Correlation between physicochemical properties and non-covalent interactions involving l-arginine/l-histidine and semicarbazide hydrochloride at temperatures from 293.15 to 318.15 K

Insight into Interactions of l-Arginine/l-Histidine with Drug Betaine Hydrochloride in Aqueous Medium at Different Temperatures by using Physicochemical Methods

“…As part of a comprehensive study of physicochemical properties of drugs, present study embrace measurement of the volumetric, acoustic and viscometric properties of l-arginine and l-histidine in aqueous and aqueous-betaine hydrochloride. In earlier contributions [9][10][11][12][13], we studied the properties of mixture of amino acids and drug solutions. In this paper, an attempt has been made to have an admissible information on the behavior of amino acids in aqueous solutions of betaine hydrochloride by measuring densities, ρ , ultrasonic speed, u and viscosities, η of solutions of l-arginine and l-histidine in aqueous and aqueousbetaine hydrochloride (1% and 2% betaine hydrochloride in water, w/w) solvents at temperatures from 293.15 to 318.15 K and at atmospheric pressure.…”

Thermophysical Studies on Molecular Interactions of Semicarbazide Hydrochloride/Domiphen Bromide in Aqueous Deep Eutectic Solvent Media at Various Temperatures

“…Various thermodynamic parameters of binary and ternary solutions are calculated to analyze the drug molecular interactions. Analyzing the characteristics of solutions of drugs offers better insights into the solute–co-solute and solute–solvent associations. , These physicochemical parameters define the ADME (absorption, distribution, metabolism, extraction) conduct of drugs . Therefore, we have conducted volumetric, viscometric, and acoustic studies of semicarbazide hydrochloride and domiphen bromide in the presence of a deep eutectic solvent (DES), maline (DES composed of choline chloride and malonic acid in the mol ratio of 1:2).…”