Correlation between Photopic Negative Response of Focal Electroretinograms and Local Loss of Retinal Neurons in Glaucoma

Tamada, Kunifusa; Machida, Shigeki; Oikawa, Taku; Miyamoto, Hiroyuki; Nishimura, Tomoharu; Kurosaka, Daijiro

doi:10.3109/02713680903447926

Cited by 25 publications

(20 citation statements)

References 17 publications

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“…However, within the perimetric patient group, a direct correlation between the two was absent. Consistent with previous studies, the RNFLT was significantly reduced in pre-perimetric and perimetric patients [4,39,40]. Furthermore, the significant correlation between the LN-off and LN-add amplitudes and the RNFLT indicates that LN-off component is a more sensitive indicator for retinal nerve fibre layer integrity than the LN-on component.…”

Section: Correlation Between Lns and Other Functional And Structural supporting

confidence: 90%

“…Recent data have shown that the PhNR is correlated with functional measures of retinal ganglion cells integrity like visual field [5,35] and with structural parameters like retinal nerve fibre layer thickness (RNFLT) in glaucoma patients [4,39,40] and in patients with optic nerve atrophy [37]. Similarly, there is evidence that PERG amplitudes are correlated with visual field defects [41] and the RNFLT in glaucoma patients [42].…”

Section: Introductionmentioning

confidence: 93%

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On- and off-response ERGs elicited by sawtooth stimuli in normal subjects and glaucoma patients

et al. 2012

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The aim of this study is to measure the on- and off-responses and their response asymmetries elicited by sawtooth stimuli in normal subjects and glaucoma patients. Furthermore, the correlation between the ERGs and other functional and structural parameters are investigated. Full-field stimuli were produced using a Ganzfeld bowl with Light Emitting Diodes (LEDs) as light sources. On- and off-response ERGs were recorded from 17 healthy subjects, 12 pre-perimetric and 15 perimetric glaucoma patients using 4-Hz luminance rapid-on and rapid-off sawtooth stimuli (white light; mean luminance 55 cd/m(2)) at 100% contrast. The on- and off-responses were added to study response asymmetries. In addition, flash ERGs were elicited by red stimuli (200 cd/m(2)) on a blue background (10 cd/m(2)). The mean deviations (MD) of the visual field defects were obtained by standard automated perimetry. The retinal nerve fibre layer thickness (RNFLT) was measured with Spectral Domain Optical Coherence Tomography (SOCT). We studied the correlation between ERG response amplitudes, visual field mean deviation (MDs) and RNFLT values. The on-responses showed an initial negative (N-on) followed by a positive (P-on), a late positive (LP-on) and a late negative responses (LN-on). The off-responses showed an initial positive (P-off) a late positive (LP-off) and a late negative response (LN-off). The addition of on- and off-responses revealed an initial positive (P-add) and a late negative response (LN-add). The on-response components (N-on, P-on and LN-on) in the glaucoma patients were relatively similar to those of the control subjects. However, the LP-on was significantly elevated (p = 0.03) in perimetric patients. The LP-off was significantly elevated (p < 0.001), and the amplitude of LN-off was significantly reduced in perimetric patients (p = 0.02). The LN-add amplitude was significantly reduced (p < 0.001) and delayed (p = 0.03) in perimetric patients. The amplitudes of the LN-off and LN-add ERG components were significantly correlated with the PhNR in the flash ERG (LN-off: p = 0.01; LN-add: p < 0.001) and with RNFLT (LN-off: p = 0.006; LN-add: p = 0.001). On- and off-response ERGs and their response asymmetries, elicited by sawtooth stimuli, are altered in the glaucoma patients. The late components are affected. Changes in the late negative components are correlated with structural and other functional changes.

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Section: Correlation Between Lns and Other Functional And Structural supporting

confidence: 90%

Section: Introductionmentioning

confidence: 93%

On- and off-response ERGs elicited by sawtooth stimuli in normal subjects and glaucoma patients

et al. 2012

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“…The PhNR amplitude was measured from the baseline to the negative trough at 70 msec according to the findings in earlier studies [18,19]. The amplitudes of OP1, OP2, and OP3 were measured and summed, and are designated as ΣOPs as reported [18,20].…”

Section: Focal Macular Erg (Fmerg) Recordingsmentioning

confidence: 99%

Structures affecting recovery of macular function in patients with age-related macular degeneration after intravitreal ranibizumab

Nishimura

Machida

Hashizume

et al. 2014

Graefes Arch Clin Exp Ophthalmol

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“…22 To reduce variability among individuals, the amplitude of the PhNR was normalized by that of the b-wave and this ratio was designated as the PhNR/b-wave amplitude ratio. [23][24][25][26] The ERG recordings were made 12 months after MH surgery for the MH patients.…”

Section: Recording Focal Macular Electroretinogramsmentioning

confidence: 99%

“…[22][23][24][25][26] We have found that the amplitude of the focal PhNR was correlated with a decrease in retinal sensitivity 23 and retinal neurons represented by rim area of the optic disc and nerve fiber layer thickness. 26 Thus, the focal PhNR amplitude is related to the severity of the OAG.…”

Section: Introductionmentioning

confidence: 99%

Differences in Functional Loss Associated with Ganglion Cell Complex Thinning between Patients with Glaucoma and Postoperative Macular Hole

Machida

Tamada

Ohzeki

et al. 2014

Current Eye Research

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Correlation between Photopic Negative Response of Focal Electroretinograms and Local Loss of Retinal Neurons in Glaucoma

Abstract: These results strongly suggest that the anatomical losses of retinal neurons in local areas of the retina or optic nerve head are a cause of the reduction in the amplitude of the focal photopic negative response in open angle glaucoma.

Cited by 25 publications

References 17 publications

On- and off-response ERGs elicited by sawtooth stimuli in normal subjects and glaucoma patients

On- and off-response ERGs elicited by sawtooth stimuli in normal subjects and glaucoma patients

Structures affecting recovery of macular function in patients with age-related macular degeneration after intravitreal ranibizumab

Differences in Functional Loss Associated with Ganglion Cell Complex Thinning between Patients with Glaucoma and Postoperative Macular Hole

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