the femur during joint loading [3]. Stifle joint instability results in lameness and the development of osteoarthritis [4, 5]. The CrCL consists of 2 functional components: a craniomedial band and a caudolateral band [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Ex vivo preliminary investigation of radiographic quantitative assessment of cranial tibial displacement at varying degrees of canine stifle flexion with or without an intact cranial cruciate ligament

Castaneda¹,

Hudson²,

Beale³

2018

BMC Vet Res

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BackgroundThe presence of cranial tibial subluxation can aid in the detection of joint instability as a result of CrCL injury. Detection of cranial tibial subluxation has been described using the tibial compression test (TCT) and cranial drawer test (CDT); however, diagnosis of CrCL insufficiency by assessing cranial subluxation motion of the tibia is subjective and difficult to quantify accurately. The aim of this study was to investigate a measurement technique to assess the degree of cranial tibial displacement relative to the femoral condyles on mediolateral projection stifle radiographs at varying degrees of stifle flexion (90°, 110°, and 135°) in CrCL intact, partially, and completely transected conditions. Radiographic measurements included: CrCL length and intercondylar distance (ICD), defined as the distance between the tibial mechanical axis (TMA) and the femoral condylar axis (FCA). The influence of CrCL status, stifle flexion angle, and measurement type on measured distance was evaluated. The relationship between CrCL length and ICD measurement was also assessed.ResultsComplete transection of the CrCL resulted in significant cranial tibial displacement. Stifle flexion angle affected ICD, but not CrCL length. Normalized measured CrCL length and ICD were significantly different; however, no differences existed between the change in distance detected by CrCL length and ICD measurements as CrCL transection status changed. Correlation coefficients detected a significant positive correlation between measured CrCL and ICD.ConclusionThe ICD measurement technique was able to quantify tibial displacement at various stifle flexion angles in the intact and completely transected CrCL conditions. The ICD measurement was more affected by stifle flexion angle than was the CrCL length.Electronic supplementary materialThe online version of this article (10.1186/s12917-018-1599-5) contains supplementary material, which is available to authorized users.

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“…8 Correlation of sonographic features of OA (osteophytes, joint effusion and synovial thickening) has been assessed, albeit in the absence of regional cartilage evaluation. 9 Magnetic resonance imaging (MRI) is a newer modality in veterinary medicine being used more commonly to assess musculoskeletal injury in dogs. Magnetic resonance imaging is noninvasive, permits multiplane imaging of the stifle without the use of ionizing radiation and has the spatial and quantitative abilities to evaluate canine articular cartilage.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging T2 Values of Stifle Articular Cartilage in Normal Beagles

Pownder¹,

Hayashi²,

Caserto³

et al. 2018

Vet Comp Orthop Traumatol

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Objectives The purpose of this study was to evaluate regional differences of canine stifle articular cartilage using the quantitative magnetic resonance imaging (MRI) technique of T2 mapping. Methods Fourteen stifle joints from seven juvenile male Beagle dogs with no evidence or prior history of pelvic limb lameness were imaged ex vivo using standard of care fast spin echo MRI and quantitative T2 mapping protocols. Regions of interest were compared between the femoral, patellar and tibial cartilages, as well as between the lateral and medial femorotibial compartments. Limbs were processed for histology with standard stains to confirm normal cartilage. Results The average T2 value of femoral trochlear cartilage (37.5 ± 2.3 ms) was significantly prolonged (p < 0.0001) as compared with the femoral condylar, patellar and tibial condylar cartilages (33.1 ± 1.5 ms, 32.8 ± 2.3 ms, and 28.0 ± 1.7 ms, respectively). When comparing medial and lateral condylar compartments, the lateral femoral condylar cartilage had the longest T2 values (34.8 ± 2.8 ms), as compared with the medial femoral condylar cartilage (30.9 ± 1.9 ms) and lateral tibial cartilage (29.1 ± 2.3 ms), while the medial tibial cartilage had the shortest T2 values (26.7 ± 2.4 ms). Clinical Significance As seen in other species, regional differences in T2 values of the canine stifle joint are identified. Understanding normal regions of anticipated prolongation in different joint compartments is needed when using quantitative imaging in models of canine osteoarthritis.

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Correlation between osteoarthritic changes in the stifle joint in dogs and the results of orthopedic, radiographic, ultrasonographic and arthroscopic examinations

Cited by 23 publications

References 31 publications

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Ex vivo preliminary investigation of radiographic quantitative assessment of cranial tibial displacement at varying degrees of canine stifle flexion with or without an intact cranial cruciate ligament

Magnetic Resonance Imaging T2 Values of Stifle Articular Cartilage in Normal Beagles

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