Correlation Between Phytoestrogens Intake With Telomere Length in Minangkabau Premenopausal Women

Desmawati, Desmawati; Sulastri, Delmi; Lestari, Yuniar; Jamsari, Jamsari

doi:10.22159/ajpcr.2018.v11i11.29509

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Additionally, estrogen has antioxidant properties that may protect telomeres against increased oxidative stress and damage telomeres 46 . Estrogen directly activates the telomerase promoter through phosphoinositol-3-kinase/Akt and nitric oxide pathways and indirectly affects DNA repair through the P53 pathway 47 . In contrast, testosterone in males lacks antioxidant properties that may increase the deleterious effects of oxidative stress on telomeres.…”

Section: Discussionmentioning

confidence: 99%

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Body mass index and shortened telomere length in middle-aged female and male RUNNING HEAD: Middle-aged and shortened telomere length

Al-Thuwaini

2022

Baghdad Sci.J

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Obesity is a risk factor associated with age-related disorders that accelerate aging, and it increases the risk of metabolic diseases. Therefore, this study was conducted to investigate the association of leukocyte telomere length (LTL) with the presence of higher body weight in middle-aged females and males. The study subjects comprised 160 (80 control and 80 higher body mass index BMI groups) with ranging ages of 30-50 years included and stratified for BMI. The physio-biochemical analysis was measured using enzymatic determination. Mean telomere length was determined by using the southern blotting technique. The association analysis revealed a significant variance (P < 0.01) in biochemical parameters between higher BMI groups and control including waist, lipid profile, and the level of estradiol, testosterone, folliclestimulating hormone, and luteinizing hormone. Mean telomere length was shorter in middle-aged males compared to the females of higher BMI groups and control groups for both age groups. LTL was shorter in the overweight and obese patients compared with the control group, and these differences in LTL obese group were shorter compared to the overweight group. In conclusion, shorter telomere length was observed in middle-aged males associated with higher body weight and lipid abnormalities. Lipid/lipoprotein abnormalities can be used as a predictor for the shortened telomere length and the reduction in adiposity indices can improvement the telomere length in both overweight and obese subjects.

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Section: Discussionmentioning

confidence: 99%

“…The telomeric probe was revealed by the digoxigenin luminescent procedure after being exposed to X-ray film. As the telomeres shorten with age, all samples were taken at the same age group (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50) to determine the telomere length.…”

Section: Dna Extraction and Telomere Lengthmentioning

confidence: 99%

Body mass index and shortened telomere length in middle-aged female and male RUNNING HEAD: Middle-aged and shortened telomere length

Al-Thuwaini

2022

Baghdad Sci.J

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Tofu and Tempeh, the Mostly Sources of Phytoestrogens in Minangkabau Premenopausal Women Ethnicity

Desmawati

Fasrini

Lestari

et al. 2021

IOP Conf. Ser.: Earth Environ. Sci.

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Phytoestrogens are estrogen-like substances that come from outside the body, especially from plants. Phytoestrogens can bind to estrogen receptors, causing estrogen-like effects. Consumption of phytoestrogens in premenopausal women may help estrogen function due to decreased production. This study aims to determine the source of phytoestrogens consumed by Minangkabau ethnic premenopausal women. This study used a cross-sectional design conducted on 127 premenopausal women in Padang City, West Sumatra. Data on the intake of source food ingredients were taken through guided interviews using a semiquantitative-food frequent questionnaire (SQ_FFQ). According to the United States Department of Agriculture (USDA) guidelines, the amount of phytoestrogen intake is calculated manually. The study results show five groups of food ingredients containing phytoestrogens most consumed by premenopausal women of Minangkabau ethnicity. It were tofu (97.62 grams/day); fish (70.7 grams/day); oranges (35.36 grams/day); potatoes (34 grams/day), and tempeh (23.3 grams/day). Meanwhile, most food sources of phytoestrogens are tofu (containing 19.26 mg of phytoestrogens / day), tempeh (15.6 mg / day), pure soybean milk (0.04 mg / day) and fish (0.1 mg / day). It can be concluded that tofu and tempeh are food sources of phytoestrogens that are mostly consumed by premenopausal women of Minangkabau ethnicity in Padang City.

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Correlation Between Phytoestrogens Intake With Telomere Length in Minangkabau Premenopausal Women

Cited by 2 publications

References 25 publications

Body mass index and shortened telomere length in middle-aged female and male RUNNING HEAD: Middle-aged and shortened telomere length

Body mass index and shortened telomere length in middle-aged female and male RUNNING HEAD: Middle-aged and shortened telomere length

Tofu and Tempeh, the Mostly Sources of Phytoestrogens in Minangkabau Premenopausal Women Ethnicity

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