Correlation between oxidative stress and hematological profile abnormalities in diabetic nephropathy

Abdel-Moneim, Adel; Mahmoud, Basant; Nabil, Ahmed; Negeem, Zinab

doi:10.1016/j.dsx.2019.06.014

Cited by 12 publications

(11 citation statements)

References 34 publications

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“…As a simple indicator of inflammation, peripheral blood leukocytes comprising neutrophils, monocytes, and lymphocytes have previously been found to be related to the development of CKD in patients with diabetes. [7][8][9][10]15 Our study suggested that of the peripheral blood leucocytes, neutrophil count was the most reliable independent risk factor for CKD, both in the cross-sectional and cohort studies. Neutrophil count and lymphocyte count are the principal components of the WBC count, and increasing WBC in CKD would have been largely due to the increased number of neutrophils.…”

Section: Discussionmentioning

confidence: 64%

Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes

Zhang

Chen

Xiong

et al. 2022

Journal of Diabetes

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Background: This study aims to investigate the potential association of peripheral inflammatory blood cell parameters with the incidence and progression of chronic kidney disease (CKD) in patients with diabetes. Methods: The cross-sectional study included 1192 subjects with diabetes derived from one center. The cohort study included 2060 subjects with diabetes derived from another two centers followed up for 4 years. Logistic regression and Cox proportional hazards models were used to evaluate the association of peripheral inflammatory blood cell with CKD. Results: In the cross-sectional study, neutrophil count performed best as an independent risk factor for CKD (odds ratio 2.556 [95% confidence interval 1.111, 5.879]) even after 1:1 case-control matching for age, gender, history of high blood pressure and duration of diabetes. Spline regression revealed a significant linear association of CKD incidence with continuous neutrophil count in excess of 3.6 Â 10 9 /L. In the cohort study, subjects were grouped based on tertile of neutrophil count and neutrophil-to-lymphocyte ratio. Cox regression analysis results showed that only neutrophil count was independently # Co-first author

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Section: Discussionmentioning

confidence: 64%

Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes

Zhang

Chen

Xiong

et al. 2022

Journal of Diabetes

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“…The etiology and pathogenesis of diabetic nephropathy (DN) are complex and diverse [1]. There are many factors involved, such as infection, autoimmunity, genetics, drugs, diet, and environment [2,3]. The specific pathogenesis is still not fully clear.…”

Section: Introductionmentioning

confidence: 99%

Uncovering the Mechanism of Astragalus membranaceus in the Treatment of Diabetic Nephropathy Based on Network Pharmacology

Guo

Dai

Gao

et al. 2020

Journal of Diabetes Research

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Background. Diabetic nephropathy (DN), characterized by hyperglycemia, hypertension, proteinuria, and edema, is a unique microvascular complication of diabetes. Traditional Chinese medicine (TCM) Astragalus membranaceus (AM) has been widely used for DN in China while the pharmacological mechanisms are still unclear. This work is aimed at undertaking a network pharmacology analysis to reveal the mechanism of the effects of AM in DN. Materials and Methods. In this study, chemical constituents of AM were obtained via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of AM were identified using the Therapeutic Target Database (TTD). DisGeNET and GeneCards databases were used to collect DN-related target genes. DN-AM common target protein interaction network was established by using the STRING database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out to further explore the DN mechanism and therapeutic effect of AM. The network diagrams of the active component-action target and protein-protein interaction (PPI) networks were constructed using Cytoscape software. Results. A total of 16 active ingredients contained and 78 putative identified target genes were screened from AM, of which 42 overlapped with the targets of DN and were considered potential therapeutic targets. The analysis of the network results showed that the AM activity of component quercetin, formononetin, calycosin, 7-O-methylisomucronulatol, and quercetin have a good binding activity with top ten screened targets, such as VEGFA, TNF, IL-6, MAPK, CCL3, NOS3, PTGS2, IL-1β, JUN, and EGFR. GO and KEGG analyses revealed that these targets were associated with inflammatory response, angiogenesis, oxidative stress reaction, rheumatoid arthritis, and other biological process. Conclusions. This study demonstrated the multicomponent, multitarget, and multichannel characteristics of AM, which provided a novel approach for further research of the mechanism of AM in the treatment of DN.

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“…This is an important common mechanism involved in the pathophysiology of several diseases, including obesity and metabolic syndrome, diabetes, vascular diseases, neurodegenerative diseases, and malignancy. [13][14][15][16][17] Importantly, oxidative stress further negatively affects male semen quality and fertility. 18 A negative association with seminal parameters, such as total/progressive motility, sperm concentration, morphology, and vitality, has been repeatedly reported.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of oxidative stress testing in semen for sperm DNA fragmentation assessed by sperm chromatin dispersion test

et al. 2020

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Background:Although standard semen analysis is a cornerstone of male infertility investiation, it has significant limitations. Seminal oxidative stress and DNA damage have shown potential to better predict male fertility potential and provide improved diagnostic and management strategies.Objective: The aim of this study was to investigate whether seminal oxidationreduction potential (ORP), a new parameter to measure oxidative stress directly, can accurately predict the percentage of sperm DNA fragmentation (SDF) and thereby serve as a surrogate marker in the evaluation of male infertility. Materials and methods: ORP was evaluated in 3968 patients using the MiOXSYS system and SDF in 1147 patients using the Halosperm G2 test kit. Both parameters were analyzed in 1068 patients, along with seminal analysis, according to WHO guidelines 2010 (5th edition).Results: SDF correlated positively with seminal ORP normalized for sperm concentration (n = 1068; r = .218; P < .0001) as well as with ORP normalized for the motile sperm concentration (motORP; n = 1068; r = .387; P < .0001). MotORP can significantly (P < .0001) better predict SDF than ORP normalized for the sperm concentration (area under the curve (AUC): 0.719 vs 0.623) (specificity: 71.5%; sensitivity: 61.9%; PPV: 47.1%; NPV: 82.1%). Moreover, motORP can significantly (P < .0001) better predict (AUC: 0.826 vs 0.771) normozoospermia with high sensitivity (82.75%) and specificity (68.5%).Discussion: Unlike other oxidative stress (OS) markers, ORP provides a global vision of the redox balance in semen. Moreover, SDF can also be induced by mechanisms different from OS, which could explain why its predictive power was low. The higher predictive power of motORP reflects the impact of seminal ROS on motility rather than inherent DNA breaks present in immature and aborted apoptotic spermatozoa. Conclusion:The evaluation of motORP seems a more promising parameter than ORP normalized for sperm concentration for the prediction of SDF and normozoospermia.However, even if ORP and SDF are inter-related, they measure independent sperm functions and one test cannot replace the other in the evaluation of sperm function defects. | 611ELBARDISI Et AL.

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Correlation between oxidative stress and hematological profile abnormalities in diabetic nephropathy

Cited by 12 publications

References 34 publications

Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes

Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes

Uncovering the Mechanism of Astragalus membranaceus in the Treatment of Diabetic Nephropathy Based on Network Pharmacology

Predictive value of oxidative stress testing in semen for sperm DNA fragmentation assessed by sperm chromatin dispersion test

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