Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope

Wang, Xianwen; Liu, Xiangwei; Zheng, Lulu; Liu, Yubo; Guan, Zhengyan; Chen, Xiaobin

doi:10.3389/fneur.2023.1104621

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…The association between unexplained syncope and RLS persisted after adjusting for small vessels disease burden [ 36 ]. Interestingly, PFO closure may prevent the recurrence of syncope, and the prevalence of recurrent syncope was much lower in patients who underwent PFO closure than that of the non-closure group (11.0% vs. 35%, p = 0.018) [ 37 ]. Nevertheless, the evidence that percutaneous PFO closure can effectively prevent the recurrence of unexplained syncope is still limited.…”

Section: Pfo and Syncopementioning

confidence: 99%

Prevalence and characteristics of patent foramen ovale in a sample of Egyptian population: a computed tomography study

Shehata,

Nasser,

Mohsen

et al. 2024

Egypt Heart J

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Background The reported prevalence of patent foramen ovale (PFO) in the general population is variable. It ranges between 8.6 and 42% according to the population studied and the imaging technique used. We aim to prospectively assess the prevalence and characteristics of PFO and interatrial septum (IAS) abnormalities as well as the related clinical manifestations in a sample of Egyptian population. Results This study comprised 1000 patients who were referred for CT coronary angiography (CTCA). Mean age was 52.5 ± 10.9 years. The prevalence of PFO among the studied population was 16.3%; closed PFO (grade I) 44.2%, open PFO (grade II) 50.9%, and open PFO with jet (grade III) 4.9%. Anatomical high-risk PFO features—defined as the presence of at least 2 or more of the following (diameter ≥ 2 mm, length ≥ 10 mm, septal aneurysm “ASA”, or redundant septum)—were found in 51.5% of PFOs’ population. Other IAS abnormalities as redundant septum (8.6%), ASA (5.3%), Bachmann’s bundle (4.5%), microaneurysm (2.6%), and atrial septal defect (ASD) (0.4%) were detected. There was a lower rate of coexistence of ASA with PFO (p = 0.031). Syncope was significantly higher in patients with PFO compared to those without PFO (6.7% vs. 1.6%, p = 0.001). Stroke, transient ischaemic attacks (TIA), and dizziness were similar in both groups. TIA, dizziness, and syncope were significantly higher in patients with IAS abnormalities including PFO compared to those without IAS abnormalities. Syncope was also significantly higher in PFO with high-risk anatomical features compared to those with non-high-risk PFO population (p = 0.02). Conclusion The prevalence of PFO in our study was approximately 16.3%, almost half of them showed anatomical high-risk features for stroke. Dizziness, syncope and TIA were significantly higher in patients with IAS abnormalities including PFO.

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Section: Pfo and Syncopementioning

confidence: 99%

Prevalence and characteristics of patent foramen ovale in a sample of Egyptian population: a computed tomography study

Shehata,

Nasser,

Mohsen

et al. 2024

Egypt Heart J

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“…Patent foramen ovale (PFO) is a remnant of fetal foramen ovale with an overall incidence of 27.3% [ 3 ]. PFO is associated with transient ischemia attack (TIA) or stroke, paradoxical embolism, and migraine in adults [ 4 ], and PFO closure may reduce the risk of PFO-associated stroke in patients younger than 60 years with an embolic-appearing stroke [ 5 , 6 ]. Besides, PFO closure also decreases the incidences of platypnea-orthodeoxia, fainting episodes, syncope, and migraine headaches [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The association between patent foramen ovale and unexplained syncope in pediatric patients

Zou,

Wang,

Liu

et al. 2024

Ital J Pediatr

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Background Patent foramen ovale (PFO) is associated with transient ischemia attack (TIA) or stroke, paradoxical embolism, and migraines. PFO closure decreases the recurrent incidence of cerebral ischemic events and reduces the incidence of syncope in adults. However, whether PFO is associated with syncope in pediatric patients has not been investigated. Methods 1001 pediatric patients (aged 4 to 17 years, mean age 10.31 ± 2.61 years, 519 males) who complained of unexplained syncope, palpitation, headache, dizziness and chest pain and were hospitalized in the Syncope Ward, The Second Xiangya Hospital, Central South University between January 2013 and April 2022 were recruited. Children with definite etiology of syncope, neurological, cardiogenic, psychological and other system diseases were excluded. PFO was measured by transthoracic echocardiography and right-heart contrast echocardiography was performed to identify the presence of right-to-left shunting. The demographic data and medical records were retrospectively reviewed and analyzed. Results 276 cases were included in the simple syncope group, 379 cases in the headache/dizziness group, 265 cases in the chest pain group, and 81 cases in the palpitation group. The incidence of PFO between the four groups was insignificant (4.71%, 4.74%, 4.15%, 6.17%, respectively, P = 0.903). Multivariate Logistic regression demonstrated that PFO is not associated with the increased risk of syncope (P = 0.081). Conclusion PFO may not increase the risk of syncope in pediatric patients. Further study may include a large and multicenter sample to investigate the association between PFO and unexplained syncope.

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Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope

Cited by 2 publications

References 40 publications

Prevalence and characteristics of patent foramen ovale in a sample of Egyptian population: a computed tomography study

Prevalence and characteristics of patent foramen ovale in a sample of Egyptian population: a computed tomography study

The association between patent foramen ovale and unexplained syncope in pediatric patients

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