2012
DOI: 10.1007/s11596-012-0017-7
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Correlation between physical status of human papilloma virus and cervical carcinogenesis

Abstract: The prevalence of human papilloma virus (HPV)-16 in patients with cervical cancer, the physical status of HPV-16 in patients with cervical lesions, and the role of HPV-16 integration in cervical carcinogenesis were investigated. HPV genotyping was performed by using PCR approach with the primer GP5+/GP6+ and type-specific primer on biopsy specimens taken operatively from 198 women. Multiple PCR was done to detect physical status of HPV-16 in a series of cervical liquid-based cytology samples and biopsy specime… Show more

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Cited by 10 publications
(5 citation statements)
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“…Persistent high-risk HPV infection may promote the development of SIL. Low-grade and high-grade SIL seem to be part of a continuum of elevated E6 and E7 expression (24) in addition to an elevated ratio of integrated-to-episomal viral DNA (5,26). The expression of oncogenic E6 and E7 in the basal epithelium is under stringent control, being expressed at low levels in SIL.…”
Section: Data Abstraction and Categorizationmentioning
confidence: 99%
See 2 more Smart Citations
“…Persistent high-risk HPV infection may promote the development of SIL. Low-grade and high-grade SIL seem to be part of a continuum of elevated E6 and E7 expression (24) in addition to an elevated ratio of integrated-to-episomal viral DNA (5,26). The expression of oncogenic E6 and E7 in the basal epithelium is under stringent control, being expressed at low levels in SIL.…”
Section: Data Abstraction and Categorizationmentioning
confidence: 99%
“…Accumulation of chromosomal instability due to elevated and continued E6 and E7 expression causes the basal cells at this stage to lose transcriptional control of E6 and E7 (26). This results in further chromosomal instability, and more integration events associated with concomitant loss of the repressor protein E2 (5,26). This will provide ideal conditions for unhampered E6-induced degradation of p53.…”
Section: Data Abstraction and Categorizationmentioning
confidence: 99%
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“…HR-HPV infection is etiologically associated with cervical carcinomas, anogenital and a subset of head and neck squamous cell carcinomas (HNSCCs). Integration of HR-HPV genomes into the host is an important hit, although not a requisite for epithelial carcinogenesis [ 47 , 48 ]. This is common in HSIL and cervical SCC compared with normal or LSIL tissues [ 49 ].…”
Section: Hpv In Cervical Cancermentioning
confidence: 99%
“…Additionally, E2 gene is also believed to take a part in cervical cancer since in about 35% of HPV induced cervical cancers full length viral genomes are expressed. [89,90] The regulation of gene expression is changed when the viral DNA integrates with the cell chromosomes. This integration leads to a continuous expression of E6 and E7 proteins causing accumulation of mutations of the cellular DNA and promoting malignancies.…”
Section: Lower Genital Tract Neoplasias: Cervical Vaginal and Vulvarmentioning
confidence: 99%