Correlation between overweightness and the extent of coronary atherosclerosis among the South Caspian population

Abstract

Background: Reported effects of obesity on the extent of angiographic coronary artery disease(CAD) have been inconsistent. The present study aimed to investigate the relationships between the indices of obesity and other anthropometric markers with the extent of CAD. Methods: This study was conducted on 1008 consecutive patients who underwent coronary angiography. Body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were separately calculated for each patient. Extent, severity, and complexity of CAD were determined by the Gensini and SYNTAX scores. Results: According to the results, there was a significant inverse correlation between the SYNTAX score with BMI (r = − 0.110; P < 0.001), WC (r = − 0.074; P = 0.018), and WHtR (r = − 0.089; P = 0.005). Furthermore, a significant inverse correlation was observed between the Gensini score with BMI (r = − 0.090; P = 0.004) and WHtR (r = − 0.065; P = 0.041). However, the results of multivariate linear regression analysis did not show any association between the SYNTAX and Gensini scores with the indices of obesity and overweight. On the other hand, the patients with an unhealthy WC had a higher prevalence of diabetes mellitus (DM) (P = 0.004) and hypertension (HTN) (P < 0.001), compared to the patients with healthy values. Coexistence of HTN and DM was more prevalent in subjects with an unhealthy WC and WHR, compared to that in those with healthy values (P = 0.002 and P = 0.032, respectively). Conclusion: It seems that the anthropometric indices of obesity are not the predictors of the angiographic severity of CAD. However, they are associated with an increased risk of cardiovascular risk factors and higher risk profile.

Evaluation of Tumor Necrosis Factor Alpha, Insulin, glucose, HbA1c% and HOMA-IR as Predictors for Cardiovascular Diseases in Patients with Type 2 Diabetes

“…These findings support 31 they noted that the average BMI of CVD patients was below 25, and they proposed that obesity is a separate risk factor for CVD in both sexes. The results also support, 32 they discovered that a greater risk profile and BMI are both strongly connected with an increased risk of cardiovascular risk factors. 33 It has been found that individuals with a higher BMI have a greater likelihood of being linked to cardiovascular risk factors such as hypertension, hypercholesterolemia, and diabetes mellitus.…”

Association Between a Body Shape Index and Subclinical Carotid Atherosclerosis in Population Free of Cardiovascular and Cerebrovascular Diseases

“…Waist circumference (WC, cm) is regarded as a simple physical measure to assess central obesity, but it does not take into account differences in height and overall body shape. Waist-to-hip ratio (WHR) and waist-toheight ratio (WHtR) have also been associated with increased arterial stiffness, but the relationship is not always significant [8][9][10] . A body shape index (ABSI) and the body roundness index (BRI) are newly developed anthropometric indices.…”

Association of Anthropometric Measurements with Angiographic findings among Diabetic Patients with Coronary Artery Disease

“…This is a cross-sectional study conducted among 78 consecutive diabetic patients who underwent coronary angiography for known or suspected coronary atherosclerosis of both sexes aged between 35 and 65 years with significant angiographic findings of >50% diameter stenosis at the cardiac department of a tertiary care hospital with their prior informed consent. The sample size was calculated at a 5% level of significance and 27.86 standard deviations based on the study by Nabati et al, 10 with a 7% margin of error.…”